(21 nodes) Clathrin coat of coated pit, and ENTH domain network (Haplochromis burtoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	epn3	Epsin 3a. (599 aa)
	eps15l1	Epidermal growth factor receptor pathway substrate 15-like 1a. (968 aa)
	gak	Cyclin G associated kinase. (1317 aa)
	LOC102297694	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1637 aa)
	LOC102299474	DUF1681 domain-containing protein. (252 aa)
	ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (358 aa)
	LOC102302032	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (916 aa)
	LOC102297644	Intersectin 2b. (1585 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
	ENSHBUP00000019300	Uncharacterized protein. (499 aa)
	LOC102313950	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (866 aa)
	epn2	Epsin 2. (576 aa)
	LOC102308746	FCH domain only 1. (838 aa)
	ap1b1	AP complex subunit beta. (792 aa)
	cltb	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (212 aa)
	ENSHBUP00000028858	Epidermal growth factor receptor pathway substrate 15 like 1. (543 aa)
	clta	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (232 aa)
	hip1	Huntingtin interacting protein 1. (972 aa)
	cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1686 aa)
	eps15	Epidermal growth factor receptor pathway substrate 15. (1093 aa)
	LOC102303243	Epsin 3b. (597 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000019300	ENSHBUP00000028858	ENSHBUP00000019300	ENSHBUP00000028858	Uncharacterized protein.	Epidermal growth factor receptor pathway substrate 15 like 1.	0.958
ENSHBUP00000019300	LOC102297644	ENSHBUP00000019300	ENSHBUP00000016814	Uncharacterized protein.	Intersectin 2b.	0.992
ENSHBUP00000019300	LOC102297694	ENSHBUP00000019300	ENSHBUP00000011690	Uncharacterized protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.852
ENSHBUP00000019300	LOC102299474	ENSHBUP00000019300	ENSHBUP00000012454	Uncharacterized protein.	DUF1681 domain-containing protein.	0.903
ENSHBUP00000019300	LOC102302032	ENSHBUP00000019300	ENSHBUP00000016716	Uncharacterized protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.996
ENSHBUP00000019300	LOC102303243	ENSHBUP00000019300	ENSHBUP00000034508	Uncharacterized protein.	Epsin 3b.	0.806
ENSHBUP00000019300	LOC102308746	ENSHBUP00000019300	ENSHBUP00000024159	Uncharacterized protein.	FCH domain only 1.	0.906
ENSHBUP00000019300	LOC102313950	ENSHBUP00000019300	ENSHBUP00000019474	Uncharacterized protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.857
ENSHBUP00000019300	ap1b1	ENSHBUP00000019300	ENSHBUP00000024332	Uncharacterized protein.	AP complex subunit beta.	0.966
ENSHBUP00000019300	ap2m1	ENSHBUP00000019300	ENSHBUP00000013490	Uncharacterized protein.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.999
ENSHBUP00000019300	ap2s1	ENSHBUP00000019300	ENSHBUP00000017129	Uncharacterized protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.998
ENSHBUP00000019300	clta	ENSHBUP00000019300	ENSHBUP00000028996	Uncharacterized protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.994
ENSHBUP00000019300	cltb	ENSHBUP00000019300	ENSHBUP00000027473	Uncharacterized protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.994
ENSHBUP00000019300	cltc	ENSHBUP00000019300	ENSHBUP00000031853	Uncharacterized protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.852
ENSHBUP00000019300	epn2	ENSHBUP00000019300	ENSHBUP00000020260	Uncharacterized protein.	Epsin 2.	0.806
ENSHBUP00000019300	epn3	ENSHBUP00000019300	ENSHBUP00000003328	Uncharacterized protein.	Epsin 3a.	0.806
ENSHBUP00000019300	eps15	ENSHBUP00000019300	ENSHBUP00000033592	Uncharacterized protein.	Epidermal growth factor receptor pathway substrate 15.	0.958
ENSHBUP00000019300	eps15l1	ENSHBUP00000019300	ENSHBUP00000006080	Uncharacterized protein.	Epidermal growth factor receptor pathway substrate 15-like 1a.	0.958
ENSHBUP00000019300	gak	ENSHBUP00000019300	ENSHBUP00000009382	Uncharacterized protein.	Cyclin G associated kinase.	0.691
ENSHBUP00000028858	ENSHBUP00000019300	ENSHBUP00000028858	ENSHBUP00000019300	Epidermal growth factor receptor pathway substrate 15 like 1.	Uncharacterized protein.	0.958