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tbl3 tbl3 utp11 utp11 mrto4 mrto4 RRP36 RRP36 mrpl44 mrpl44 lsm6 lsm6 wdr18 wdr18 gtpbp4 gtpbp4 ENSHBUP00000025319 ENSHBUP00000025319 ENSHBUP00000025310 ENSHBUP00000025310 exosc8 exosc8 mettl5 mettl5 tsr3 tsr3 mrpl1 mrpl1 rps25 rps25 nop9 nop9 utp3 utp3 rpl35 rpl35 bysl bysl nob1 nob1 bud23 bud23 urb1 urb1 LOC102310173 LOC102310173 ENSHBUP00000014764 ENSHBUP00000014764 utp25 utp25 pih1d1 pih1d1 rrp8 rrp8 wdr74 wdr74 ddx21 ddx21 utp6 utp6 nop14 nop14 imp3 imp3 pih1d2 pih1d2 eri2 eri2 brix1 brix1 nvl nvl pwp1 pwp1 mettl16 mettl16 mrm3 mrm3 rrnad1 rrnad1 tsr1 tsr1 fcf1 fcf1 rexo4 rexo4 c1d c1d tfb2m tfb2m ENSHBUP00000033230 ENSHBUP00000033230 pdcd11 pdcd11 exosc10 exosc10 lyar lyar tsr2 tsr2 abt1 abt1 exosc3 exosc3 trmt2b trmt2b wdr12 wdr12 wbp11 wbp11 ftsj3 ftsj3 exosc2 exosc2 ybey ybey LOC102297662 LOC102297662 nop10 nop10 fam207a fam207a ebna1bp2 ebna1bp2 mphosph10 mphosph10 nop53 nop53 ZNHIT6 ZNHIT6 rpusd1 rpusd1 rpusd2 rpusd2 prkdc prkdc ENSHBUP00000016877 ENSHBUP00000016877 rpp30 rpp30 tfb1m tfb1m ngdn ngdn mrps11 mrps11 rpl7 rpl7 UTP14C UTP14C rpl7l1 rpl7l1 kri1 kri1 rrp7a rrp7a rpf2 rpf2 pop4 pop4 ddx47 ddx47 znhit3 znhit3 bms1 bms1 ddx54 ddx54 wdr46 wdr46 wdr75 wdr75 ENSHBUP00000020789 ENSHBUP00000020789 mterf4 mterf4 rrp12 rrp12 gar1 gar1 LOC102298283 LOC102298283 gnl3 gnl3 rsl1d1 rsl1d1 exosc9 exosc9 rrp9 rrp9 esf1 esf1 helq helq ercc2 ercc2 naf1 naf1 nsun3 nsun3 mrm2 mrm2 riok3 riok3 fdxacb1 fdxacb1 nat10 nat10 LOC102300525 LOC102300525 pin4 pin4 wdr3 wdr3 mrm1 mrm1 LOC102313199 LOC102313199 LOC102304338 LOC102304338 ENSHBUP00000004302 ENSHBUP00000004302 zcchc4 zcchc4 mak16 mak16 mtrex mtrex exosc4 exosc4 nol9 nol9 nsun5 nsun5 mphosph6 mphosph6 ddx51 ddx51 nsun4 nsun4 eri1 eri1 pes1 pes1 ddx27 ddx27 gemin4 gemin4 pa2g4 pa2g4 utp23 utp23 srfbp1 srfbp1 npm3 npm3 ddx18 ddx18 rcl1 rcl1 ddx49 ddx49 rpp40 rpp40 exosc7 exosc7 eif6 eif6 nol6 nol6 nhp2 nhp2 utp20 utp20 wdr36 wdr36 LOC102296826 LOC102296826 riok2 riok2 nsa2 nsa2 rpp38 rpp38 exosc6 exosc6 fbl fbl rrp15 rrp15 trmt61b trmt61b wdr43 wdr43 pop5 pop5 dimt1 dimt1 ddx10 ddx10 ENSHBUP00000010988 ENSHBUP00000010988 trmt112 trmt112 utp4 utp4 bop1 bop1 rpf1 rpf1 dhx37 dhx37 imp4 imp4 nol8 nol8 emg1 emg1 nop2 nop2 ddx56 ddx56 dcaf13 dcaf13 tex10 tex10 ddx52 ddx52 drosha drosha rbm34 rbm34 nol11 nol11 mettl15 mettl15 nol10 nol10 pelp1 pelp1 ENSHBUP00000029220 ENSHBUP00000029220 znhit2 znhit2 utp15 utp15 dkc1 dkc1 krr1 krr1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tbl3Transducin (beta)-like 3. (927 aa)
utp11U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (254 aa)
mrto4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (239 aa)
RRP36Ribosomal RNA processing 36. (322 aa)
mrpl44Mitochondrial ribosomal protein L44. (331 aa)
lsm6LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa)
wdr18WD repeat domain 18. (468 aa)
gtpbp4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
ENSHBUP00000025319U3snoRNP10 domain-containing protein. (334 aa)
ENSHBUP00000025310BP28CT domain-containing protein. (335 aa)
exosc8Exosome component 8. (272 aa)
mettl5Methyltransferase like 5. (208 aa)
tsr3Probable ribosome biogenesis protein; Probable pre-rRNA processing protein involved in ribosome biogenesis. (296 aa)
mrpl1Mitochondrial ribosomal protein L1. (319 aa)
rps2540S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (123 aa)
nop9Uncharacterized protein. (613 aa)
utp3UTP3 small subunit processome component. (472 aa)
rpl35Ribosomal protein L35. (123 aa)
byslBystin-like. (435 aa)
nob1RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (407 aa)
bud23BUD23 rRNA methyltransferase and ribosome maturation factor. (282 aa)
urb1URB1 ribosome biogenesis homolog. (2255 aa)
LOC102310173Ribonuclease P and MRP subunit p25, b. (235 aa)
ENSHBUP00000014764UTP18 small subunit processome component. (101 aa)
utp25UTP25 small subunit processor component. (762 aa)
pih1d1PIH1 domain containing 1. (324 aa)
rrp8Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (537 aa)
