STRINGSTRING
LOC100534415 LOC100534415 bmp2 bmp2 LOC100711913 LOC100711913 LOC100695903 LOC100695903 bmp4 bmp4 LOC100694803 LOC100694803 LOC100710281 LOC100710281 LOC100534578 LOC100534578 THSD4 THSD4 id2 id2 bambi bambi LOC100711374 LOC100711374 I3JB83_ORENI I3JB83_ORENI bmp8a bmp8a rbl1 rbl1 LOC100690458 LOC100690458 LOC100705578 LOC100705578 LOC100694986 LOC100694986 I3JEN4_ORENI I3JEN4_ORENI LOC100694653 LOC100694653 myc myc LOC100704141 LOC100704141 smad7 smad7 rbx1 rbx1 acvr1 acvr1 acvr1c acvr1c Rock1 Rock1 smad1 smad1 chrd chrd ltbp1 ltbp1 LOC100698527 LOC100698527 thbs1b thbs1b I3K2B3_ORENI I3K2B3_ORENI ACVR2A ACVR2A smad9 smad9 LOC100705713 LOC100705713 LOC100698095 LOC100698095 LOC100702473 LOC100702473 rgmb rgmb tfdp1 tfdp1 fst fst bmp6 bmp6 LOC100710008 LOC100710008 LOC100710325 LOC100710325 nodal nodal LOC106098551 LOC106098551 LOC100709989 LOC100709989 skp1 skp1 ppp2ca ppp2ca LOC100691773 LOC100691773 Zfyve9 Zfyve9 LOC100694608 LOC100694608 LOC100710477 LOC100710477 LOC100699905 LOC100699905 LOC100694220 LOC100694220 LOC100693128 LOC100693128 TGFBR2 TGFBR2 tgfb3 tgfb3 GREM1 GREM1 LOC100695597 LOC100695597 LOC100700968 LOC100700968 LOC100706019 LOC100706019 Crebbp Crebbp LOC102075500 LOC102075500 I3IZA5_ORENI I3IZA5_ORENI LOC100706678 LOC100706678 ENSONIP00000033751 ENSONIP00000033751 LOC100707378 LOC100707378 pitx2 pitx2 tgfb2 tgfb2 LOC100703326 LOC100703326 smad6 smad6 LOC100695177 LOC100695177 LOC100706145 LOC100706145 e2f4 e2f4 LOC102081105 LOC102081105 LOC100697746 LOC100697746 cul1 cul1 LOC100699754 LOC100699754 LOC100701625 LOC100701625 LOC100693017 LOC100693017 LOC100709201 LOC100709201 NBL1 NBL1 rgma rgma Bmpr2 Bmpr2 neo1 neo1 LOC100707445 LOC100707445 LOC100704395 LOC100704395 gdf6 gdf6 LOC100708381 LOC100708381 I3K925_ORENI I3K925_ORENI LOC100710422 LOC100710422 LOC100705918 LOC100705918 I3JF61_ORENI I3JF61_ORENI LOC100698785 LOC100698785 LOC100709560 LOC100709560 thbs1 thbs1 LOC100691078 LOC100691078 LOC100705058 LOC100705058 sp1 sp1 LOC100705094 LOC100705094 LOC100711095 LOC100711095 dcn dcn grem2 grem2 LOC100693620 LOC100693620 id1 id1 SMURF2 SMURF2 LOC109204099 LOC109204099 ACVR1B ACVR1B SMAD3 SMAD3 LOC100698988 LOC100698988 LOC100698871 LOC100698871 LOC100700725 LOC100700725 LOC100697722 LOC100697722 gdf5 gdf5 LOC100691573 LOC100691573 mapk1 mapk1 bmp5 bmp5 amh amh LOC100694444 LOC100694444
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100534415Hepcidin-like isoform X1. (85 aa)
bmp2Bone morphogenetic protein 2b. (418 aa)
LOC100711913Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
LOC100695903Left-right determination factor. (418 aa)
bmp4Bone morphogenetic protein 4. (403 aa)
LOC100694803Ras homolog family member Cb. (193 aa)
LOC100710281Serine/threonine-protein phosphatase. (309 aa)
LOC100534578Tumor necrosis factor b (TNF superfamily, member 2). (247 aa)
THSD4Thrombospondin type 1 domain containing 4. (971 aa)
id2Inhibitor of DNA binding 2a. (136 aa)
bambiBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (256 aa)
LOC100711374Nodal-related 1. (404 aa)
I3JB83_ORENIRGM domain family, member D. (463 aa)
bmp8aBone morphogenetic protein 8a. (452 aa)
rbl1Retinoblastoma-like 1 (p107). (1064 aa)
LOC100690458Transforming growth factor beta; Belongs to the TGF-beta family. (419 aa)
LOC100705578E2F_TDP domain-containing protein. (79 aa)
LOC100694986Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1210 aa)
I3JEN4_ORENISerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (520 aa)
LOC100694653Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (520 aa)
LOC100704141Inhibitor of DNA binding 4. (141 aa)
smad7Mothers against decapentaplegic homolog. (376 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
acvr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1280 aa)
acvr1cReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
Rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1353 aa)
smad1Mothers against decapentaplegic homolog. (468 aa)
chrdChordin; Belongs to the chordin family. (949 aa)
ltbp1Latent transforming growth factor beta binding protein 1. (1496 aa)
LOC100698527Growth differentiation factor 7. (390 aa)
thbs1bThrombospondin 1a. (1172 aa)
I3K2B3_ORENIReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (505 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (558 aa)
smad9Mothers against decapentaplegic homolog. (468 aa)
