64 items (Haplochromis burtoni) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ajuba	Ajuba LIM protein. (733 aa)
	fzd8	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
	LOC102296557	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
	ENSHBUP00000001260	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (324 aa)
	LOC102314283	Transforming growth factor beta; Belongs to the TGF-beta family. (383 aa)
	map3k13	Mitogen-activated protein kinase kinase kinase. (1008 aa)
	axin1	Axin 1. (825 aa)
	LOC102299736	Interleukin-1. (114 aa)
	ENSHBUP00000002232	Uncharacterized protein. (176 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (453 aa)
	pik3r5	Phosphoinositide-3-kinase, regulatory subunit 5. (850 aa)
	LOC102314677	Protein kinase domain-containing protein. (354 aa)
	LOC102294502	Uncharacterized protein. (772 aa)
	pdcd10	Programmed cell death 10a. (198 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (478 aa)
	il34	Interleukin 34. (257 aa)
	pdgfb	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (549 aa)
	LOC102314301	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (206 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (230 aa)
	map3k4	Mitogen-activated protein kinase kinase kinase 4. (1486 aa)
	sash1	SAM and SH3 domain containing 1a. (1382 aa)
	LOC102308448	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
	LOC102309602	Tumor necrosis factor b (TNF superfamily, member 2). (247 aa)
	LOC102302149	Uncharacterized protein. (827 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (438 aa)
	LOC102307308	SAM and SH3 domain containing 1b. (1092 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (533 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (265 aa)
	tpd52l1	Tpd52 like 1. (279 aa)
	ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (293 aa)
	fzd5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
	ENSHBUP00000015748	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (129 aa)
	ENSHBUP00000016426	Protein kinase domain-containing protein. (84 aa)
	LOC102310436	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (580 aa)
	LOC102291272	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1095 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (854 aa)
	LOC102304742	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	LOC102305789	Transforming growth factor, alpha. (254 aa)
	LOC102310023	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (515 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (364 aa)
	dusp19	Dual specificity phosphatase 19a. (208 aa)
	LOC102288611	Teneurin transmembrane protein 1. (2761 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (510 aa)
	LOC102304734	CD40 molecule, TNF receptor superfamily member 5. (308 aa)
	LOC102296736	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (414 aa)
	LOC102304962	Programmed cell death 10b. (210 aa)
	fgf18	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC102288968	Epithelial mitogen homolog (mouse). (164 aa)
	ern1	Endoplasmic reticulum to nucleus signaling 1. (1077 aa)
	nek10	NIMA-related kinase 10. (1060 aa)
	LOC102289294	Fibroblast growth factor receptor. (836 aa)
	nox4	FAD-binding FR-type domain-containing protein. (497 aa)
	drd4	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (402 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2426 aa)
	LOC102289726	Uncharacterized protein. (203 aa)
	pik3cg	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1122 aa)
	edn1	Endothelin 1. (201 aa)
	LOC102292960	Uncharacterized protein. (844 aa)
	LOC102293702	Dickkopf WNT signaling pathway inhibitor 1a. (253 aa)
	LOC102289510	Endoplasmic reticulum to nucleus signaling 2. (979 aa)
	LOC102292008	Uncharacterized protein. (458 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000001260	edn1	ENSHBUP00000001260	ENSHBUP00000031465	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.814
ENSHBUP00000001260	htr2b	ENSHBUP00000001260	ENSHBUP00000004654	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled.	0.546
ENSHBUP00000002232	LOC102293702	ENSHBUP00000002232	ENSHBUP00000032439	Uncharacterized protein.	Dickkopf WNT signaling pathway inhibitor 1a.	0.648
ENSHBUP00000002232	LOC102294502	ENSHBUP00000002232	ENSHBUP00000003227	Uncharacterized protein.	Uncharacterized protein.	0.402
ENSHBUP00000002232	LOC102304734	ENSHBUP00000002232	ENSHBUP00000025312	Uncharacterized protein.	CD40 molecule, TNF receptor superfamily member 5.	0.477
ENSHBUP00000002232	LOC102309602	ENSHBUP00000002232	ENSHBUP00000008282	Uncharacterized protein.	Tumor necrosis factor b (TNF superfamily, member 2).	0.817
ENSHBUP00000002232	LOC102314283	ENSHBUP00000002232	ENSHBUP00000001653	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.471
ENSHBUP00000015748	LOC102289294	ENSHBUP00000015748	ENSHBUP00000029158	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Fibroblast growth factor receptor.	0.867
ENSHBUP00000015748	LOC102292008	ENSHBUP00000015748	ENSHBUP00000032940	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein.	0.867
ENSHBUP00000015748	LOC102310023	ENSHBUP00000015748	ENSHBUP00000020117	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	0.800
ENSHBUP00000015748	pdgfb	ENSHBUP00000015748	ENSHBUP00000004802	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family.	0.800
ENSHBUP00000015748	pdgfc	ENSHBUP00000015748	ENSHBUP00000021461	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family.	0.855
ENSHBUP00000016426	LOC102291272	ENSHBUP00000016426	ENSHBUP00000019229	Protein kinase domain-containing protein.	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family.	0.508
ENSHBUP00000016426	LOC102292960	ENSHBUP00000016426	ENSHBUP00000031990	Protein kinase domain-containing protein.	Uncharacterized protein.	0.412
ENSHBUP00000016426	LOC102304734	ENSHBUP00000016426	ENSHBUP00000025312	Protein kinase domain-containing protein.	CD40 molecule, TNF receptor superfamily member 5.	0.561
ENSHBUP00000016426	LOC102309602	ENSHBUP00000016426	ENSHBUP00000008282	Protein kinase domain-containing protein.	Tumor necrosis factor b (TNF superfamily, member 2).	0.968
ENSHBUP00000016426	ajuba	ENSHBUP00000016426	ENSHBUP00000033331	Protein kinase domain-containing protein.	Ajuba LIM protein.	0.419
ENSHBUP00000016426	axin1	ENSHBUP00000016426	ENSHBUP00000001941	Protein kinase domain-containing protein.	Axin 1.	0.412
ENSHBUP00000016426	map2k5	ENSHBUP00000016426	ENSHBUP00000010497	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	0.669
ENSHBUP00000016426	map2k7	ENSHBUP00000016426	ENSHBUP00000002241	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase 7.	0.941