(100 nodes) Regulation of double-strand break repair network (Haplochromis burtoni)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	kmt5b	Lysine methyltransferase 5B. (910 aa)
	ENSHBUP00000002709	Uncharacterized protein. (138 aa)
	ENSHBUP00000003488	Uncharacterized protein. (79 aa)
	ENSHBUP00000004588	Uncharacterized protein. (187 aa)
	yeats4	YEATS domain containing 4. (226 aa)
	LOC102290288	Uncharacterized protein. (237 aa)
	ENSHBUP00000005202	Uncharacterized protein. (179 aa)
	rif1	Replication timing regulatory factor 1. (2354 aa)
	LOC102292484	RING-type domain-containing protein. (685 aa)
	ENSHBUP00000006466	Uncharacterized protein. (222 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (827 aa)
	parpbp	PARP1 binding protein. (587 aa)
	ENSHBUP00000007412	LEDGF domain-containing protein. (239 aa)
	ENSHBUP00000007464	PWWP domain-containing protein. (110 aa)
	ENSHBUP00000007488	Fumarate hydratase. (488 aa)
	shld2	Si:ch211-134m17.9. (753 aa)
	LOC102312342	SAP domain-containing protein. (374 aa)
	ENSHBUP00000007849	Uncharacterized protein. (118 aa)
	ENSHBUP00000007880	Pogo transposable element derived with ZNF domain b. (1907 aa)
	LOC102304128	SET domain-containing protein. (2044 aa)
	terf2ip	Uncharacterized protein. (685 aa)
	otub1	Ubiquitin thioesterase. (279 aa)
	ENSHBUP00000008597	DDE_3 domain-containing protein. (138 aa)
	slf1	SMC5-SMC6 complex localization factor 1. (885 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	ENSHBUP00000009214	Uncharacterized protein. (80 aa)
	ENSHBUP00000009374	HTH_Tnp_Tc3_2 domain-containing protein. (191 aa)
	LOC102300109	Si:dkey-3h3.3. (328 aa)
	FOXM1	Forkhead box M1. (637 aa)
	bcl7a	BAF chromatin remodeling complex subunit BCL7A. (199 aa)
	arid2	AT rich interactive domain 2 (ARID, RFX-like). (1702 aa)
	ENSHBUP00000011417	Uncharacterized protein. (74 aa)
	parp3	Poly [ADP-ribose] polymerase. (559 aa)
	ENSHBUP00000012003	DDE_3 domain-containing protein. (126 aa)
	ENSHBUP00000012104	Uncharacterized protein. (219 aa)
	trip12	Thyroid hormone receptor interactor 12. (2007 aa)
	LOC102309076	Enhancer of polycomb homolog. (787 aa)
	mrgbp	MRG/MORF4L binding protein. (220 aa)
	smchd1	Structural maintenance of chromosomes flexible hinge domain containing 1. (1672 aa)
	LOC102308466	Zgc:101810; Belongs to the actin family. (394 aa)
	LOC102291906	Mab-21 domain-containing protein. (516 aa)
	ENSHBUP00000016270	Paired domain-containing protein. (227 aa)
	ENSHBUP00000016596	Uncharacterized protein. (230 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3889 aa)
	ENSHBUP00000016909	Uncharacterized protein. (260 aa)
	sirt6	Sirtuin 6. (351 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2426 aa)
	ENSHBUP00000019558	DDE_3 domain-containing protein. (239 aa)
	rnf169	Ring finger protein 169. (585 aa)
	OTUB2	OTU deubiquitinase, ubiquitin aldehyde binding 2. (251 aa)
	ENSHBUP00000019917	Uncharacterized protein. (170 aa)
	pnkp	Polynucleotide kinase 3'-phosphatase. (602 aa)
	vps72	Vacuolar protein sorting 72 homolog a. (356 aa)
	helq	Helicase, POLQ like. (995 aa)
	hmga2	Uncharacterized protein. (114 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1710 aa)
	LOC102309713	SET domain and mariner transposase fusion gene. (167 aa)
	ENSHBUP00000001844	Uncharacterized protein. (214 aa)
	rmi2	RecQ mediated genome instability 2. (146 aa)
	LOC102303192	Spire-type actin nucleation factor 1a. (800 aa)
	LOC102295707	Uncharacterized protein. (1383 aa)
	ENSHBUP00000034973	RING-type domain-containing protein. (720 aa)
	fancb	FA complementation group B. (777 aa)
	trrap	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3770 aa)
	LOC102306769	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (817 aa)
	rtel1	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1137 aa)
	ENSHBUP00000032767	Uncharacterized protein. (112 aa)
	sirt7	Sirtuin 7. (405 aa)
	actr2	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
	MGMT	O-6-methylguanine-DNA methyltransferase. (216 aa)
	fbh1	F-box DNA helicase 1. (1076 aa)
	LOC102304552	Spire-type actin nucleation factor 1b. (868 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2605 aa)
