(17 nodes) Replisome network (Haplochromis burtoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cdc6	Cell division cycle 6 homolog (S. cerevisiae). (429 aa)
	rpa2	Replication protein A2. (293 aa)
	pold1	DNA polymerase. (1129 aa)
	dars2	Aspartyl-tRNA synthetase 2, mitochondrial. (659 aa)
	ENSHBUP00000015244	Uncharacterized protein. (201 aa)
	pold4	Si:dkey-28b4.7. (107 aa)
	ENSHBUP00000013644	Si:dkeyp-11e3.1. (198 aa)
	pola2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (481 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (444 aa)
	prim2	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (513 aa)
	LOC102313474	Uncharacterized protein. (197 aa)
	pola1	DNA polymerase. (1482 aa)
	LOC102298094	Zgc:136864. (96 aa)
	cdt1	Chromatin licensing and DNA replication factor 1. (607 aa)
	rpa3	Replication protein A3. (122 aa)
	prim1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000015244	LOC102313474	ENSHBUP00000015244	ENSHBUP00000034534	Uncharacterized protein.	Uncharacterized protein.	0.884
ENSHBUP00000015244	cdt1	ENSHBUP00000015244	ENSHBUP00000031760	Uncharacterized protein.	Chromatin licensing and DNA replication factor 1.	0.407
ENSHBUP00000015244	pola2	ENSHBUP00000015244	ENSHBUP00000010339	Uncharacterized protein.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.456
ENSHBUP00000015244	pold2	ENSHBUP00000015244	ENSHBUP00000009226	Uncharacterized protein.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.520
ENSHBUP00000015244	prim2	ENSHBUP00000015244	ENSHBUP00000006561	Uncharacterized protein.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.779
LOC102313474	ENSHBUP00000015244	ENSHBUP00000034534	ENSHBUP00000015244	Uncharacterized protein.	Uncharacterized protein.	0.884
LOC102313474	cdt1	ENSHBUP00000034534	ENSHBUP00000031760	Uncharacterized protein.	Chromatin licensing and DNA replication factor 1.	0.407
LOC102313474	pola2	ENSHBUP00000034534	ENSHBUP00000010339	Uncharacterized protein.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.456
LOC102313474	pold2	ENSHBUP00000034534	ENSHBUP00000009226	Uncharacterized protein.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.520
LOC102313474	prim2	ENSHBUP00000034534	ENSHBUP00000006561	Uncharacterized protein.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.779
cdc6	cdt1	ENSHBUP00000005263	ENSHBUP00000031760	Cell division cycle 6 homolog (S. cerevisiae).	Chromatin licensing and DNA replication factor 1.	0.999
cdc6	pola1	ENSHBUP00000005263	ENSHBUP00000034226	Cell division cycle 6 homolog (S. cerevisiae).	DNA polymerase.	0.907
cdc6	pola2	ENSHBUP00000005263	ENSHBUP00000010339	Cell division cycle 6 homolog (S. cerevisiae).	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.940
cdc6	pold1	ENSHBUP00000005263	ENSHBUP00000017205	Cell division cycle 6 homolog (S. cerevisiae).	DNA polymerase.	0.905
cdc6	prim1	ENSHBUP00000005263	ENSHBUP00000028250	Cell division cycle 6 homolog (S. cerevisiae).	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.939
cdc6	prim2	ENSHBUP00000005263	ENSHBUP00000006561	Cell division cycle 6 homolog (S. cerevisiae).	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.903
cdc6	rpa2	ENSHBUP00000005263	ENSHBUP00000026512	Cell division cycle 6 homolog (S. cerevisiae).	Replication protein A2.	0.694
cdc6	rpa3	ENSHBUP00000005263	ENSHBUP00000030218	Cell division cycle 6 homolog (S. cerevisiae).	Replication protein A3.	0.711
cdt1	ENSHBUP00000015244	ENSHBUP00000031760	ENSHBUP00000015244	Chromatin licensing and DNA replication factor 1.	Uncharacterized protein.	0.407
cdt1	LOC102313474	ENSHBUP00000031760	ENSHBUP00000034534	Chromatin licensing and DNA replication factor 1.	Uncharacterized protein.	0.407