(22 nodes) PCNA-Dependent Long Patch Base Excision Repair network (Haplochromis burtoni)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	ENSHBUP00000001804	RFC1 domain-containing protein. (135 aa)
	rfc1	BRCT domain-containing protein. (471 aa)
	ENSHBUP00000004241	Polymerase (DNA directed), epsilon 3 (p17 subunit). (147 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	lig1	DNA ligase. (1012 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (444 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (532 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (481 aa)
	dscc1	DNA replication and sister chromatid cohesion 1. (390 aa)
	rfc2	Replication factor C (activator 1) 2. (356 aa)
	LOC102312405	ATPase family AAA domain containing 5a. (1808 aa)
	pold1	DNA polymerase. (1129 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	LOC102291787	Zgc:110269. (388 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2016 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	chtf8	CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (136 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	chtf18	AAA domain-containing protein. (922 aa)
	rad17	RAD17 checkpoint clamp loader component. (692 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000001804	ENSHBUP00000004241	ENSHBUP00000001804	ENSHBUP00000004241	RFC1 domain-containing protein.	Polymerase (DNA directed), epsilon 3 (p17 subunit).	0.833
ENSHBUP00000001804	LOC102291787	ENSHBUP00000001804	ENSHBUP00000025039	RFC1 domain-containing protein.	Zgc:110269.	0.899
ENSHBUP00000001804	LOC102312405	ENSHBUP00000001804	ENSHBUP00000012971	RFC1 domain-containing protein.	ATPase family AAA domain containing 5a.	0.547
ENSHBUP00000001804	chtf18	ENSHBUP00000001804	ENSHBUP00000032900	RFC1 domain-containing protein.	AAA domain-containing protein.	0.899
ENSHBUP00000001804	chtf8	ENSHBUP00000001804	ENSHBUP00000028928	RFC1 domain-containing protein.	CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae).	0.775
ENSHBUP00000001804	dscc1	ENSHBUP00000001804	ENSHBUP00000010650	RFC1 domain-containing protein.	DNA replication and sister chromatid cohesion 1.	0.834
ENSHBUP00000001804	fen1	ENSHBUP00000001804	ENSHBUP00000028542	RFC1 domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.899
ENSHBUP00000001804	lig1	ENSHBUP00000001804	ENSHBUP00000006664	RFC1 domain-containing protein.	DNA ligase.	0.886
ENSHBUP00000001804	pcna	ENSHBUP00000001804	ENSHBUP00000029821	RFC1 domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.984
ENSHBUP00000001804	pold1	ENSHBUP00000001804	ENSHBUP00000017205	RFC1 domain-containing protein.	DNA polymerase.	0.857
ENSHBUP00000001804	pold2	ENSHBUP00000001804	ENSHBUP00000009226	RFC1 domain-containing protein.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.751
ENSHBUP00000001804	pold3	ENSHBUP00000001804	ENSHBUP00000007064	RFC1 domain-containing protein.	Polymerase (DNA-directed), delta 3, accessory subunit.	0.574
ENSHBUP00000001804	pole	ENSHBUP00000001804	ENSHBUP00000025661	RFC1 domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.885
ENSHBUP00000001804	pole2	ENSHBUP00000001804	ENSHBUP00000007426	RFC1 domain-containing protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.836
ENSHBUP00000001804	pole4	ENSHBUP00000001804	ENSHBUP00000008082	RFC1 domain-containing protein.	Polymerase (DNA-directed), epsilon 4, accessory subunit.	0.739
ENSHBUP00000001804	rad17	ENSHBUP00000001804	ENSHBUP00000034015	RFC1 domain-containing protein.	RAD17 checkpoint clamp loader component.	0.943
ENSHBUP00000001804	rfc1	ENSHBUP00000001804	ENSHBUP00000001848	RFC1 domain-containing protein.	BRCT domain-containing protein.	0.894
ENSHBUP00000001804	rfc2	ENSHBUP00000001804	ENSHBUP00000012409	RFC1 domain-containing protein.	Replication factor C (activator 1) 2.	0.992
ENSHBUP00000001804	rfc3	ENSHBUP00000001804	ENSHBUP00000005084	RFC1 domain-containing protein.	Replication factor C (activator 1) 3.	0.994
ENSHBUP00000001804	rfc4	ENSHBUP00000001804	ENSHBUP00000022363	RFC1 domain-containing protein.	Replication factor C (activator 1) 4.	0.992