(50 nodes) Negative regulation of response to DNA damage stimulus network (Haplochromis burtoni)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC102303675	Clusterin; Belongs to the clusterin family. (463 aa)
	hmga2	Uncharacterized protein. (114 aa)
	thoc1	THO complex 1. (654 aa)
	tpt1	Tumor protein, translationally-controlled 1; Belongs to the TCTP family. (170 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1710 aa)
	ENSHBUP00000001844	Uncharacterized protein. (214 aa)
	rmi2	RecQ mediated genome instability 2. (146 aa)
	LOC102301397	Uncharacterized protein. (179 aa)
	LOC102290288	Uncharacterized protein. (237 aa)
	cdkn2d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
	rif1	Replication timing regulatory factor 1. (2354 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (827 aa)
	ppp1r10	Protein phosphatase 1, regulatory subunit 10. (807 aa)
	parpbp	PARP1 binding protein. (587 aa)
	LOC102304943	Atypical chemokine receptor 3a; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	fancb	FA complementation group B. (777 aa)
	LOC102310028	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (365 aa)
	LOC102306769	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (817 aa)
	LOC102288722	Uncharacterized protein. (958 aa)
	bcl2l12	Si:ch73-248e21.1. (356 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (627 aa)
	CLUL1	Clusterin; Belongs to the clusterin family. (465 aa)
	fbh1	F-box DNA helicase 1. (1076 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1383 aa)
	yju2	YJU2 splicing factor homolog. (340 aa)
	snai2	Snail family zinc finger 2. (260 aa)
	ogg1	8-oxoguanine DNA glycosylase. (415 aa)
	radx	RPA1 related single stranded DNA binding protein. (843 aa)
	marchf7	Membrane-associated ring finger (C3HC4) 7. (797 aa)
	psmd10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	ercc1	Excision repair cross-complementation group 1. (352 aa)
	LOC102291934	Uncharacterized protein. (181 aa)
	ercc6	Excision repair cross-complementation group 6. (1439 aa)
	nhlrc4	Tripartite motif containing 32. (693 aa)
	OTUB2	OTU deubiquitinase, ubiquitin aldehyde binding 2. (251 aa)
	rnf169	Ring finger protein 169. (585 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2426 aa)
	ddias	Uncharacterized protein. (786 aa)
	chek2	Checkpoint kinase 2. (521 aa)
	triap1	TP53 regulated inhibitor of apoptosis 1. (116 aa)
	LOC102291906	Mab-21 domain-containing protein. (516 aa)
	smchd1	Structural maintenance of chromosomes flexible hinge domain containing 1. (1672 aa)
	ercc4	Excision repair cross-complementation group 4. (899 aa)
	LOC102312405	ATPase family AAA domain containing 5a. (1808 aa)
	trip12	Thyroid hormone receptor interactor 12. (2007 aa)
	otub1	Ubiquitin thioesterase. (279 aa)
	shld2	Si:ch211-134m17.9. (753 aa)
	clu	Clusterin; Belongs to the clusterin family. (491 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (715 aa)
	tmem161a	Transmembrane protein 161A. (496 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102290288	shld2	ENSHBUP00000004829	ENSHBUP00000007744	Uncharacterized protein.	Si:ch211-134m17.9.	0.952
LOC102290288	tp53bp1	ENSHBUP00000004829	ENSHBUP00000001551	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.492
LOC102304943	LOC102310028	ENSHBUP00000035307	ENSHBUP00000033907	Atypical chemokine receptor 3a; Belongs to the G-protein coupled receptor 1 family.	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.811
LOC102306769	LOC102312405	ENSHBUP00000033380	ENSHBUP00000012971	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	ATPase family AAA domain containing 5a.	0.808
LOC102306769	chek2	ENSHBUP00000033380	ENSHBUP00000017690	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Checkpoint kinase 2.	0.778
LOC102306769	ercc1	ENSHBUP00000033380	ENSHBUP00000022312	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Excision repair cross-complementation group 1.	0.453
LOC102306769	ercc4	ENSHBUP00000033380	ENSHBUP00000014336	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Excision repair cross-complementation group 4.	0.919
LOC102306769	ercc6	ENSHBUP00000033380	ENSHBUP00000020553	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Excision repair cross-complementation group 6.	0.482
LOC102306769	fbh1	ENSHBUP00000033380	ENSHBUP00000031178	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	F-box DNA helicase 1.	0.988
LOC102306769	ogg1	ENSHBUP00000033380	ENSHBUP00000025049	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	8-oxoguanine DNA glycosylase.	0.599
LOC102306769	rmi2	ENSHBUP00000033380	ENSHBUP00000001981	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	RecQ mediated genome instability 2.	0.942
LOC102306769	sirt1	ENSHBUP00000033380	ENSHBUP00000009767	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Deacetylase sirtuin-type domain-containing protein.	0.521
LOC102306769	tp53bp1	ENSHBUP00000033380	ENSHBUP00000001551	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Tumor protein p53 binding protein, 1.	0.907
LOC102310028	LOC102304943	ENSHBUP00000033907	ENSHBUP00000035307	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Atypical chemokine receptor 3a; Belongs to the G-protein coupled receptor 1 family.	0.811
LOC102312405	LOC102306769	ENSHBUP00000012971	ENSHBUP00000033380	ATPase family AAA domain containing 5a.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.808
LOC102312405	chek2	ENSHBUP00000012971	ENSHBUP00000017690	ATPase family AAA domain containing 5a.	Checkpoint kinase 2.	0.653
LOC102312405	ercc4	ENSHBUP00000012971	ENSHBUP00000014336	ATPase family AAA domain containing 5a.	Excision repair cross-complementation group 4.	0.790
LOC102312405	fbh1	ENSHBUP00000012971	ENSHBUP00000031178	ATPase family AAA domain containing 5a.	F-box DNA helicase 1.	0.730
LOC102312405	parpbp	ENSHBUP00000012971	ENSHBUP00000007121	ATPase family AAA domain containing 5a.	PARP1 binding protein.	0.429
LOC102312405	rmi2	ENSHBUP00000012971	ENSHBUP00000001981	ATPase family AAA domain containing 5a.	RecQ mediated genome instability 2.	0.628