(54 nodes) Cytosolic DNA-sensing pathway network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100694194	Receptor-interacting serine-threonine kinase 3. (506 aa)
	LOC100691708	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (305 aa)
	LOC102077017	Uncharacterized protein. (220 aa)
	LOC100693633	PYD and CARD domain containing. (201 aa)
	I3J6Y0_ORENI	Uncharacterized protein; Belongs to the peptidase C14A family. (383 aa)
	LOC100708116	Uncharacterized protein; Belongs to the peptidase C14A family. (399 aa)
	I3JNN1_ORENI	Uncharacterized protein; Belongs to the peptidase C14A family. (276 aa)
	polr3c	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (547 aa)
	Polr3f	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
	LOC100697816	Zgc:171971. (389 aa)
	LOC109203135	Uncharacterized protein. (189 aa)
	LOC100691290	Uncharacterized protein. (189 aa)
	LOC100707066	Interleukin-1. (244 aa)
	LOC100692869	Component of inhibitor of nuclear factor kappa B kinase complex. (757 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (678 aa)
	LOC109202764	SCY domain-containing protein. (89 aa)
	LOC100693282	Interleukin-1. (255 aa)
	mavs	CARD_2 domain-containing protein. (552 aa)
	polr3e	Polymerase (RNA) III (DNA directed) polypeptide E. (689 aa)
	polr3a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1402 aa)
	LOC100698148	Protein kinase domain-containing protein. (777 aa)
	ikbke	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (318 aa)
	LOC100702954	Interferon regulatory factor 3. (466 aa)
	rela	V-rel avian reticuloendotheliosis viral oncogene homolog A. (616 aa)
	adar	Adenosine deaminase RNA specific. (1363 aa)
	ENSONIP00000032073	Interferon a3-like. (210 aa)
	Polr1d	DNA-directed RNA polymerases I and III subunit RPAC2 isoform X2. (140 aa)
	POLR2E	RNA polymerase II subunit E. (249 aa)
	tbk1	TANK-binding kinase 1. (746 aa)
	LOC109204785	Cyclic GMP-AMP synthase. (627 aa)
	sting1	Stimulator of interferon genes protein. (403 aa)
	polr3h	Polymerase (RNA) III (DNA directed) polypeptide H. (218 aa)
	ENSONIP00000047097	Uncharacterized protein LOC109196975. (181 aa)
	ENSONIP00000049557	C-C motif chemokine 4-like. (98 aa)
	ENSONIP00000050933	C-X-C motif chemokine 10. (87 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
	ENSONIP00000057334	C-X-C motif chemokine 10. (106 aa)
	polr2h	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (621 aa)
	irf7	Interferon regulatory factor 7. (461 aa)
	polr3b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1132 aa)
	LOC102083274	Interferon alpha. (206 aa)
	polr2f	Polymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
	LOC109194378	C-X-C motif chemokine 10 isoform X1. (135 aa)
	Polr1c	RNA polymerase I and III subunit C. (360 aa)
	ENSONIP00000073042	Interferon a3-like. (149 aa)
	ENSONIP00000073123	C-C motif chemokine 4. (95 aa)
	card16	Uncharacterized protein. (96 aa)
	polr3k	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
	ENSONIP00000078528	C-C motif chemokine 17. (95 aa)
	polr2l	DNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
	ENSONIP00000079430	C-X-C motif chemokine 10. (90 aa)
	polr2k	DNA-directed RNA polymerases I, II, and III subunit RPABC4. (58 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000032073	LOC100702954	ENSONIP00000032073	ENSONIP00000025281	Interferon a3-like.	Interferon regulatory factor 3.	0.907
ENSONIP00000032073	irf7	ENSONIP00000032073	ENSONIP00000060688	Interferon a3-like.	Interferon regulatory factor 7.	0.908
ENSONIP00000032073	rela	ENSONIP00000032073	ENSONIP00000028680	Interferon a3-like.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.900
ENSONIP00000047097	LOC100693282	ENSONIP00000047097	ENSONIP00000014133	Uncharacterized protein LOC109196975.	Interleukin-1.	0.936
ENSONIP00000047097	LOC100693633	ENSONIP00000047097	ENSONIP00000002766	Uncharacterized protein LOC109196975.	PYD and CARD domain containing.	0.961
ENSONIP00000047097	LOC100707066	ENSONIP00000047097	ENSONIP00000010489	Uncharacterized protein LOC109196975.	Interleukin-1.	0.976
ENSONIP00000049557	ENSONIP00000073123	ENSONIP00000049557	ENSONIP00000073123	C-C motif chemokine 4-like.	C-C motif chemokine 4.	0.901
ENSONIP00000049557	ENSONIP00000078528	ENSONIP00000049557	ENSONIP00000078528	C-C motif chemokine 4-like.	C-C motif chemokine 17.	0.900
ENSONIP00000049557	LOC109202764	ENSONIP00000049557	ENSONIP00000013683	C-C motif chemokine 4-like.	SCY domain-containing protein.	0.900
ENSONIP00000050933	ENSONIP00000057334	ENSONIP00000050933	ENSONIP00000057334	C-X-C motif chemokine 10.	C-X-C motif chemokine 10.	0.900
ENSONIP00000050933	ENSONIP00000079430	ENSONIP00000050933	ENSONIP00000079430	C-X-C motif chemokine 10.	C-X-C motif chemokine 10.	0.900
ENSONIP00000050933	LOC109194378	ENSONIP00000050933	ENSONIP00000064962	C-X-C motif chemokine 10.	C-X-C motif chemokine 10 isoform X1.	0.900
ENSONIP00000057334	ENSONIP00000050933	ENSONIP00000057334	ENSONIP00000050933	C-X-C motif chemokine 10.	C-X-C motif chemokine 10.	0.900
ENSONIP00000057334	ENSONIP00000079430	ENSONIP00000057334	ENSONIP00000079430	C-X-C motif chemokine 10.	C-X-C motif chemokine 10.	0.900
ENSONIP00000057334	LOC109194378	ENSONIP00000057334	ENSONIP00000064962	C-X-C motif chemokine 10.	C-X-C motif chemokine 10 isoform X1.	0.900
ENSONIP00000073042	LOC100702954	ENSONIP00000073042	ENSONIP00000025281	Interferon a3-like.	Interferon regulatory factor 3.	0.925
ENSONIP00000073042	irf7	ENSONIP00000073042	ENSONIP00000060688	Interferon a3-like.	Interferon regulatory factor 7.	0.916
ENSONIP00000073042	rela	ENSONIP00000073042	ENSONIP00000028680	Interferon a3-like.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.900
ENSONIP00000073123	ENSONIP00000049557	ENSONIP00000073123	ENSONIP00000049557	C-C motif chemokine 4.	C-C motif chemokine 4-like.	0.901
ENSONIP00000073123	ENSONIP00000078528	ENSONIP00000073123	ENSONIP00000078528	C-C motif chemokine 4.	C-C motif chemokine 17.	0.900