STRINGSTRING
wrap53 wrap53 nsmce2 nsmce2 dkc1 dkc1 lto1 lto1 rad51d rad51d nop10 nop10 LOC102311321 LOC102311321 terf2 terf2 LOC102297614 LOC102297614 dclre1b dclre1b mcrs1 mcrs1 xrcc1 xrcc1 mre11 mre11 tert tert recql4 recql4 slx4 slx4 ino80e ino80e rpa1 rpa1 rtel1 rtel1 gar1 gar1 uchl5 uchl5 fbxo4 fbxo4 dclre1a dclre1a telo2 telo2 xrcc3 xrcc3 LOC102290288 LOC102290288 ENSHBUP00000005048 ENSHBUP00000005048 ENSHBUP00000005062 ENSHBUP00000005062 LOC102309297 LOC102309297 zbtb48 zbtb48 rif1 rif1 ENSHBUP00000005892 ENSHBUP00000005892 pif1 pif1 znf827 znf827 terf2ip terf2ip smc6 smc6 nhp2 nhp2 ENSHBUP00000009123 ENSHBUP00000009123 ENSHBUP00000009143 ENSHBUP00000009143 SLX1 SLX1 ptges3 ptges3 LOC102311156 LOC102311156 parp3 parp3 atr atr blm blm ercc4 ercc4 LOC102299901 LOC102299901 LOC102313340 LOC102313340 ENSHBUP00000016535 ENSHBUP00000016535 prkdc prkdc LOC102291534 LOC102291534 ino80d ino80d ino80 ino80 smc5 smc5 LOC102296596 LOC102296596 xrcc6 xrcc6 tprkb tprkb LOC102307579 LOC102307579 stn1 stn1 brca2 brca2 ercc1 ercc1 xrcc5 xrcc5 rad50 rad50 hus1 hus1 RPA1 RPA1 ENSHBUP00000023677 ENSHBUP00000023677 nfrkb nfrkb nbn nbn tfpt tfpt rad51 rad51
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wrap53WD repeat containing, antisense to TP53. (544 aa)
nsmce2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (500 aa)
lto1LTO1 maturation factor of ABCE1. (141 aa)
rad51dRAD51 paralog D. (333 aa)
nop10NOP10 ribonucleoprotein homolog (yeast). (64 aa)
LOC102311321HTH myb-type domain-containing protein. (740 aa)
terf2HTH myb-type domain-containing protein. (561 aa)
LOC102297614RAD51 paralog C. (359 aa)
dclre1bDNA cross-link repair 1B. (586 aa)
mcrs1Microspherule protein 1. (466 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (627 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (695 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1084 aa)
recql4RecQ helicase-like 4. (1577 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1628 aa)
ino80eINO80 complex subunit E. (236 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1137 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (195 aa)
uchl5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
fbxo4F-box protein 4. (396 aa)
dclre1aDNA cross-link repair 1A (PSO2 homolog, S. cerevisiae). (931 aa)
telo2TEL2, telomere maintenance 2, homolog (S. cerevisiae). (806 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (336 aa)
LOC102290288Uncharacterized protein. (237 aa)
ENSHBUP00000005048TAN domain-containing protein. (177 aa)
ENSHBUP00000005062Uncharacterized protein. (143 aa)
LOC102309297DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (623 aa)
zbtb48Zinc finger and BTB domain containing 48. (712 aa)
rif1Replication timing regulatory factor 1. (2354 aa)
ENSHBUP00000005892TROVE domain-containing protein. (927 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (632 aa)
znf827Zinc finger protein 827. (1527 aa)
terf2ipUncharacterized protein. (685 aa)
smc6Si:dkey-119f1.1. (1088 aa)
nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (154 aa)
ENSHBUP00000009123Uncharacterized protein. (264 aa)
ENSHBUP00000009143AAA_23 domain-containing protein. (92 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (256 aa)
ptges3Prostaglandin E synthase 3b (cytosolic). (159 aa)
LOC102311156Structural maintenance of chromosomes 6. (1089 aa)
parp3Poly [ADP-ribose] polymerase. (559 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3139 aa)
blmBLM RecQ like helicase. (1405 aa)
ercc4Excision repair cross-complementation group 4. (899 aa)
LOC102299901PIN2 (TERF1) interacting telomerase inhibitor 1. (156 aa)
LOC102313340Cyclin E2; Belongs to the cyclin family. (391 aa)
ENSHBUP00000016535Uncharacterized protein. (544 aa)
prkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3889 aa)
LOC102291534TERF1 (TRF1)-interacting nuclear factor 2. (579 aa)
ino80dINO80 complex subunit Da. (1007 aa)
ino80INO80 complex ATPase subunit. (1497 aa)
smc5SMC_N domain-containing protein. (1078 aa)
LOC102296596Protein artemis-like. (585 aa)
xrcc6X-ray repair complementing defective repair in Chinese hamster cells 6. (566 aa)
tprkbTp53rk binding protein; Belongs to the CGI121/TPRKB family. (175 aa)
LOC102307579Prostaglandin E synthase 3a (cytosolic). (159 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (365 aa)
brca2BRCA2 DNA repair associated. (3303 aa)
ercc1Excision repair cross-complementation group 1. (352 aa)
xrcc5X-ray repair complementing defective repair in Chinese hamster cells 5. (739 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
ENSHBUP00000023677Protection of telomeres 1 homolog. (528 aa)
nfrkbNuclear factor related to kappaB binding protein. (1274 aa)
nbnNibrin. (779 aa)
tfptTCF3 (E2A) fusion partner. (199 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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