(51 nodes) Clathrin-coated vesicle membrane network (Haplochromis burtoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102299502	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (941 aa)
	LOC102306740	AP-1 complex subunit gamma. (789 aa)
	clhc1	Uncharacterized protein. (426 aa)
	epn3	Epsin 3a. (599 aa)
	LOC102313653	Clathrin interactor 1b. (660 aa)
	tyrp1	Tyrosinase related protein 1. (521 aa)
	ap3b1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1111 aa)
	LOC102294416	ATPase H+ transporting accessory protein 1b. (448 aa)
	atp6ap2	ATPase H+ transporting accessory protein 2. (362 aa)
	ENSHBUP00000006967	ATPase H+ transporting V1 subunit F. (79 aa)
	atp6v0b	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (211 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	ap1g1	AP-1 complex subunit gamma. (820 aa)
	LOC102297694	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1637 aa)
	LOC102300086	Epsin 1. (648 aa)
	LOC102299474	DUF1681 domain-containing protein. (252 aa)
	ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (358 aa)
	synrg	Synergin, gamma. (1440 aa)
	atp6v1a	ATPase H+ transporting V1 subunit A. (617 aa)
	aftph	Clathrin_bdg domain-containing protein. (675 aa)
	atp6v1d	ATPase H+ transporting V1 subunit D. (248 aa)
	LOC102302032	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (916 aa)
	LOC102288530	AP complex subunit beta. (930 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
	LOC102301856	Zgc:194578. (930 aa)
	LOC102303779	NECAP endocytosis associated 1. (278 aa)
	LOC102300764	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
	LOC102298187	Uncharacterized protein. (625 aa)
	LOC102313950	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (866 aa)
	dct	Dopachrome tautomerase. (515 aa)
	epn2	Epsin 2. (576 aa)
	LOC102296338	Aftiphilin a. (791 aa)
	clint1	Clathrin interactor 1a. (644 aa)
	LOC102303963	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1621 aa)
	ap1b1	AP complex subunit beta. (792 aa)
	dennd1a	DENN/MADD domain containing 1A. (831 aa)
	AP3B2	AP-3 complex subunit beta. (1181 aa)
	dab2	DAB adaptor protein 2. (779 aa)
	LOC102310128	Receptor expression-enhancing protein. (186 aa)
	LOC102299830	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1141 aa)
	cltb	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (212 aa)
	atp6v1h	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (484 aa)
	clta	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (232 aa)
	LOC102314210	Tyrosinase-related protein 1b. (543 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
	cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1686 aa)
	ENSHBUP00000032213	Uncharacterized protein. (147 aa)
	ENSHBUP00000033420	Ig-like domain-containing protein. (338 aa)
	ENSHBUP00000034242	Solute carrier family 18 member 3a. (488 aa)
	LOC102303243	Epsin 3b. (597 aa)
	necap2	NECAP endocytosis associated 2. (255 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP3B2	LOC102288530	ENSHBUP00000025343	ENSHBUP00000017128	AP-3 complex subunit beta.	AP complex subunit beta.	0.817
AP3B2	LOC102297694	ENSHBUP00000025343	ENSHBUP00000011690	AP-3 complex subunit beta.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.742
AP3B2	LOC102299474	ENSHBUP00000025343	ENSHBUP00000012454	AP-3 complex subunit beta.	DUF1681 domain-containing protein.	0.619
AP3B2	LOC102302032	ENSHBUP00000025343	ENSHBUP00000016716	AP-3 complex subunit beta.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.911
AP3B2	LOC102303779	ENSHBUP00000025343	ENSHBUP00000017717	AP-3 complex subunit beta.	NECAP endocytosis associated 1.	0.619
AP3B2	LOC102303963	ENSHBUP00000025343	ENSHBUP00000023285	AP-3 complex subunit beta.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.733
AP3B2	LOC102306740	ENSHBUP00000025343	ENSHBUP00000001958	AP-3 complex subunit beta.	AP-1 complex subunit gamma.	0.939
AP3B2	ap1b1	ENSHBUP00000025343	ENSHBUP00000024332	AP-3 complex subunit beta.	AP complex subunit beta.	0.727
AP3B2	ap1g1	ENSHBUP00000025343	ENSHBUP00000011263	AP-3 complex subunit beta.	AP-1 complex subunit gamma.	0.939
AP3B2	ap2m1	ENSHBUP00000025343	ENSHBUP00000013490	AP-3 complex subunit beta.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.490
AP3B2	ap3b1	ENSHBUP00000025343	ENSHBUP00000004948	AP-3 complex subunit beta.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.901
AP3B2	clhc1	ENSHBUP00000025343	ENSHBUP00000002184	AP-3 complex subunit beta.	Uncharacterized protein.	0.694
AP3B2	clta	ENSHBUP00000025343	ENSHBUP00000028996	AP-3 complex subunit beta.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.682
AP3B2	cltb	ENSHBUP00000025343	ENSHBUP00000027473	AP-3 complex subunit beta.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.682
AP3B2	cltc	ENSHBUP00000025343	ENSHBUP00000031853	AP-3 complex subunit beta.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.742
AP3B2	necap2	ENSHBUP00000025343	ENSHBUP00000035332	AP-3 complex subunit beta.	NECAP endocytosis associated 2.	0.632
ATP6V0C	ENSHBUP00000006967	ENSHBUP00000031624	ENSHBUP00000006967	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	ATPase H+ transporting V1 subunit F.	0.995
ATP6V0C	LOC102294416	ENSHBUP00000031624	ENSHBUP00000006336	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	ATPase H+ transporting accessory protein 1b.	0.993
ATP6V0C	LOC102298187	ENSHBUP00000031624	ENSHBUP00000019417	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Uncharacterized protein.	0.991
ATP6V0C	LOC102300764	ENSHBUP00000031624	ENSHBUP00000018620	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.886