(129 nodes) Mixed, incl. Valine, leucine and isoleucine degradation, and Short-chain dehydrogenase/reductase SDR network (Haplochromis burtoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	etfdh	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (622 aa)
	slc27a4	Solute carrier family 27 member 4. (643 aa)
	ivd	Isovaleryl-CoA dehydrogenase. (493 aa)
	ACLY	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1120 aa)
	dhrs12	Dehydrogenase/reductase (SDR family) member 12. (318 aa)
	hsd17b4	Hydroxysteroid (17-beta) dehydrogenase 4. (737 aa)
	LOC102301504	Malate synthase-like. (603 aa)
	acox1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (557 aa)
	ENSHBUP00000001823	Acyl-CoA_ox_N domain-containing protein. (148 aa)
	FADS6	Fatty acid desaturase 6. (372 aa)
	slc27a1	Solute carrier family 27 member 1a. (648 aa)
	ENSHBUP00000002863	Uncharacterized protein. (77 aa)
	acadl	Acyl-CoA dehydrogenase long chain. (442 aa)
	fdxr	NADPH:adrenodoxin oxidoreductase, mitochondrial. (494 aa)
	LOC102304728	Zgc:92275. (452 aa)
	cs	Citrate synthase; Belongs to the citrate synthase family. (469 aa)
	LOC102292090	Uncharacterized protein. (102 aa)
	LOC106633642	DDE_Tnp_1_7 domain-containing protein. (734 aa)
	auh	AU RNA binding protein/enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (328 aa)
	fdx2	Ferredoxin 2. (196 aa)
	ENSHBUP00000005942	Uncharacterized protein. (356 aa)
	acat1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
	acacb	Acetyl-CoA carboxylase beta. (2378 aa)
	acads	Acyl-CoA dehydrogenase short chain. (405 aa)
	LOC102308388	Uncharacterized protein. (112 aa)
	LOC102289343	Ubiquitin associated protein 2b. (1183 aa)
	smim24	Uncharacterized protein. (133 aa)
	ACSS1	Acyl-CoA synthetase short chain family member 1. (587 aa)
	aldh5a1	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (514 aa)
	stpg2	Sperm-tail PG-rich repeat containing 2. (577 aa)
	mecr	Mitochondrial trans-2-enoyl-CoA reductase. (381 aa)
	sugct	Succinyl-CoA:glutarate-CoA transferase. (358 aa)
	LOC102308366	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (468 aa)
	acadm	Acyl-CoA dehydrogenase medium chain. (347 aa)
	LOC102311864	Hydroxysteroid (17-beta) dehydrogenase 14. (148 aa)
	ENSHBUP00000009135	Uncharacterized protein. (178 aa)
	etfb	Electron transfer flavoprotein subunit beta. (254 aa)
	hadhb	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (473 aa)
	ENSHBUP00000009549	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a. (758 aa)
	aldh2	Aldehyde dehydrogenase 2 family member, tandem duplicate 2; Belongs to the aldehyde dehydrogenase family. (547 aa)
	mccc2	Methylcrotonoyl-CoA carboxylase 2 (beta). (564 aa)
	LOC102291640	Zgc:101858. (265 aa)
	acss3	Acyl-CoA synthetase short chain family member 3. (694 aa)
	aasdhppt	Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (299 aa)
	LOC102308435	Acetyl-coenzyme A synthetase. (681 aa)
	ECHDC1	Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (327 aa)
	LOC102309952	Acyl-CoA synthetase short chain family member 2. (634 aa)
	LOC102301037	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (253 aa)
	LOC102301344	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa)
	acat2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (444 aa)
	stoml1	Stomatin (EPB72)-like 1. (405 aa)
	acox3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (692 aa)
	etfa	Electron transfer flavoprotein subunit alpha. (343 aa)
	LOC102312848	Si:dkey-61p9.11. (2101 aa)
	LOC102310052	Solute carrier family 27 member 1. (646 aa)
	LOC102303757	Si:ch211-198n5.11. (576 aa)
	ENSHBUP00000015698	Zgc:154061. (114 aa)
	oxsm	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (465 aa)
	echdc2	Enoyl CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (332 aa)
	abhd10	Transgelin 3b. (290 aa)
	cryz	Crystallin, zeta (quinone reductase). (328 aa)
	acadsb	Acyl-CoA dehydrogenase short/branched chain. (433 aa)
	aldh6a1	Aldehyde dehydrogenase 6 family member A1. (544 aa)
	ENSHBUP00000017758	Uncharacterized protein. (173 aa)
	pecr	Peroxisomal trans-2-enoyl-CoA reductase. (281 aa)
	LOC102310039	Si:dkey-174n20.1. (308 aa)
	LOC102292157	Dehydrogenase/reductase (SDR family) member 4. (303 aa)
	hibch	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (382 aa)
	dhrsx	Dehydrogenase/reductase (SDR family) X-linked; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (347 aa)
	LOC102309791	Zgc:101569; Belongs to the enoyl-CoA hydratase/isomerase family. (315 aa)
	LOC102291096	Solute carrier family 34 member 2b. (642 aa)
	LOC102302169	Retinol dehydrogenase 14b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (323 aa)
	dip2a	Disco-interacting protein 2 homolog A. (1631 aa)
	LOC102299200	Uncharacterized protein. (126 aa)
	ehhadh	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (719 aa)
	cryl1	Crystallin, lambda 1. (311 aa)
	acad8	Acyl-CoA dehydrogenase family, member 8. (429 aa)
	oxct1	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (524 aa)
	LOC102311568	Solute carrier family 34 member 2a. (642 aa)
	mccc1	Methylcrotonoyl-CoA carboxylase 1 (alpha). (715 aa)
	LOC102308251	Serine hydrolase like. (332 aa)
	amacr	Alpha-methylacyl-CoA racemase. (369 aa)
	dhrs7c	Dehydrogenase/reductase (SDR family) member 7Cb. (313 aa)
	LOC102304988	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
	LOC102304290	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
