(60 nodes) Cellular response to UV network (Haplochromis burtoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ppid	Peptidylprolyl isomerase D. (371 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (692 aa)
	LOC102312014	Rhomboid domain-containing protein. (330 aa)
	LOC102297268	Uncharacterized protein. (204 aa)
	opn3	Opsin 3. (388 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (874 aa)
	LOC102301770	Hyaluronidase. (441 aa)
	LOC102293834	Mitogen-activated protein kinase. (364 aa)
	nfatc4	Nuclear factor of activated T cells 4. (849 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (827 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (444 aa)
	ddb1	Damage-specific DNA binding protein 1. (1140 aa)
	LOC102310072	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (290 aa)
	polk	Polymerase (DNA directed) kappa. (875 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (602 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	tmem161a	Transmembrane protein 161A. (496 aa)
	actr5	Actin related protein 5; Belongs to the actin family. (624 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (715 aa)
	rhno1	Si:ch73-352p4.5. (295 aa)
	LOC102289691	Zgc:153993. (202 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3139 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (428 aa)
	LOC102313452	Opsin 5; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	ercc4	Excision repair cross-complementation group 4. (899 aa)
	opn5	Opsin 8, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (364 aa)
	impact	Impact RWD domain protein. (319 aa)
	bmf	Uncharacterized protein. (163 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1659 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (865 aa)
	rhbdd1	Rhomboid domain containing 1. (362 aa)
	ep300	E1A binding protein p300 b. (2764 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (296 aa)
	eif2s1	Eukaryotic translation initiation factor 2, subunit 1 alpha b. (315 aa)
	pold1	DNA polymerase. (1129 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (693 aa)
	polh	Polymerase (DNA directed), eta. (738 aa)
	ENSHBUP00000019258	Fibrinogen C-terminal domain-containing protein. (228 aa)
	noc2l	NOC2-like nucleolar associated transcriptional repressor. (748 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (436 aa)
	ino80	INO80 complex ATPase subunit. (1497 aa)
	LOC102294305	Mitogen-activated protein kinase. (361 aa)
	LOC102306757	E1A binding protein p300 a. (2600 aa)
	LOC102299633	Mitogen-activated protein kinase. (361 aa)
	ercc1	Excision repair cross-complementation group 1. (352 aa)
	LOC102298462	Fibrinogen C-terminal domain-containing protein. (239 aa)
	LOC102312217	Fibrinogen C-terminal domain-containing protein. (124 aa)
	LOC102291667	Aurora kinase B; Belongs to the protein kinase superfamily. (305 aa)
	LOC102293257	Uncharacterized protein. (2253 aa)
	LOC102310684	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (283 aa)
	LOC102310381	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1383 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1063 aa)
	LOC102293699	Fibrinogen C-terminal domain-containing protein. (248 aa)
	LOC102308559	Fibrinogen C-terminal domain-containing protein. (247 aa)
	mc1r	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (325 aa)
	LOC102306633	CREB binding protein a. (2475 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (460 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (671 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (271 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK4	eif2s1	ENSHBUP00000014741	ENSHBUP00000016452	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2, subunit 1 alpha b.	0.991
EIF2AK4	impact	ENSHBUP00000014741	ENSHBUP00000014517	Eukaryotic translation initiation factor 2 alpha kinase 4.	Impact RWD domain protein.	0.579
EIF2AK4	sirt1	ENSHBUP00000014741	ENSHBUP00000009767	Eukaryotic translation initiation factor 2 alpha kinase 4.	Deacetylase sirtuin-type domain-containing protein.	0.407
LOC102289691	LOC102297268	ENSHBUP00000011743	ENSHBUP00000001523	Zgc:153993.	Uncharacterized protein.	0.986
LOC102289691	bmf	ENSHBUP00000011743	ENSHBUP00000014606	Zgc:153993.	Uncharacterized protein.	0.732
LOC102289691	casp9	ENSHBUP00000011743	ENSHBUP00000032452	Zgc:153993.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.586
LOC102289691	sirt1	ENSHBUP00000011743	ENSHBUP00000009767	Zgc:153993.	Deacetylase sirtuin-type domain-containing protein.	0.510
LOC102291667	chek1	ENSHBUP00000025010	ENSHBUP00000030727	Aurora kinase B; Belongs to the protein kinase superfamily.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.437
LOC102291667	ino80	ENSHBUP00000025010	ENSHBUP00000020298	Aurora kinase B; Belongs to the protein kinase superfamily.	INO80 complex ATPase subunit.	0.442
LOC102291667	noc2l	ENSHBUP00000025010	ENSHBUP00000019267	Aurora kinase B; Belongs to the protein kinase superfamily.	NOC2-like nucleolar associated transcriptional repressor.	0.726
LOC102291667	parp1	ENSHBUP00000025010	ENSHBUP00000008939	Aurora kinase B; Belongs to the protein kinase superfamily.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.414
LOC102291667	pold1	ENSHBUP00000025010	ENSHBUP00000017205	Aurora kinase B; Belongs to the protein kinase superfamily.	DNA polymerase.	0.572
LOC102293257	LOC102306633	ENSHBUP00000025589	ENSHBUP00000030717	Uncharacterized protein.	CREB binding protein a.	0.849
LOC102293257	LOC102306757	ENSHBUP00000025589	ENSHBUP00000020755	Uncharacterized protein.	E1A binding protein p300 a.	0.986
LOC102293257	casp9	ENSHBUP00000025589	ENSHBUP00000032452	Uncharacterized protein.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.469
LOC102293257	ddb1	ENSHBUP00000025589	ENSHBUP00000007296	Uncharacterized protein.	Damage-specific DNA binding protein 1.	0.422
LOC102293257	ep300	ENSHBUP00000025589	ENSHBUP00000015535	Uncharacterized protein.	E1A binding protein p300 b.	0.986
LOC102293257	ino80	ENSHBUP00000025589	ENSHBUP00000020298	Uncharacterized protein.	INO80 complex ATPase subunit.	0.472
LOC102293257	kdm1a	ENSHBUP00000025589	ENSHBUP00000006760	Uncharacterized protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.698
LOC102293257	parp1	ENSHBUP00000025589	ENSHBUP00000008939	Uncharacterized protein.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.567