STRINGSTRING
LOC102296557 LOC102296557 ENSHBUP00000005111 ENSHBUP00000005111 fgf23 fgf23 fgfr2 fgfr2 fgf3 fgf3 fgf4 fgf4 LOC102291075 LOC102291075 LOC102310436 LOC102310436 fgf5 fgf5 LOC102291452 LOC102291452 LOC102304610 LOC102304610
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102296557Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
ENSHBUP00000005111Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (255 aa)
fgfr2Fibroblast growth factor receptor. (835 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
LOC102291075Fibroblast growth factor receptor. (709 aa)
LOC102310436Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
LOC102291452Fibroblast growth factor receptor. (818 aa)
LOC102304610Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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