	LOC102292132	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (516 aa)
	ENSHBUP00000025214	Uncharacterized protein. (138 aa)
	LOC102307439	Uncharacterized protein. (167 aa)
	LOC102295565	Acetyl-coenzyme A synthetase. (673 aa)
	LOC102299216	Uncharacterized protein. (636 aa)
	decr1	2,4-dienoyl CoA reductase 1, mitochondrial. (333 aa)
	LOC102308870	Zgc:113054. (551 aa)
	aacs	Acetoacetyl-CoA synthetase. (676 aa)
	eci1	Enoyl-CoA delta isomerase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (302 aa)
	LOC102313844	Uncharacterized protein. (107 aa)
	acaa2	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
	vat1l	Vesicle amine transport 1-like. (413 aa)
	pcca	Propionyl-CoA carboxylase subunit alpha. (587 aa)
	hsdl1	Hydroxysteroid dehydrogenase like 1. (325 aa)
	cbr4	Carbonyl reductase 4. (238 aa)
	pccb	Propionyl-CoA carboxylase subunit beta. (560 aa)
	LOC102313178	Carrier domain-containing protein. (2079 aa)
	acad11	Acyl-CoA dehydrogenase family, member 11. (768 aa)
	palb2	PALB2_WD40 domain-containing protein. (1356 aa)
	metap1d	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (339 aa)
	aasdh	Aminoadipate-semialdehyde dehydrogenase. (1132 aa)
	hadh	Uncharacterized protein. (309 aa)
	FDX1	Ferredoxin 1. (162 aa)
	LOC102308308	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (180 aa)
	hibadha	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (329 aa)
	olah	Oleoyl-ACP hydrolase. (262 aa)
	hadha	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
	pc	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1155 aa)
	LOC102291007	Uncharacterized protein. (387 aa)
	LOC102294806	Aldedh domain-containing protein. (546 aa)
	LOC102304699	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (329 aa)
	agxt2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (516 aa)
	LOC102309512	Dehydrogenase/reductase (SDR family) member 13a, tandem duplicate 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
	LOC102289633	Uncharacterized protein. (243 aa)
	LOC102292688	Zgc:85777. (435 aa)
	abat	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
	GCDH	Glutaryl-CoA dehydrogenase b. (440 aa)
	acaca	Acetyl-CoA carboxylase alpha. (2325 aa)
	ubap2	Ubiquitin associated protein 2a. (1257 aa)
	LOC102306172	Glutaryl-CoA dehydrogenase a. (440 aa)
	LOC102297405	Flj13639. (328 aa)
	echs1	Enoyl CoA hydratase, short chain, 1, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (357 aa)
	fasn	Coiled-coil domain containing 57. (2175 aa)
	LOC102306237	Dehydrogenase/reductase (SDR family) member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (336 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	ACSS1	ENSHBUP00000000683	ENSHBUP00000007264	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Acyl-CoA synthetase short chain family member 1.	0.626
ACLY	ECHDC1	ENSHBUP00000000683	ENSHBUP00000010675	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family.	0.532
ACLY	ENSHBUP00000009549	ENSHBUP00000000683	ENSHBUP00000009549	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	0.532
ACLY	FADS6	ENSHBUP00000000683	ENSHBUP00000002042	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Fatty acid desaturase 6.	0.632
ACLY	LOC102292090	ENSHBUP00000000683	ENSHBUP00000004425	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Uncharacterized protein.	0.624
ACLY	LOC102292132	ENSHBUP00000000683	ENSHBUP00000025200	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.897
ACLY	LOC102295565	ENSHBUP00000000683	ENSHBUP00000026005	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Acetyl-coenzyme A synthetase.	0.626
ACLY	LOC102299200	ENSHBUP00000000683	ENSHBUP00000022489	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Uncharacterized protein.	0.704
ACLY	LOC102301504	ENSHBUP00000000683	ENSHBUP00000001674	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Malate synthase-like.	0.944
ACLY	LOC102303757	ENSHBUP00000000683	ENSHBUP00000015027	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Si:ch211-198n5.11.	0.744
ACLY	LOC102304290	ENSHBUP00000000683	ENSHBUP00000025017	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.691
ACLY	LOC102304988	ENSHBUP00000000683	ENSHBUP00000025015	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.691
ACLY	LOC102308251	ENSHBUP00000000683	ENSHBUP00000023975	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Serine hydrolase like.	0.432
ACLY	LOC102308366	ENSHBUP00000000683	ENSHBUP00000007871	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.691
ACLY	LOC102308388	ENSHBUP00000000683	ENSHBUP00000006706	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Uncharacterized protein.	0.624
ACLY	LOC102308435	ENSHBUP00000000683	ENSHBUP00000010460	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Acetyl-coenzyme A synthetase.	0.626
ACLY	LOC102309791	ENSHBUP00000000683	ENSHBUP00000021080	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Zgc:101569; Belongs to the enoyl-CoA hydratase/isomerase family.	0.532
ACLY	LOC102309952	ENSHBUP00000000683	ENSHBUP00000011702	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Acyl-CoA synthetase short chain family member 2.	0.626
ACLY	LOC102310052	ENSHBUP00000000683	ENSHBUP00000013813	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Solute carrier family 27 member 1.	0.610
ACLY	LOC102312848	ENSHBUP00000000683	ENSHBUP00000013497	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Si:dkey-61p9.11.	0.904