(41 nodes) Positive regulation of phosphatidylinositol 3-kinase signaling network (Haplochromis burtoni)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (238 aa)
	ENSHBUP00000002195	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (100 aa)
	RELN	Reelin. (3457 aa)
	prr5l	Uncharacterized protein. (367 aa)
	LOC102299999	Uncharacterized protein. (477 aa)
	LOC102292695	G_PROTEIN_RECEP_F1_2 domain-containing protein. (271 aa)
	pdgfb	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (549 aa)
	ENSHBUP00000004966	Kringle domain-containing protein. (100 aa)
	ENSHBUP00000004976	Ig-like domain-containing protein. (129 aa)
	LOC102314301	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (206 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (230 aa)
	ntrk1	Tyrosine-protein kinase receptor. (725 aa)
	ntrk2	Tyrosine-protein kinase receptor. (816 aa)
	unc5b	Unc-5 netrin receptor B. (945 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (715 aa)
	pik3ap1	Phosphoinositide-3-kinase adaptor protein 1. (863 aa)
	LOC102314494	Transforming growth factor beta; Belongs to the TGF-beta family. (420 aa)
	LOC102292655	Homeobox domain-containing protein. (194 aa)
	ube3a	Ubiquitin protein ligase E3A. (833 aa)
	LOC102289130	Olfactomedin-like domain-containing protein. (461 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (463 aa)
	LOC102308578	Fibronectin 1a. (2121 aa)
	LOC102291557	Decorin; May affect the rate of fibrils formation. (358 aa)
	LOC102292391	Uncharacterized protein. (161 aa)
	ncf1	Neutrophil cytosolic factor 1. (397 aa)
	LOC102310023	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (515 aa)
	hax1	HCLS1 associated protein X-1. (299 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (364 aa)
	LOC102289624	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (617 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (896 aa)
	LOC102306739	Tyrosine-protein kinase receptor. (520 aa)
	mydgf	Myeloid-derived growth factor. (210 aa)
	ENSHBUP00000023972	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	F2R	G_PROTEIN_RECEP_F1_2 domain-containing protein. (381 aa)
	LOC102296022	Tyrosine-protein kinase receptor. (804 aa)
	LOC102305404	Protein kinase domain-containing protein. (234 aa)
	myoc	Myocilin. (482 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (509 aa)
	ntrk3	Tyrosine-protein kinase receptor. (813 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (956 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000002195	ENSHBUP00000004966	ENSHBUP00000002195	ENSHBUP00000004966	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Kringle domain-containing protein.	0.552
ENSHBUP00000002195	ENSHBUP00000004976	ENSHBUP00000002195	ENSHBUP00000004976	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Ig-like domain-containing protein.	0.552
ENSHBUP00000002195	LOC102296022	ENSHBUP00000002195	ENSHBUP00000024832	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Tyrosine-protein kinase receptor.	0.460
ENSHBUP00000002195	LOC102305404	ENSHBUP00000002195	ENSHBUP00000031093	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein kinase domain-containing protein.	0.552
ENSHBUP00000002195	LOC102306739	ENSHBUP00000002195	ENSHBUP00000023726	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Tyrosine-protein kinase receptor.	0.460
ENSHBUP00000002195	ntrk1	ENSHBUP00000002195	ENSHBUP00000007261	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Tyrosine-protein kinase receptor.	0.460
ENSHBUP00000002195	ntrk2	ENSHBUP00000002195	ENSHBUP00000008705	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Tyrosine-protein kinase receptor.	0.460
ENSHBUP00000002195	ntrk3	ENSHBUP00000002195	ENSHBUP00000033127	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Tyrosine-protein kinase receptor.	0.460
ENSHBUP00000002195	ror1	ENSHBUP00000002195	ENSHBUP00000033606	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.552
ENSHBUP00000004966	ENSHBUP00000002195	ENSHBUP00000004966	ENSHBUP00000002195	Kringle domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.552
ENSHBUP00000004966	ENSHBUP00000004976	ENSHBUP00000004966	ENSHBUP00000004976	Kringle domain-containing protein.	Ig-like domain-containing protein.	0.454
ENSHBUP00000004966	LOC102291557	ENSHBUP00000004966	ENSHBUP00000017374	Kringle domain-containing protein.	Decorin; May affect the rate of fibrils formation.	0.488
ENSHBUP00000004966	LOC102296022	ENSHBUP00000004966	ENSHBUP00000024832	Kringle domain-containing protein.	Tyrosine-protein kinase receptor.	0.481
ENSHBUP00000004966	LOC102305404	ENSHBUP00000004966	ENSHBUP00000031093	Kringle domain-containing protein.	Protein kinase domain-containing protein.	0.407
ENSHBUP00000004966	LOC102306739	ENSHBUP00000004966	ENSHBUP00000023726	Kringle domain-containing protein.	Tyrosine-protein kinase receptor.	0.481
ENSHBUP00000004966	ntrk1	ENSHBUP00000004966	ENSHBUP00000007261	Kringle domain-containing protein.	Tyrosine-protein kinase receptor.	0.481
ENSHBUP00000004966	ntrk2	ENSHBUP00000004966	ENSHBUP00000008705	Kringle domain-containing protein.	Tyrosine-protein kinase receptor.	0.481
ENSHBUP00000004966	ntrk3	ENSHBUP00000004966	ENSHBUP00000033127	Kringle domain-containing protein.	Tyrosine-protein kinase receptor.	0.481
ENSHBUP00000004966	pdgfc	ENSHBUP00000004966	ENSHBUP00000021461	Kringle domain-containing protein.	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family.	0.507
ENSHBUP00000004966	wnt16	ENSHBUP00000004966	ENSHBUP00000002189	Kringle domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.552