wdr74WD repeat domain 74. (375 aa)
ddx21DEAD (Asp-Glu-Ala-Asp) box helicase 21. (796 aa)
utp6UTP6 small subunit processome component. (595 aa)
nop14NOP14 nucleolar protein homolog (yeast). (862 aa)
imp3IMP U3 small nucleolar ribonucleoprotein 3. (183 aa)
pih1d2PIH1 domain containing 2. (318 aa)
eri2ERI1 exoribonuclease family member 2. (730 aa)
brix1Brix domain containing 2. (342 aa)
nvlNuclear VCP like. (859 aa)
pwp1PWP1 homolog, endonuclein. (487 aa)
mettl16U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (556 aa)
mrm3Mitochondrial rRNA methyltransferase 3a. (455 aa)
rrnad1Ribosomal RNA adenine dimethylase domain containing 1. (575 aa)
tsr1TSR1 ribosome maturation factor. (831 aa)
fcf1FCF1 rRNA-processing protein. (187 aa)
rexo4REX4 homolog, 3'-5' exonuclease. (427 aa)
c1dC1D nuclear receptor corepressor. (167 aa)
tfb2mrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (453 aa)
ENSHBUP00000033230Reverse transcriptase domain-containing protein. (532 aa)
pdcd11Programmed cell death 11. (1806 aa)
exosc10Exosome component 10. (862 aa)
lyarLy1 antibody reactive homolog (mouse). (344 aa)
tsr2TSR2 ribosome maturation factor. (219 aa)
abt1Activator of basal transcription 1. (405 aa)
exosc3Exosome component 3. (244 aa)
trmt2btRNA methyltransferase 2 homolog B; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (491 aa)
wdr12Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (421 aa)
wbp11Uncharacterized protein. (731 aa)
ftsj3pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (855 aa)
exosc2Exosome component 2. (293 aa)
ybeyYbeY metalloendoribonuclease. (168 aa)
LOC102297662RNA pseudouridine synthase D4. (387 aa)
nop10NOP10 ribonucleoprotein homolog (yeast). (64 aa)
fam207aFamily with sequence similarity 207 member A. (253 aa)
ebna1bp2EBNA1 binding protein 2. (314 aa)
mphosph10U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family. (678 aa)
nop53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (464 aa)
ZNHIT6Zinc finger HIT-type containing 6. (356 aa)
rpusd1RNA pseudouridine synthase domain containing 1. (311 aa)
rpusd2RNA pseudouridine synthase domain containing 2. (576 aa)
prkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3889 aa)
ENSHBUP00000016877Uncharacterized protein. (126 aa)
rpp30Ribonuclease P/MRP 30 subunit. (290 aa)
tfb1mrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (360 aa)
ngdnNeuroguidin, EIF4E binding protein. (331 aa)
mrps11Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family. (196 aa)
rpl7Ribosomal protein L7. (245 aa)
UTP14CUTP14C small subunit processome component. (735 aa)
rpl7l1Ribosomal protein L7-like 1. (283 aa)
kri1KRI1 homolog. (768 aa)
rrp7aRibosomal RNA processing 7 homolog A. (282 aa)
rpf2Ribosome production factor 2 homolog. (308 aa)
pop4Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (221 aa)
ddx47DEAD (Asp-Glu-Ala-Asp) box polypeptide 47; Belongs to the DEAD box helicase family. (480 aa)
znhit3Zinc finger, HIT-type containing 3. (145 aa)
bms1BMS1 ribosome biogenesis factor. (1198 aa)
ddx54ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (475 aa)
wdr46WD repeat domain 46. (598 aa)
wdr75WD repeat domain 75. (798 aa)
ENSHBUP00000020789Uncharacterized protein. (154 aa)
mterf4Mitochondrial transcription termination factor 4. (336 aa)
rrp12Ribosomal RNA processing 12 homolog. (1298 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (195 aa)
LOC102298283Nucleolar protein interacting with the FHA domain of MKI67. (282 aa)
gnl3Guanine nucleotide binding protein-like 3 (nucleolar). (555 aa)
rsl1d1Ribosomal L1 domain containing 1. (359 aa)
exosc9Exosome component 9. (426 aa)
rrp9Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein. (482 aa)
esf1ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae). (746 aa)
helqHelicase, POLQ like. (995 aa)
ercc2Excision repair cross-complementation group 2. (760 aa)
naf1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (302 aa)
nsun3NOP2/Sun RNA methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (466 aa)