LOC100705713Serine/threonine-protein phosphatase. (311 aa)
LOC100698095Mothers against decapentaplegic homolog. (501 aa)
LOC100702473Southpaw. (413 aa)
rgmbRepulsive guidance molecule BMP co-receptor b. (476 aa)
tfdp1Transcription factor. (413 aa)
fstFollistatin a. (339 aa)
bmp6Bone morphogenetic protein 6. (428 aa)
LOC100710008Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
LOC100710325Mothers against decapentaplegic homolog. (467 aa)
nodalNodal-related 2. (386 aa)
LOC106098551Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (614 aa)
LOC100709989CREB binding protein a. (2384 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
LOC100691773Fibromodulin b. (346 aa)
Zfyve9Zinc finger, FYVE domain containing 9a. (1201 aa)
LOC100694608Anti-dorsalizing morphogenic protein. (386 aa)
LOC100710477Ras homolog gene family, member Ab. (193 aa)
LOC100699905Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
LOC100694220Fibromodulin a. (349 aa)
LOC100693128TGF_BETA_2 domain-containing protein. (387 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (538 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (405 aa)
GREM1Gremlin. (182 aa)
LOC100695597Uncharacterized protein. (283 aa)
LOC100700968Noggin; Belongs to the noggin family. (211 aa)
LOC100706019Gremlin 1a, DAN family BMP antagonist. (236 aa)
CrebbpCREB binding protein b. (2433 aa)
LOC102075500Hepcidin. (83 aa)
I3IZA5_ORENIMothers against decapentaplegic homolog. (220 aa)
LOC100706678Inhibitor of DNA binding 3. (122 aa)
ENSONIP00000033751Hepcidin-like isoform X1. (89 aa)
LOC100707378Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (127 aa)
pitx2Homeobox protein. (313 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (422 aa)
LOC100703326Homeobox protein TGIF2. (578 aa)
smad6Mothers against decapentaplegic homolog. (488 aa)
LOC100695177Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
LOC100706145Mothers against decapentaplegic homolog. (481 aa)
e2f4E2F transcription factor 4. (407 aa)
LOC102081105TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (169 aa)
LOC100697746TNF_2 domain-containing protein. (239 aa)
cul1Cullin 1b; Belongs to the cullin family. (1038 aa)
LOC100699754Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (516 aa)
LOC100701625Bone morphogenetic protein 7a. (425 aa)
LOC100693017Growth differentiation factor 6a. (442 aa)
LOC100709201TGF_BETA_2 domain-containing protein. (391 aa)
NBL1NBL1, DAN family BMP antagonist. (187 aa)
rgmaRepulsive guidance molecule BMP co-receptor a. (453 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1033 aa)
neo1Neogenin 1b. (1466 aa)
LOC100707445Uncharacterized protein. (193 aa)
LOC100704395TGF_BETA_2 domain-containing protein. (390 aa)
gdf6Growth differentiation factor 6b. (436 aa)
LOC100708381Mothers against decapentaplegic homolog. (526 aa)
I3K925_ORENISerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
LOC100710422Inhibin subunit beta C. (374 aa)
LOC100705918TGFB-induced factor homeobox 1. (330 aa)
I3JF61_ORENIBone morphogenetic protein 16. (580 aa)
LOC100698785Uncharacterized protein. (193 aa)
LOC100709560Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (530 aa)
thbs1Thrombospondin 1b. (1186 aa)
LOC100691078E3 ubiquitin-protein ligase. (844 aa)
LOC100705058Inhibin subunit beta B. (404 aa)
sp1Sp1 transcription factor. (726 aa)
LOC100705094Mothers against decapentaplegic homolog. (765 aa)
LOC100711095Zgc:113307. (375 aa)
dcnDecorin; May affect the rate of fibrils formation. (359 aa)
grem2Gremlin 2, DAN family BMP antagonist a. (195 aa)
LOC100693620Myelocytomatosis oncogene homolog. (357 aa)
id1Inhibitor of DNA binding 1, HLH protein. (130 aa)
SMURF2E3 ubiquitin-protein ligase. (747 aa)
LOC109204099Hepcidin-like. (130 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (506 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC100698988E1A binding protein p300 a. (2777 aa)
LOC100698871Hepcidin-2. (90 aa)
LOC100700725E1A binding protein p300 b. (2799 aa)
LOC100697722Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (398 aa)
gdf5Growth differentiation factor 5. (479 aa)
LOC100691573Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (566 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
bmp5Bone morphogenetic protein 5. (458 aa)
amhAnti-mullerian hormone. (540 aa)
LOC100694444Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (472 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.