(63 nodes) Mitotic DNA damage checkpoint signaling network (Haplochromis burtoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (695 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (526 aa)
	cdca7l	Cell division cycle associated 7b. (402 aa)
	ENSHBUP00000033958	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (229 aa)
	LOC102291828	TAO kinase 1b. (1013 aa)
	LOC102313474	Uncharacterized protein. (197 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1001 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (464 aa)
	wac	WW domain containing adaptor with coiled-coil a. (543 aa)
	abraxas1	Abraxas 1, BRCA1 A complex subunit. (346 aa)
	LOC102312576	Uncharacterized protein. (446 aa)
	ENSHBUP00000002129	Uncharacterized protein. (194 aa)
	LOC102292915	Uncharacterized protein. (205 aa)
	ENSHBUP00000002426	WW domain-containing protein. (156 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (874 aa)
	brca1	Uncharacterized protein. (1388 aa)
	babam1	BRISC and BRCA1 A complex member 1. (378 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (506 aa)
	LOC102300113	WD_REPEATS_REGION domain-containing protein. (489 aa)
	LOC102294096	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (294 aa)
	ENSHBUP00000005048	TAN domain-containing protein. (177 aa)
	ENSHBUP00000005062	Uncharacterized protein. (143 aa)
	ZNF830	Zinc finger protein 830. (347 aa)
	taok2	Protein kinase domain-containing protein. (1248 aa)
	taok3	TAO kinase 3a. (900 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (650 aa)
	uimc1	RAP80_UIM domain-containing protein. (848 aa)
	babam2	BRISC and BRCA1 A complex member 2. (400 aa)
	ENSHBUP00000011390	BRCA1/BRCA2-containing complex, subunit 3. (266 aa)
	foxn3	Checkpoint suppressor 1. (486 aa)
	LOC102302828	TAO kinase 2a. (1136 aa)
	mfsd11	Major facilitator superfamily domain containing 11. (461 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (307 aa)
	casp2	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (525 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1538 aa)
	LOC102292505	Fizzy/cell division cycle 20 related 1b. (532 aa)
	ENSHBUP00000013671	Reverse transcriptase domain-containing protein. (397 aa)
	blm	BLM RecQ like helicase. (1405 aa)
	ENSHBUP00000015244	Uncharacterized protein. (201 aa)
	rint1	RAD50 interactor 1. (740 aa)
	dtl	Denticleless E3 ubiquitin protein ligase homolog (Drosophila). (661 aa)
	LOC102289121	TAO kinase 1a. (1021 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3889 aa)
	LOC102314522	P53-induced death domain protein 1. (978 aa)
	cdca7	Cell division cycle associated 7a. (401 aa)
	ENSHBUP00000017414	TAO kinase 3b. (496 aa)
	chek2	Checkpoint kinase 2. (521 aa)
	FZR1	Fizzy/cell division cycle 20 related 1a. (496 aa)
	rad9b	RAD9 checkpoint clamp component B. (390 aa)
	CLSPN	Claspin. (1353 aa)
	rfwd3	Ring finger and WD repeat domain 3. (708 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (285 aa)
	nbn	Nibrin. (779 aa)
	ENSHBUP00000025640	Reverse transcriptase domain-containing protein. (416 aa)
	ticrr	Treslin_N domain-containing protein. (1869 aa)
	ENSHBUP00000027528	Uncharacterized protein. (252 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa)
	fancd2	FA complementation group D2. (1335 aa)
	fbxo31	F-box protein 31. (585 aa)
	ENSHBUP00000029115	Uncharacterized protein. (166 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (460 aa)
	eme2	ERCC4 domain-containing protein. (276 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLSPN	ENSHBUP00000005048	ENSHBUP00000021692	ENSHBUP00000005048	Claspin.	TAN domain-containing protein.	0.450
CLSPN	ENSHBUP00000005062	ENSHBUP00000021692	ENSHBUP00000005062	Claspin.	Uncharacterized protein.	0.450
CLSPN	ENSHBUP00000033958	ENSHBUP00000021692	ENSHBUP00000033958	Claspin.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.941
CLSPN	blm	ENSHBUP00000021692	ENSHBUP00000014122	Claspin.	BLM RecQ like helicase.	0.707
CLSPN	brca1	ENSHBUP00000021692	ENSHBUP00000003104	Claspin.	Uncharacterized protein.	0.858
CLSPN	casp2	ENSHBUP00000021692	ENSHBUP00000012935	Claspin.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.678
CLSPN	cdca7	ENSHBUP00000021692	ENSHBUP00000017327	Claspin.	Cell division cycle associated 7a.	0.604
CLSPN	cdca7l	ENSHBUP00000021692	ENSHBUP00000033360	Claspin.	Cell division cycle associated 7b.	0.604
CLSPN	cdk1	ENSHBUP00000021692	ENSHBUP00000012669	Claspin.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.693
CLSPN	chek1	ENSHBUP00000021692	ENSHBUP00000030727	Claspin.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.990
CLSPN	chek2	ENSHBUP00000021692	ENSHBUP00000017690	Claspin.	Checkpoint kinase 2.	0.545
CLSPN	fancd2	ENSHBUP00000021692	ENSHBUP00000028381	Claspin.	FA complementation group D2.	0.654
CLSPN	hus1	ENSHBUP00000021692	ENSHBUP00000023029	Claspin.	Checkpoint protein; Belongs to the HUS1 family.	0.605
CLSPN	rad9a	ENSHBUP00000021692	ENSHBUP00000027588	Claspin.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.697
CLSPN	rad9b	ENSHBUP00000021692	ENSHBUP00000021654	Claspin.	RAD9 checkpoint clamp component B.	0.697
CLSPN	ticrr	ENSHBUP00000021692	ENSHBUP00000026074	Claspin.	Treslin_N domain-containing protein.	0.648
CLSPN	topbp1	ENSHBUP00000021692	ENSHBUP00000013107	Claspin.	DNA topoisomerase II binding protein 1.	0.858
ENSHBUP00000005048	CLSPN	ENSHBUP00000005048	ENSHBUP00000021692	TAN domain-containing protein.	Claspin.	0.450
ENSHBUP00000005048	ENSHBUP00000005062	ENSHBUP00000005048	ENSHBUP00000005062	TAN domain-containing protein.	Uncharacterized protein.	0.923
ENSHBUP00000005048	ENSHBUP00000011390	ENSHBUP00000005048	ENSHBUP00000011390	TAN domain-containing protein.	BRCA1/BRCA2-containing complex, subunit 3.	0.687