(57 nodes) Regulation of DNA biosynthetic process network (Haplochromis burtoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gins3	GINS complex subunit 3. (211 aa)
	pnkp	Polynucleotide kinase 3'-phosphatase. (602 aa)
	naf1	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (302 aa)
	cct2	Chaperonin containing TCP1, subunit 2 (beta). (535 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (453 aa)
	nat10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1035 aa)
	fbxo4	F-box protein 4. (396 aa)
	pdgfb	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (549 aa)
	ENSHBUP00000005048	TAN domain-containing protein. (177 aa)
	ENSHBUP00000005062	Uncharacterized protein. (143 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	ccdc174	Coiled-coil domain containing 174. (544 aa)
	map3k4	Mitogen-activated protein kinase kinase kinase 4. (1486 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	grem1	Gremlin 1a, DAN family BMP antagonist. (179 aa)
	gins4	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa)
	parp3	Poly [ADP-ribose] polymerase. (559 aa)
	cct3	T-complex protein 1 subunit gamma. (540 aa)
	rfc2	Replication factor C (activator 1) 2. (356 aa)
	men1	Multiple endocrine neoplasia I. (542 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3139 aa)
	ing4	Inhibitor of growth protein. (249 aa)
	ENSHBUP00000014429	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (525 aa)
	ENSHBUP00000014942	Inhibitor of growth family, member 5a. (150 aa)
	LOC102299901	PIN2 (TERF1) interacting telomerase inhibitor 1. (156 aa)
	nvl	Nuclear VCP like. (859 aa)
	ENSHBUP00000016535	Uncharacterized protein. (544 aa)
	LOC102291534	TERF1 (TRF1)-interacting nuclear factor 2. (579 aa)
	jade2	Jade family PHD finger 2. (930 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1067 aa)
	LOC102296050	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1199 aa)
	LOC102310023	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (515 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	polg2	Polymerase (DNA directed), gamma 2, accessory subunit. (455 aa)
	xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5. (739 aa)
	mapkapk5	MAPK activated protein kinase 5. (471 aa)
	ten1	TEN1 subunit of CST complex. (130 aa)
	ENSHBUP00000023677	Protection of telomeres 1 homolog. (528 aa)
	dcp2	Decapping mRNA 2. (391 aa)
	wrap53	WD repeat containing, antisense to TP53. (544 aa)
	dkc1	Dyskeratosis congenita 1, dyskerin. (500 aa)
	ENSHBUP00000028701	Uncharacterized protein. (70 aa)
	LOC102301026	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (573 aa)
	chtf8	CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (136 aa)
	nox4	FAD-binding FR-type domain-containing protein. (497 aa)
	gfer	Sulfhydryl oxidase. (197 aa)
	gnl3l	Guanine nucleotide binding protein-like 3 (nucleolar)-like. (566 aa)
	rgcc	Regulator of cell cycle. (128 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (460 aa)
	gins2	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (175 aa)
	nek2	NIMA-related kinase 2. (413 aa)
	parp4	Poly [ADP-ribose] polymerase. (1384 aa)
	chtf18	AAA domain-containing protein. (922 aa)
	LOC102311321	HTH myb-type domain-containing protein. (740 aa)
	terf2	HTH myb-type domain-containing protein. (561 aa)
	exosc10	Exosome component 10. (862 aa)
	cct5	Chaperonin containing TCP1, subunit 5 (epsilon). (541 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000005048	ENSHBUP00000005062	ENSHBUP00000005048	ENSHBUP00000005062	TAN domain-containing protein.	Uncharacterized protein.	0.923
ENSHBUP00000005048	ENSHBUP00000014429	ENSHBUP00000005048	ENSHBUP00000014429	TAN domain-containing protein.	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.	0.479
ENSHBUP00000005048	LOC102291534	ENSHBUP00000005048	ENSHBUP00000018248	TAN domain-containing protein.	TERF1 (TRF1)-interacting nuclear factor 2.	0.441
ENSHBUP00000005048	LOC102296050	ENSHBUP00000005048	ENSHBUP00000020007	TAN domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.437
ENSHBUP00000005048	LOC102301026	ENSHBUP00000005048	ENSHBUP00000028714	TAN domain-containing protein.	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.479
ENSHBUP00000005048	atr	ENSHBUP00000005048	ENSHBUP00000012697	TAN domain-containing protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.994
ENSHBUP00000005048	bmpr2	ENSHBUP00000005048	ENSHBUP00000019540	TAN domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.437
ENSHBUP00000005048	chek1	ENSHBUP00000005048	ENSHBUP00000030727	TAN domain-containing protein.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.950
ENSHBUP00000005048	rfc2	ENSHBUP00000005048	ENSHBUP00000012409	TAN domain-containing protein.	Replication factor C (activator 1) 2.	0.851
ENSHBUP00000005048	rfc3	ENSHBUP00000005048	ENSHBUP00000005084	TAN domain-containing protein.	Replication factor C (activator 1) 3.	0.846
ENSHBUP00000005048	rfc4	ENSHBUP00000005048	ENSHBUP00000022363	TAN domain-containing protein.	Replication factor C (activator 1) 4.	0.854
ENSHBUP00000005048	rfc5	ENSHBUP00000005048	ENSHBUP00000009180	TAN domain-containing protein.	Replication factor C (activator 1) 5.	0.844
ENSHBUP00000005048	xrcc5	ENSHBUP00000005048	ENSHBUP00000022579	TAN domain-containing protein.	X-ray repair complementing defective repair in Chinese hamster cells 5.	0.923
ENSHBUP00000005062	ENSHBUP00000005048	ENSHBUP00000005062	ENSHBUP00000005048	Uncharacterized protein.	TAN domain-containing protein.	0.923
ENSHBUP00000005062	ENSHBUP00000014429	ENSHBUP00000005062	ENSHBUP00000014429	Uncharacterized protein.	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.	0.479
ENSHBUP00000005062	LOC102291534	ENSHBUP00000005062	ENSHBUP00000018248	Uncharacterized protein.	TERF1 (TRF1)-interacting nuclear factor 2.	0.441
ENSHBUP00000005062	LOC102296050	ENSHBUP00000005062	ENSHBUP00000020007	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.437
ENSHBUP00000005062	LOC102301026	ENSHBUP00000005062	ENSHBUP00000028714	Uncharacterized protein.	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.479
ENSHBUP00000005062	atr	ENSHBUP00000005062	ENSHBUP00000012697	Uncharacterized protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.993
ENSHBUP00000005062	bmpr2	ENSHBUP00000005062	ENSHBUP00000019540	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.437