mrm2Mitochondrial rRNA methyltransferase 2. (222 aa)
riok3Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (508 aa)
fdxacb1Ferredoxin-fold anticodon binding domain containing 1. (639 aa)
nat10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1035 aa)
LOC102300525Uncharacterized protein. (773 aa)
pin4Peptidyl-prolyl cis-trans isomerase. (127 aa)
wdr3WD repeat domain 3. (941 aa)
mrm1Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae). (293 aa)
LOC102313199Proliferation-associated 2G4, b. (392 aa)
LOC102304338PWP2 small subunit processome component. (935 aa)
ENSHBUP00000004302RIO kinase 1 (yeast). (344 aa)
zcchc4Zinc finger, CCHC domain containing 4. (496 aa)
mak16Protein MAK16 homolog; Belongs to the MAK16 family. (278 aa)
mtrexMtr4 exosome RNA helicase. (1037 aa)
exosc4Exosome component 4. (278 aa)
nol9Nucleolar protein 9. (699 aa)
nsun5NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (495 aa)
mphosph6M-phase phosphoprotein 6. (158 aa)
ddx51DEAD (Asp-Glu-Ala-Asp) box polypeptide 51; Belongs to the DEAD box helicase family. (643 aa)
nsun4NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (392 aa)
eri1Exoribonuclease 1. (341 aa)
pes1Pescadillo. (473 aa)
ddx27DEAD (Asp-Glu-Ala-Asp) box polypeptide 27; Belongs to the DEAD box helicase family. (756 aa)
gemin4Gem (nuclear organelle) associated protein 4. (1114 aa)
pa2g4Proliferation-associated 2G4, a. (391 aa)
utp23UTP23 small subunit processome component. (254 aa)
srfbp1Uncharacterized protein. (539 aa)
npm3Nucleophosmin/nucleoplasmin, 3. (160 aa)
ddx18RNA helicase. (652 aa)
rcl1RNA terminal phosphate cyclase-like 1. (372 aa)
ddx49DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; Belongs to the DEAD box helicase family. (477 aa)
rpp40Ribonuclease P/MRP 40 subunit. (330 aa)
exosc7Exosome component 7. (291 aa)
eif6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (225 aa)
nol6Nucleolar protein 6. (1183 aa)
nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (154 aa)
utp20UTP20 small subunit processome component. (2768 aa)
wdr36WD repeat domain 36. (867 aa)
LOC102296826FSHD region gene 1. (255 aa)
riok2RIO kinase 2 (yeast). (527 aa)
nsa2NSA2 ribosome biogenesis homolog (S. cerevisiae). (291 aa)
rpp38Ribonuclease P/MRP 38 subunit. (264 aa)
exosc6Exosome component 6. (274 aa)
fblFibrillarin. (315 aa)
rrp15Ribosomal RNA processing 15 homolog. (244 aa)
trmt61btRNA methyltransferase 61B. (488 aa)
wdr43WD repeat domain 43. (677 aa)
pop5Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (168 aa)
dimt1rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (345 aa)
ddx10RNA helicase. (852 aa)
ENSHBUP00000010988Zona pellucida glycoprotein d. (381 aa)
trmt112tRNA methyltransferase subunit 11-2. (123 aa)
utp4UTP4 small subunit processome component. (684 aa)
bop1Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (742 aa)
rpf1Ribosome production factor 1 homolog. (349 aa)
dhx37DEAH (Asp-Glu-Ala-His) box polypeptide 37. (1150 aa)
imp4IMP U3 small nucleolar ribonucleoprotein 4. (291 aa)
nol8Nucleolar protein 8. (1231 aa)
emg1EMG1 N1-specific pseudouridine methyltransferase. (254 aa)
nop2NOP2 nucleolar protein homolog (yeast); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (714 aa)
ddx56DEAD (Asp-Glu-Ala-Asp) box helicase 56. (533 aa)
dcaf13Ddb1 and cul4 associated factor 13. (495 aa)
tex10Testis expressed 10. (943 aa)
ddx52DEAD (Asp-Glu-Ala-Asp) box polypeptide 52. (679 aa)
droshaDrosha ribonuclease III. (1224 aa)
rbm34RNA binding motif protein 34. (425 aa)
nol11Nucleolar protein 11. (719 aa)
mettl15Methyltransferase like 15. (258 aa)
nol10Nucleolar protein 10. (720 aa)
pelp1Uncharacterized protein. (906 aa)
ENSHBUP00000029220Uncharacterized protein. (155 aa)
znhit2Zinc finger, HIT-type containing 2. (572 aa)
utp15UTP15 small subunit processome component. (528 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (500 aa)
krr1KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (386 aa)
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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