STRINGSTRING
ppp1cc ppp1cc dmc1 dmc1 meaf6 meaf6 smc4 smc4 phf6 phf6 atrx atrx bub1 bub1 LOC102290684 LOC102290684 tp53bp1 tp53bp1 cenpx cenpx sgo1 sgo1 ska3 ska3 LOC102295711 LOC102295711 ENSHBUP00000002926 ENSHBUP00000002926 nsl1 nsl1 LOC102294619 LOC102294619 bod1 bod1 cfdp1 cfdp1 cenpm cenpm spdl1 spdl1 tpr tpr cbx5 cbx5 LOC102293403 LOC102293403 spc25 spc25 ppp2cb ppp2cb ENSHBUP00000005048 ENSHBUP00000005048 ENSHBUP00000005062 ENSHBUP00000005062 trappc12 trappc12 ENSHBUP00000005237 ENSHBUP00000005237 bod1l1 bod1l1 ENSHBUP00000005316 ENSHBUP00000005316 zbtb48 zbtb48 rif1 rif1 ENSHBUP00000005892 ENSHBUP00000005892 kntc1 kntc1 ENSHBUP00000006166 ENSHBUP00000006166 ercc6l ercc6l mis18a mis18a kdm1a kdm1a ENSHBUP00000007056 ENSHBUP00000007056 znf827 znf827 orc4 orc4 ckap5 ckap5 LOC102304439 LOC102304439 LOC102304128 LOC102304128 terf2ip terf2ip smc6 smc6 hells hells ENSHBUP00000009123 ENSHBUP00000009123 ENSHBUP00000009143 ENSHBUP00000009143 LOC102310266 LOC102310266 LOC102291259 LOC102291259 LOC102295202 LOC102295202 knl1 knl1 dscc1 dscc1 LOC102311156 LOC102311156 LOC102289767 LOC102289767 zwilch zwilch terb2 terb2 dctn1 dctn1 LOC102296060 LOC102296060 rassf2 rassf2 ENSHBUP00000012738 ENSHBUP00000012738 LOC102314648 LOC102314648 DCTN6 DCTN6 ncapd2 ncapd2 LOC102301954 LOC102301954 cenpi cenpi bub1b bub1b ercc4 ercc4 cenpn cenpn LOC102304191 LOC102304191 ska2 ska2 LOC102303125 LOC102303125 majin majin LOC102308912 LOC102308912 nsmce1 nsmce1 LOC102299901 LOC102299901 fbxo28 fbxo28 mis12 mis12 rnf8 rnf8 clasp2 clasp2 ZNF207 ZNF207 ENSHBUP00000016535 ENSHBUP00000016535 anapc16 anapc16 cenpf cenpf hat1 hat1 bub3 bub3 LOC102304158 LOC102304158 pold1 pold1 ENSHBUP00000017345 ENSHBUP00000017345 LOC102296327 LOC102296327 LOC102295763 LOC102295763 cenpk cenpk rcc2 rcc2 LOC102296990 LOC102296990 seh1l seh1l fam193a fam193a LOC102291534 LOC102291534 ENSHBUP00000018665 ENSHBUP00000018665 ppp2ca ppp2ca spc24 spc24 sirt6 sirt6 ENSHBUP00000019957 ENSHBUP00000019957 rassf4 rassf4 smc5 smc5 mki67 mki67 DYNLT3 DYNLT3 LOC102299711 LOC102299711 KIF18A KIF18A RAD21 RAD21 nuf2 nuf2 znf276 znf276 clasp1 clasp1 stn1 stn1 cdca8 cdca8 LOC102298446 LOC102298446 nudcd2 nudcd2 brca2 brca2 BAZ1A BAZ1A ercc1 ercc1 cep131 cep131 chrac1 chrac1 xrcc5 xrcc5 ten1 ten1 rad50 rad50 ncapg ncapg smc1a smc1a LOC102295920 LOC102295920 ENSHBUP00000023677 ENSHBUP00000023677 ska1 ska1 CBX1 CBX1 nbn nbn LOC102301011 LOC102301011 phf11 phf11 cenpt cenpt ENSHBUP00000024905 ENSHBUP00000024905 LOC102291667 LOC102291667 nup133 nup133 xpo1 xpo1 LOC102291296 LOC102291296 rad51 rad51 spo11 spo11 LOC102302286 LOC102302286 spout1 spout1 znf330 znf330 ndc80 ndc80 LOC102311631 LOC102311631 nsmce4a nsmce4a nup43 nup43 ENSHBUP00000027738 ENSHBUP00000027738 LOC102300936 LOC102300936 LOC102290810 LOC102290810 wrap53 wrap53 mtbp mtbp lrwd1 lrwd1 cenph cenph LOC102297012 LOC102297012 nsmce2 nsmce2 fmr1 fmr1 kdm4a kdm4a suv39h1 suv39h1 oip5 oip5 rad51d rad51d ENSHBUP00000029795 ENSHBUP00000029795 ncapd3 ncapd3 ENSHBUP00000029831 ENSHBUP00000029831 dctn3 dctn3 ttk ttk cenpw cenpw dhx36 dhx36 slx4 slx4 dctn5 dctn5 smc3 smc3 nek2 nek2 rangap1 rangap1 cdt1 cdt1 mad1l1 mad1l1 xrcc1 xrcc1 ENSHBUP00000032172 ENSHBUP00000032172 mre11 mre11 CBX1-2 CBX1-2 ENSHBUP00000032296 ENSHBUP00000032296 tert tert incenp incenp recql4 recql4 zw10 zw10 LOC102311321 LOC102311321 terf2 terf2 orc1 orc1 NDE1 NDE1 smg6 smg6 dnmt1 dnmt1 cenpv cenpv LOC102290331 LOC102290331 dclre1b dclre1b orc2 orc2 gpatch11 gpatch11 rec8 rec8
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ppp1ccSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
