(45 nodes) Regulation of double-strand break repair via homologous recombination network (Haplochromis burtoni)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	LOC102309076	Enhancer of polycomb homolog. (787 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (827 aa)
	rif1	Replication timing regulatory factor 1. (2354 aa)
	LOC102290288	Uncharacterized protein. (237 aa)
	yeats4	YEATS domain containing 4. (226 aa)
	ENSHBUP00000003488	Uncharacterized protein. (79 aa)
	rmi2	RecQ mediated genome instability 2. (146 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1710 aa)
	helq	Helicase, POLQ like. (995 aa)
	fancb	FA complementation group B. (777 aa)
	trrap	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3770 aa)
	LOC102306769	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (817 aa)
	rtel1	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1137 aa)
	actr2	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
	fbh1	F-box DNA helicase 1. (1076 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2605 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (460 aa)
	wrap53	WD repeat containing, antisense to TP53. (544 aa)
	LOC102313517	Enhancer of polycomb homolog. (837 aa)
	spidr	Scaffold protein involved in DNA repair. (935 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (507 aa)
	brd8	Si:ch211-59d17.3. (796 aa)
	radx	RPA1 related single stranded DNA binding protein. (843 aa)
	timeless	Timeless circadian clock. (1249 aa)
	ENSHBUP00000022412	Uncharacterized protein. (1159 aa)
	vps72	Vacuolar protein sorting 72 homolog a. (356 aa)
	LOC102309979	Bromodomain containing 8. (822 aa)
	mms19	MMS19 homolog, cytosolic iron-sulfur assembly component. (1031 aa)
	dmap1	DNA methyltransferase 1 associated protein 1. (481 aa)
	wdr48	WD repeat domain 48b. (685 aa)
	ercc6	Excision repair cross-complementation group 6. (1439 aa)
	sirt6	Sirtuin 6. (351 aa)
	LOC102291906	Mab-21 domain-containing protein. (516 aa)
	LOC102308466	Zgc:101810; Belongs to the actin family. (394 aa)
	smchd1	Structural maintenance of chromosomes flexible hinge domain containing 1. (1672 aa)
	mrgbp	MRG/MORF4L binding protein. (220 aa)
	parpbp	PARP1 binding protein. (587 aa)
	ENSHBUP00000007412	LEDGF domain-containing protein. (239 aa)
	ENSHBUP00000007464	PWWP domain-containing protein. (110 aa)
	shld2	Si:ch211-134m17.9. (753 aa)
	ENSHBUP00000007880	Pogo transposable element derived with ZNF domain b. (1907 aa)
	terf2ip	Uncharacterized protein. (685 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	arid2	AT rich interactive domain 2 (ARID, RFX-like). (1702 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000003488	LOC102309076	ENSHBUP00000003488	ENSHBUP00000012812	Uncharacterized protein.	Enhancer of polycomb homolog.	0.787
ENSHBUP00000003488	LOC102313517	ENSHBUP00000003488	ENSHBUP00000026331	Uncharacterized protein.	Enhancer of polycomb homolog.	0.787
ENSHBUP00000003488	brd8	ENSHBUP00000003488	ENSHBUP00000023739	Uncharacterized protein.	Si:ch211-59d17.3.	0.519
ENSHBUP00000003488	dmap1	ENSHBUP00000003488	ENSHBUP00000021096	Uncharacterized protein.	DNA methyltransferase 1 associated protein 1.	0.901
ENSHBUP00000003488	ercc6	ENSHBUP00000003488	ENSHBUP00000020553	Uncharacterized protein.	Excision repair cross-complementation group 6.	0.410
ENSHBUP00000003488	mrgbp	ENSHBUP00000003488	ENSHBUP00000012929	Uncharacterized protein.	MRG/MORF4L binding protein.	0.930
ENSHBUP00000003488	trrap	ENSHBUP00000003488	ENSHBUP00000033766	Uncharacterized protein.	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family.	0.884
ENSHBUP00000003488	vps72	ENSHBUP00000003488	ENSHBUP00000000746	Uncharacterized protein.	Vacuolar protein sorting 72 homolog a.	0.846
ENSHBUP00000003488	yeats4	ENSHBUP00000003488	ENSHBUP00000004626	Uncharacterized protein.	YEATS domain containing 4.	0.886
ENSHBUP00000007412	ENSHBUP00000007880	ENSHBUP00000007412	ENSHBUP00000007880	LEDGF domain-containing protein.	Pogo transposable element derived with ZNF domain b.	0.406
ENSHBUP00000007412	ENSHBUP00000022412	ENSHBUP00000007412	ENSHBUP00000022412	LEDGF domain-containing protein.	Uncharacterized protein.	0.406
ENSHBUP00000007412	SETD2	ENSHBUP00000007412	ENSHBUP00000030923	LEDGF domain-containing protein.	SET domain containing 2, histone lysine methyltransferase.	0.422
ENSHBUP00000007412	kdm1a	ENSHBUP00000007412	ENSHBUP00000006760	LEDGF domain-containing protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.512
ENSHBUP00000007464	ENSHBUP00000007880	ENSHBUP00000007464	ENSHBUP00000007880	PWWP domain-containing protein.	Pogo transposable element derived with ZNF domain b.	0.406
ENSHBUP00000007464	ENSHBUP00000022412	ENSHBUP00000007464	ENSHBUP00000022412	PWWP domain-containing protein.	Uncharacterized protein.	0.406
ENSHBUP00000007464	SETD2	ENSHBUP00000007464	ENSHBUP00000030923	PWWP domain-containing protein.	SET domain containing 2, histone lysine methyltransferase.	0.422
ENSHBUP00000007464	kdm1a	ENSHBUP00000007464	ENSHBUP00000006760	PWWP domain-containing protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.512
ENSHBUP00000007880	ENSHBUP00000007412	ENSHBUP00000007880	ENSHBUP00000007412	Pogo transposable element derived with ZNF domain b.	LEDGF domain-containing protein.	0.406
ENSHBUP00000007880	ENSHBUP00000007464	ENSHBUP00000007880	ENSHBUP00000007464	Pogo transposable element derived with ZNF domain b.	PWWP domain-containing protein.	0.406
ENSHBUP00000007880	SETD2	ENSHBUP00000007880	ENSHBUP00000030923	Pogo transposable element derived with ZNF domain b.	SET domain containing 2, histone lysine methyltransferase.	0.416