(20 nodes) Late endosome to vacuole transport via multivesicular body sorting pathway network (Haplochromis burtoni)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	vps28	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (267 aa)
	TMEM50B	Transmembrane protein 50B. (147 aa)
	chmp4c	Charged multivesicular body protein 4C. (212 aa)
	vps36	Vacuolar protein sorting 36 homolog. (382 aa)
	CHMP4B	Charged multivesicular body protein 4B. (222 aa)
	stam	Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1. (751 aa)
	chmp7	Charged multivesicular body protein 7. (450 aa)
	LEPROT	Leptin receptor overlapping transcript. (170 aa)
	tmem50a	Transmembrane protein 50A. (160 aa)
	LOC102304856	Leptin receptor overlapping transcript like 1. (132 aa)
	LOC102308017	Charged multivesicular body protein 4Bb. (220 aa)
	chmp6	Charged multivesicular body protein 6. (205 aa)
	LOC102300456	Charged multivesicular body protein 6a. (217 aa)
	snf8	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (257 aa)
	vps25	Vacuolar protein sorting 25 homolog. (174 aa)
	vta1	Vesicle (multivesicular body) trafficking 1. (253 aa)
	chmp5	Charged multivesicular body protein 5a. (220 aa)
	ptpn23	Protein tyrosine phosphatase, non-receptor type 23, a. (1866 aa)
	LOC102302510	Charged multivesicular body protein 5b. (219 aa)
	LOC102296491	Uncharacterized protein. (268 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHMP4B	LOC102300456	ENSHBUP00000009734	ENSHBUP00000023186	Charged multivesicular body protein 4B.	Charged multivesicular body protein 6a.	0.954
CHMP4B	LOC102302510	ENSHBUP00000009734	ENSHBUP00000030819	Charged multivesicular body protein 4B.	Charged multivesicular body protein 5b.	0.950
CHMP4B	LOC102308017	ENSHBUP00000009734	ENSHBUP00000020446	Charged multivesicular body protein 4B.	Charged multivesicular body protein 4Bb.	0.810
CHMP4B	chmp4c	ENSHBUP00000009734	ENSHBUP00000007492	Charged multivesicular body protein 4B.	Charged multivesicular body protein 4C.	0.828
CHMP4B	chmp5	ENSHBUP00000009734	ENSHBUP00000028083	Charged multivesicular body protein 4B.	Charged multivesicular body protein 5a.	0.950
CHMP4B	chmp6	ENSHBUP00000009734	ENSHBUP00000022250	Charged multivesicular body protein 4B.	Charged multivesicular body protein 6.	0.954
CHMP4B	chmp7	ENSHBUP00000009734	ENSHBUP00000011863	Charged multivesicular body protein 4B.	Charged multivesicular body protein 7.	0.950
CHMP4B	ptpn23	ENSHBUP00000009734	ENSHBUP00000030263	Charged multivesicular body protein 4B.	Protein tyrosine phosphatase, non-receptor type 23, a.	0.986
CHMP4B	snf8	ENSHBUP00000009734	ENSHBUP00000023638	Charged multivesicular body protein 4B.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.922
CHMP4B	vps25	ENSHBUP00000009734	ENSHBUP00000025122	Charged multivesicular body protein 4B.	Vacuolar protein sorting 25 homolog.	0.906
CHMP4B	vps28	ENSHBUP00000009734	ENSHBUP00000001812	Charged multivesicular body protein 4B.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.788
CHMP4B	vps36	ENSHBUP00000009734	ENSHBUP00000007864	Charged multivesicular body protein 4B.	Vacuolar protein sorting 36 homolog.	0.883
CHMP4B	vta1	ENSHBUP00000009734	ENSHBUP00000027553	Charged multivesicular body protein 4B.	Vesicle (multivesicular body) trafficking 1.	0.897
LEPROT	TMEM50B	ENSHBUP00000013190	ENSHBUP00000002538	Leptin receptor overlapping transcript.	Transmembrane protein 50B.	0.924
LEPROT	tmem50a	ENSHBUP00000013190	ENSHBUP00000018415	Leptin receptor overlapping transcript.	Transmembrane protein 50A.	0.924
LOC102296491	LOC102300456	ENSHBUP00000035342	ENSHBUP00000023186	Uncharacterized protein.	Charged multivesicular body protein 6a.	0.868
LOC102296491	LOC102302510	ENSHBUP00000035342	ENSHBUP00000030819	Uncharacterized protein.	Charged multivesicular body protein 5b.	0.877
LOC102296491	chmp5	ENSHBUP00000035342	ENSHBUP00000028083	Uncharacterized protein.	Charged multivesicular body protein 5a.	0.877
LOC102296491	chmp6	ENSHBUP00000035342	ENSHBUP00000022250	Uncharacterized protein.	Charged multivesicular body protein 6.	0.868
LOC102296491	chmp7	ENSHBUP00000035342	ENSHBUP00000011863	Uncharacterized protein.	Charged multivesicular body protein 7.	0.945