meaf6MYST/Esa1-associated factor 6. (203 aa)
smc4Structural maintenance of chromosomes protein. (1296 aa)
phf6PHD finger protein 6. (386 aa)
atrxATRX chromatin remodeler. (1871 aa)
bub1BUB1 mitotic checkpoint serine/threonine kinase. (1199 aa)
LOC102290684Serine/threonine-protein phosphatase. (309 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1710 aa)
cenpxCentromere protein X. (89 aa)
sgo1Shugoshin_C domain-containing protein. (718 aa)
ska3Spindle and kinetochore associated complex subunit 3. (603 aa)
LOC102295711Baculoviral IAP repeat containing 5b. (144 aa)
ENSHBUP00000002926ATRX chromatin remodeler, like. (1369 aa)
nsl1NSL1 component of MIS12 kinetochore complex. (258 aa)
LOC102294619NudE neurodevelopment protein 1-like 1b. (340 aa)
bod1Uncharacterized protein. (426 aa)
cfdp1Craniofacial development protein 1; May play a role during embryogenesis. (303 aa)
cenpmProliferation associated nuclear element. (184 aa)
spdl1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (574 aa)
tprTranslocated promoter region b, nuclear basket protein. (2192 aa)
cbx5Chromobox homolog 5 (HP1 alpha homolog, Drosophila). (199 aa)
LOC102293403Uncharacterized protein. (194 aa)
spc25SPC25 component of NDC80 kinetochore complex. (236 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
ENSHBUP00000005048TAN domain-containing protein. (177 aa)
ENSHBUP00000005062Uncharacterized protein. (143 aa)
trappc12Trafficking protein particle complex 12. (805 aa)
ENSHBUP00000005237PHD-type domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (526 aa)
bod1l1Uncharacterized protein. (1272 aa)
ENSHBUP00000005316Uncharacterized protein. (172 aa)
zbtb48Zinc finger and BTB domain containing 48. (712 aa)
rif1Replication timing regulatory factor 1. (2354 aa)
ENSHBUP00000005892TROVE domain-containing protein. (927 aa)
kntc1Kinetochore associated 1. (2083 aa)
ENSHBUP00000006166Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (154 aa)
ercc6lExcision repair cross-complementation group 6-like. (1228 aa)
mis18aMIS18 kinetochore protein A. (233 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (827 aa)
ENSHBUP00000007056Nucleoporin 37. (313 aa)
znf827Zinc finger protein 827. (1527 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (498 aa)
ckap5Cytoskeleton associated protein 5. (1599 aa)
LOC102304439Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (332 aa)
LOC102304128SET domain-containing protein. (2044 aa)
terf2ipUncharacterized protein. (685 aa)
smc6Si:dkey-119f1.1. (1088 aa)
hellsHelicase, lymphoid specific. (854 aa)
ENSHBUP00000009123Uncharacterized protein. (264 aa)
ENSHBUP00000009143AAA_23 domain-containing protein. (92 aa)
LOC102310266RAD21 cohesin complex component like 1. (547 aa)
LOC102291259Poly [ADP-ribose] polymerase. (1263 aa)
LOC102295202CAP-Gly domain-containing protein. (1259 aa)
knl1Knl1_RWD_C domain-containing protein. (1829 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
LOC102311156Structural maintenance of chromosomes 6. (1089 aa)
LOC102289767RAD21 cohesin complex component a. (636 aa)
zwilchZwilch kinetochore protein. (609 aa)
terb2Telomere repeat binding bouquet formation protein 2. (203 aa)
dctn1Dynactin 1b. (1225 aa)
LOC102296060DNA (cytosine-5-)-methyltransferase 3 alpha a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (627 aa)
rassf2Ras association domain family member 2a. (341 aa)
ENSHBUP00000012738Uncharacterized protein. (295 aa)
LOC102314648Zinc finger protein 207. (461 aa)
DCTN6Dynactin subunit 6. (205 aa)
ncapd2Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1141 aa)
