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| | mcm9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1169 aa) |
| | ENSHBUP00000000679 | MutS_I domain-containing protein. (166 aa) |
| | fan1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1106 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1710 aa) |
| | ENSHBUP00000001804 | RFC1 domain-containing protein. (135 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (899 aa) |
| | rfc1 | BRCT domain-containing protein. (471 aa) |
| | rmi2 | RecQ mediated genome instability 2. (146 aa) |
| | brca1 | Uncharacterized protein. (1388 aa) |
| | ENSHBUP00000004241 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (147 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (336 aa) |
| | brip1 | BRCA1 interacting protein C-terminal helicase 1. (1221 aa) |
| | ENSHBUP00000005048 | TAN domain-containing protein. (177 aa) |
| | ENSHBUP00000005062 | Uncharacterized protein. (143 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | cdc6 | Cell division cycle 6 homolog (S. cerevisiae). (429 aa) |
| | tdrd3 | Tudor domain containing 3. (780 aa) |
| | fancm | Uncharacterized protein. (2114 aa) |
| | prim2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (513 aa) |
| | lig1 | DNA ligase. (1012 aa) |
| | ankrd12 | Ankyrin repeat domain 12. (1951 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (444 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2980 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (532 aa) |
| | gins1 | GINS complex subunit 1 (Psf1 homolog). (212 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (498 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa) |
| | primpol | Primase and polymerase (DNA-directed). (521 aa) |
| | LOC102297270 | SCY domain-containing protein. (125 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa) |
| | ENSHBUP00000008246 | Uncharacterized protein. (117 aa) |
| | ENSHBUP00000008317 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1192 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (679 aa) |
| | slf1 | SMC5-SMC6 complex localization factor 1. (885 aa) |
| | orc5 | Origin recognition complex, subunit 5. (450 aa) |
| | ENSHBUP00000009123 | Uncharacterized protein. (264 aa) |
| | ENSHBUP00000009143 | AAA_23 domain-containing protein. (92 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (481 aa) |
| | mlh1 | MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (758 aa) |
| | rhno1 | Si:ch73-352p4.5. (295 aa) |
| | mcmbp | Minichromosome maintenance complex binding protein. (632 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (811 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (828 aa) |
| | pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa) |
| | ENSHBUP00000010473 | BRCT domain-containing protein. (179 aa) |
| | dscc1 | DNA replication and sister chromatid cohesion 1. (390 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa) |
| | LOC102298027 | DBF4 zinc finger. (433 aa) |
| | bivm | Basic, immunoglobulin-like variable motif containing. (496 aa) |
| | cdc45 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (568 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (356 aa) |
| | LRR1 | Leucine rich repeat protein 1. (421 aa) |
| | gen1 | Uncharacterized protein. (887 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3139 aa) |
| | LOC102312405 | ATPase family AAA domain containing 5a. (1808 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1538 aa) |
| | LOC102311559 | WD_REPEATS_REGION domain-containing protein. (318 aa) |
| | blm | BLM RecQ like helicase. (1405 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa) |
| | mlh3 | MutL homolog 3 (E. coli). (1142 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (678 aa) |
| | pold1 | DNA polymerase. (1129 aa) |
| | cdca7 | Cell division cycle associated 7a. (401 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (635 aa) |
| | chek2 | Checkpoint kinase 2. (521 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (464 aa) |
| | gins3 | GINS complex subunit 3. (211 aa) |
| | pms2 | PMS1 homolog 2, mismatch repair system component. (861 aa) |
| | orc3 | Origin recognition complex, subunit 3. (720 aa) |
| | mcph1 | Microcephalin 1. (771 aa) |
| | stn1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (365 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (390 aa) |
| | CLSPN | Claspin. (1353 aa) |
| | LOC102305750 | MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). (911 aa) |
| | brca2 | BRCA2 DNA repair associated. (3303 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (357 aa) |
| | ten1 | TEN1 subunit of CST complex. (130 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | rfwd3 | Ring finger and WD repeat domain 3. (708 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | LOC102292166 | DBF4-type domain-containing protein. (867 aa) |
| | timeless | Timeless circadian clock. (1249 aa) |
| | nbn | Nibrin. (779 aa) |
| | LOC102308989 | ANK_REP_REGION domain-containing protein. (698 aa) |
| | LOC102291787 | Zgc:110269. (388 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (740 aa) |
| | cdc7 | Cell division cycle 7 homolog (S. cerevisiae). (611 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (860 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2016 aa) |
| | rpa2 | Replication protein A2. (293 aa) |
| | xrcc2 | X-ray repair cross complementing 2. (324 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa) |
| | ENSHBUP00000027756 | Uncharacterized protein. (561 aa) |
| | ENSHBUP00000027773 | Uncharacterized protein. (302 aa) |
| | tp73 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (644 aa) |
| | prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | wdhd1 | WD repeat and HMG-box DNA binding protein 1. (686 aa) |
| | chtf8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (136 aa) |
| | atrip | Uncharacterized protein. (789 aa) |
| | rad51d | RAD51 paralog D. (333 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (886 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | exo1 | Exonuclease 1. (737 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | zranb3 | Zinc finger, RAN-binding domain containing 3. (1156 aa) |
| | msh5 | MutS homolog 5. (816 aa) |
| | rbbp8 | Uncharacterized protein. (673 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (175 aa) |
| | fbh1 | F-box DNA helicase 1. (1076 aa) |
| | mcm10 | Minichromosome maintenance 10 replication initiation factor. (867 aa) |
| | mcm8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (844 aa) |
| | piezo1 | Piezo-type mechanosensitive ion channel component. (2306 aa) |
| | cdt1 | Chromatin licensing and DNA replication factor 1. (607 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa) |
| | dna2 | DNA replication helicase/nuclease 2. (1401 aa) |
| | rad1 | RAD1 homolog (S. pombe). (309 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (695 aa) |
| | recql4 | RecQ helicase-like 4. (1577 aa) |
| | chtf18 | AAA domain-containing protein. (922 aa) |
| | msh4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (908 aa) |
| | cdca7l | Cell division cycle associated 7b. (402 aa) |
| | LOC102306769 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (817 aa) |
| | orc1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (898 aa) |
| | LOC102297614 | RAD51 paralog C. (359 aa) |
| | ENSHBUP00000033958 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (229 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (692 aa) |
| | mcm5 | DNA helicase; Belongs to the MCM family. (767 aa) |
| | pola1 | DNA polymerase. (1482 aa) |
| | ENSHBUP00000034351 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (138 aa) |
| | LOC102303847 | Uncharacterized protein. (251 aa) |
| | pms1 | PMS1 homolog 1, mismatch repair system component. (897 aa) |
| | orc2 | Origin recognition complex, subunit 2. (604 aa) |
| | msh2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1001 aa) |
