(8 nodes) Mitotic DNA replication checkpoint signaling network (Haplochromis burtoni)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

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gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	rad17	RAD17 checkpoint clamp loader component. (692 aa)
	ticrr	Treslin_N domain-containing protein. (1869 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (285 aa)
	CLSPN	Claspin. (1353 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1538 aa)
	ZNF830	Zinc finger protein 830. (347 aa)
	cdc6	Cell division cycle 6 homolog (S. cerevisiae). (429 aa)
	orc1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (898 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLSPN	cdc6	ENSHBUP00000021692	ENSHBUP00000005263	Claspin.	Cell division cycle 6 homolog (S. cerevisiae).	0.905
CLSPN	hus1	ENSHBUP00000021692	ENSHBUP00000023029	Claspin.	Checkpoint protein; Belongs to the HUS1 family.	0.605
CLSPN	orc1	ENSHBUP00000021692	ENSHBUP00000033578	Claspin.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.936
CLSPN	rad17	ENSHBUP00000021692	ENSHBUP00000034015	Claspin.	RAD17 checkpoint clamp loader component.	0.692
CLSPN	ticrr	ENSHBUP00000021692	ENSHBUP00000026074	Claspin.	Treslin_N domain-containing protein.	0.648
CLSPN	topbp1	ENSHBUP00000021692	ENSHBUP00000013107	Claspin.	DNA topoisomerase II binding protein 1.	0.858
ZNF830	ticrr	ENSHBUP00000005507	ENSHBUP00000026074	Zinc finger protein 830.	Treslin_N domain-containing protein.	0.646
cdc6	CLSPN	ENSHBUP00000005263	ENSHBUP00000021692	Cell division cycle 6 homolog (S. cerevisiae).	Claspin.	0.905
cdc6	orc1	ENSHBUP00000005263	ENSHBUP00000033578	Cell division cycle 6 homolog (S. cerevisiae).	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.999
cdc6	rad17	ENSHBUP00000005263	ENSHBUP00000034015	Cell division cycle 6 homolog (S. cerevisiae).	RAD17 checkpoint clamp loader component.	0.728
cdc6	ticrr	ENSHBUP00000005263	ENSHBUP00000026074	Cell division cycle 6 homolog (S. cerevisiae).	Treslin_N domain-containing protein.	0.633
cdc6	topbp1	ENSHBUP00000005263	ENSHBUP00000013107	Cell division cycle 6 homolog (S. cerevisiae).	DNA topoisomerase II binding protein 1.	0.647
hus1	CLSPN	ENSHBUP00000023029	ENSHBUP00000021692	Checkpoint protein; Belongs to the HUS1 family.	Claspin.	0.605
hus1	rad17	ENSHBUP00000023029	ENSHBUP00000034015	Checkpoint protein; Belongs to the HUS1 family.	RAD17 checkpoint clamp loader component.	0.996
hus1	topbp1	ENSHBUP00000023029	ENSHBUP00000013107	Checkpoint protein; Belongs to the HUS1 family.	DNA topoisomerase II binding protein 1.	0.921
orc1	CLSPN	ENSHBUP00000033578	ENSHBUP00000021692	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Claspin.	0.936
orc1	cdc6	ENSHBUP00000033578	ENSHBUP00000005263	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Cell division cycle 6 homolog (S. cerevisiae).	0.999
orc1	rad17	ENSHBUP00000033578	ENSHBUP00000034015	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	RAD17 checkpoint clamp loader component.	0.626
orc1	ticrr	ENSHBUP00000033578	ENSHBUP00000026074	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Treslin_N domain-containing protein.	0.419
rad17	CLSPN	ENSHBUP00000034015	ENSHBUP00000021692	RAD17 checkpoint clamp loader component.	Claspin.	0.692