LOC102301954Lysine (K)-specific demethylase 4B. (1067 aa)
cenpiCentromere protein I. (733 aa)
bub1bBUB1 mitotic checkpoint serine/threonine kinase Bb. (426 aa)
ercc4Excision repair cross-complementation group 4. (899 aa)
cenpnCentromere protein N. (348 aa)
LOC102304191Structural maintenance of chromosomes protein. (1245 aa)
ska2Spindle and kinetochore associated complex subunit 2. (224 aa)
LOC102303125Uncharacterized protein. (379 aa)
majinUncharacterized protein. (204 aa)
LOC102308912Chromobox homolog 3a (HP1 gamma homolog, Drosophila). (174 aa)
nsmce1NSE1 homolog, SMC5-SMC6 complex component. (264 aa)
LOC102299901PIN2 (TERF1) interacting telomerase inhibitor 1. (156 aa)
fbxo28F-box protein 28. (378 aa)
mis12MIS12 kinetochore complex component. (231 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (464 aa)
clasp2Cytoplasmic linker associated protein 2. (1208 aa)
ZNF207Zinc finger protein 207, b. (472 aa)
ENSHBUP00000016535Uncharacterized protein. (544 aa)
anapc16Anaphase promoting complex subunit 16. (108 aa)
cenpfCentromere protein F. (2259 aa)
hat1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (408 aa)
bub3BUB3 mitotic checkpoint protein. (326 aa)
LOC102304158Nbl1_Borealin_N domain-containing protein. (257 aa)
pold1DNA polymerase. (1129 aa)
ENSHBUP00000017345AT hook containing transcription factor 1. (1859 aa)
LOC102296327Translocated promoter region a, nuclear basket protein. (1747 aa)
LOC102295763Uncharacterized protein. (113 aa)
cenpkCentromere protein K. (262 aa)
rcc2Regulator of chromosome condensation 2. (494 aa)
LOC102296990Exportin 1 (CRM1 homolog, yeast) b. (1071 aa)
seh1lSEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (351 aa)
fam193aFamily with sequence similarity 193 member A. (1615 aa)
LOC102291534TERF1 (TRF1)-interacting nuclear factor 2. (579 aa)
ENSHBUP00000018665Uncharacterized protein. (196 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
spc24SPC24 component of NDC80 kinetochore complex. (199 aa)
sirt6Sirtuin 6. (351 aa)
ENSHBUP00000019957Zinc finger protein 618. (798 aa)
rassf4Ras association domain family member 4a. (331 aa)
smc5SMC_N domain-containing protein. (1078 aa)
mki67Marker of proliferation Ki-67. (1892 aa)
DYNLT3Dynein, light chain, Tctex-type 3. (115 aa)
LOC102299711Poly [ADP-ribose] polymerase. (1279 aa)
KIF18AKinesin family member 18A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (751 aa)
RAD21RAD21 cohesin complex component. (648 aa)
nuf2UF2 component of NDC80 kinetochore complex. (436 aa)
znf276Zinc finger protein 276. (431 aa)
clasp1Cytoplasmic linker associated protein 1a. (1430 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (365 aa)
cdca8Cell division cycle associated 8. (279 aa)
LOC102298446Uncharacterized protein. (273 aa)
nudcd2NudC domain containing 2. (157 aa)
brca2BRCA2 DNA repair associated. (3303 aa)
BAZ1ABromodomain adjacent to zinc finger domain 1A. (1147 aa)
ercc1Excision repair cross-complementation group 1. (352 aa)
cep131Centrosomal protein 131. (1114 aa)
chrac1Chromatin accessibility complex subunit 1. (192 aa)
xrcc5X-ray repair complementing defective repair in Chinese hamster cells 5. (739 aa)
ten1TEN1 subunit of CST complex. (130 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
ncapgNon-SMC condensin I complex, subunit G. (1020 aa)
smc1aStructural maintenance of chromosomes protein. (1231 aa)
LOC102295920NudE neurodevelopment protein 1-like 1a. (343 aa)
ENSHBUP00000023677Protection of telomeres 1 homolog. (528 aa)
ska1Spindle and kinetochore associated complex subunit 1. (245 aa)