	LOC102295288	RING-type domain-containing protein. (199 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (460 aa)
	ENSHBUP00000028885	Uncharacterized protein. (177 aa)
	wrap53	WD repeat containing, antisense to TP53. (544 aa)
	foxm1	Forkhead box M1. (630 aa)
	ENSHBUP00000027119	HTH_Tnp_Tc3_2 domain-containing protein. (170 aa)
	nsd2	Nuclear receptor binding SET domain protein 2. (1313 aa)
	LOC102313517	Enhancer of polycomb homolog. (837 aa)
	spidr	Scaffold protein involved in DNA repair. (935 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
	ENSHBUP00000025108	Uncharacterized protein. (198 aa)
	ogg1	8-oxoguanine DNA glycosylase. (415 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (507 aa)
	brd8	Si:ch211-59d17.3. (796 aa)
	radx	RPA1 related single stranded DNA binding protein. (843 aa)
	ENSHBUP00000023677	Protection of telomeres 1 homolog. (528 aa)
	timeless	Timeless circadian clock. (1249 aa)
	ENSHBUP00000022658	DDE_3 domain-containing protein. (150 aa)
	ENSHBUP00000022412	Uncharacterized protein. (1159 aa)
	LOC102309979	Bromodomain containing 8. (822 aa)
	mms19	MMS19 homolog, cytosolic iron-sulfur assembly component. (1031 aa)
	dtx3	Zgc:66440. (369 aa)
	dmap1	DNA methyltransferase 1 associated protein 1. (481 aa)
	spire2	Spire-type actin nucleation factor 2. (781 aa)
	wdr48	WD repeat domain 48b. (685 aa)
	ercc6	Excision repair cross-complementation group 6. (1439 aa)
	actl6a	Actin-like 6A; Belongs to the actin family. (432 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000002709	LOC102308466	ENSHBUP00000002709	ENSHBUP00000014762	Uncharacterized protein.	Zgc:101810; Belongs to the actin family.	0.460
ENSHBUP00000002709	actr2	ENSHBUP00000002709	ENSHBUP00000032225	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.460
ENSHBUP00000003488	LOC102309076	ENSHBUP00000003488	ENSHBUP00000012812	Uncharacterized protein.	Enhancer of polycomb homolog.	0.787
ENSHBUP00000003488	LOC102313517	ENSHBUP00000003488	ENSHBUP00000026331	Uncharacterized protein.	Enhancer of polycomb homolog.	0.787
ENSHBUP00000003488	actl6a	ENSHBUP00000003488	ENSHBUP00000020262	Uncharacterized protein.	Actin-like 6A; Belongs to the actin family.	0.739
ENSHBUP00000003488	brd8	ENSHBUP00000003488	ENSHBUP00000023739	Uncharacterized protein.	Si:ch211-59d17.3.	0.519
ENSHBUP00000003488	dmap1	ENSHBUP00000003488	ENSHBUP00000021096	Uncharacterized protein.	DNA methyltransferase 1 associated protein 1.	0.901
ENSHBUP00000003488	ercc6	ENSHBUP00000003488	ENSHBUP00000020553	Uncharacterized protein.	Excision repair cross-complementation group 6.	0.410
ENSHBUP00000003488	mrgbp	ENSHBUP00000003488	ENSHBUP00000012929	Uncharacterized protein.	MRG/MORF4L binding protein.	0.930
ENSHBUP00000003488	trrap	ENSHBUP00000003488	ENSHBUP00000033766	Uncharacterized protein.	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family.	0.884
ENSHBUP00000003488	vps72	ENSHBUP00000003488	ENSHBUP00000000746	Uncharacterized protein.	Vacuolar protein sorting 72 homolog a.	0.846
ENSHBUP00000003488	yeats4	ENSHBUP00000003488	ENSHBUP00000004626	Uncharacterized protein.	YEATS domain containing 4.	0.886
ENSHBUP00000004588	ENSHBUP00000006466	ENSHBUP00000004588	ENSHBUP00000006466	Uncharacterized protein.	Uncharacterized protein.	0.431
ENSHBUP00000004588	ENSHBUP00000016270	ENSHBUP00000004588	ENSHBUP00000016270	Uncharacterized protein.	Paired domain-containing protein.	0.472
ENSHBUP00000004588	ENSHBUP00000016596	ENSHBUP00000004588	ENSHBUP00000016596	Uncharacterized protein.	Uncharacterized protein.	0.518
ENSHBUP00000004588	ENSHBUP00000019917	ENSHBUP00000004588	ENSHBUP00000019917	Uncharacterized protein.	Uncharacterized protein.	0.465
ENSHBUP00000004588	ENSHBUP00000027119	ENSHBUP00000004588	ENSHBUP00000027119	Uncharacterized protein.	HTH_Tnp_Tc3_2 domain-containing protein.	0.445
ENSHBUP00000004588	LOC102308466	ENSHBUP00000004588	ENSHBUP00000014762	Uncharacterized protein.	Zgc:101810; Belongs to the actin family.	0.460
ENSHBUP00000004588	actr2	ENSHBUP00000004588	ENSHBUP00000032225	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.460
ENSHBUP00000005202	ENSHBUP00000006466	ENSHBUP00000005202	ENSHBUP00000006466	Uncharacterized protein.	Uncharacterized protein.	0.414