CBX1Chromobox homolog 1b (HP1 beta homolog Drosophila). (200 aa)
nbnNibrin. (779 aa)
LOC102301011Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (325 aa)
phf11PHD-type domain-containing protein. (274 aa)
cenptCENP-T_C domain-containing protein. (899 aa)
ENSHBUP00000024905Uncharacterized protein. (433 aa)
LOC102291667Aurora kinase B; Belongs to the protein kinase superfamily. (305 aa)
nup133Nucleoporin 133. (1135 aa)
xpo1Exportin 1 (CRM1 homolog, yeast) a. (1066 aa)
LOC102291296Selenoprotein H. (120 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
spo11SPO11 initiator of meiotic double stranded breaks. (390 aa)
LOC102302286Lysine (K)-specific demethylase 4A, genome duplicate b. (1176 aa)
spout1SPOUT domain containing methyltransferase 1. (379 aa)
znf330Zinc finger protein 330. (317 aa)
ndc80NDC80 kinetochore complex component. (639 aa)
LOC102311631Si:dkey-6i22.5. (226 aa)
nsmce4aNon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (349 aa)
nup43Nucleoporin 43. (372 aa)
ENSHBUP00000027738Uncharacterized protein. (482 aa)
LOC102300936DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1453 aa)
LOC102290810Uncharacterized protein. (1433 aa)
wrap53WD repeat containing, antisense to TP53. (544 aa)
mtbpMDM2 binding protein. (869 aa)
lrwd1Leucine-rich repeats and WD repeat domain containing 1. (743 aa)
cenphCENP-H domain-containing protein. (268 aa)
LOC102297012CCAAT enhancer binding protein beta. (292 aa)
nsmce2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
fmr1Fragile X mental retardation 1. (600 aa)
kdm4aLysine (K)-specific demethylase 4A, genome duplicate a. (1062 aa)
suv39h1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (411 aa)
oip5Mis18 domain-containing protein. (179 aa)
rad51dRAD51 paralog D. (333 aa)
ENSHBUP00000029795Uncharacterized protein. (382 aa)
ncapd3Non-SMC condensin II complex, subunit D3. (1397 aa)
ENSHBUP00000029831PHD-type domain-containing protein. (243 aa)
dctn3Dynactin 3 (p22). (187 aa)
ttkTtk protein kinase. (1006 aa)
cenpwUncharacterized protein. (75 aa)
dhx36DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1063 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1628 aa)
dctn5Dynactin 5. (182 aa)
smc3Structural maintenance of chromosomes protein. (1217 aa)
nek2NIMA-related kinase 2. (413 aa)
rangap1RAN GTPase activating protein 1a. (552 aa)
cdt1Chromatin licensing and DNA replication factor 1. (607 aa)
mad1l1Mitotic arrest deficient 1 like 1. (672 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (627 aa)
ENSHBUP00000032172Uncharacterized protein. (108 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (695 aa)
CBX1-2Uncharacterized protein. (213 aa)
ENSHBUP00000032296Uncharacterized protein. (134 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1084 aa)
incenpUncharacterized protein. (837 aa)
recql4RecQ helicase-like 4. (1577 aa)
zw10Zw10 kinetochore protein. (766 aa)
LOC102311321HTH myb-type domain-containing protein. (740 aa)
terf2HTH myb-type domain-containing protein. (561 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (898 aa)
NDE1NudE neurodevelopment protein 1. (315 aa)
smg6SMG6 nonsense mediated mRNA decay factor. (1641 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1507 aa)
cenpvCentromere protein V. (128 aa)
LOC102290331Baculoviral IAP repeat containing 5a. (142 aa)
dclre1bDNA cross-link repair 1B. (586 aa)
orc2Origin recognition complex, subunit 2. (604 aa)
gpatch11G patch domain containing 11. (194 aa)
rec8REC8 meiotic recombination protein b. (580 aa)
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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