(15 nodes) DHS-like NAD/FAD-binding domain superfamily network (Haplochromis burtoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sirt6	Sirtuin 6. (351 aa)
	sirt7	Sirtuin 7. (405 aa)
	dhps	Deoxyhypusine synthase. (376 aa)
	hacl1	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (568 aa)
	LOC102300464	Nicotinamide nucleotide transhydrogenase. (1085 aa)
	etfa	Electron transfer flavoprotein subunit alpha. (343 aa)
	LOC102301083	Nicotinamide nucleotide transhydrogenase 2. (1071 aa)
	LOC102308358	Sirtuin 3. (279 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (715 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (311 aa)
	LOC102307567	Si:dkey-103i16.6. (443 aa)
	LOC102291891	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (306 aa)
	ilvbl	IlvB (bacterial acetolactate synthase)-like; Belongs to the TPP enzyme family. (625 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (382 aa)
	sirt5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (301 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102291891	LOC102300464	ENSHBUP00000004355	ENSHBUP00000013832	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Nicotinamide nucleotide transhydrogenase.	0.851
LOC102291891	LOC102301083	ENSHBUP00000004355	ENSHBUP00000010816	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Nicotinamide nucleotide transhydrogenase 2.	0.851
LOC102291891	LOC102307567	ENSHBUP00000004355	ENSHBUP00000007495	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Si:dkey-103i16.6.	0.890
LOC102291891	LOC102308358	ENSHBUP00000004355	ENSHBUP00000017191	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Sirtuin 3.	0.888
LOC102291891	sirt1	ENSHBUP00000004355	ENSHBUP00000009767	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Deacetylase sirtuin-type domain-containing protein.	0.865
LOC102291891	sirt2	ENSHBUP00000004355	ENSHBUP00000021220	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.930
LOC102291891	sirt4	ENSHBUP00000004355	ENSHBUP00000009107	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.907
LOC102291891	sirt6	ENSHBUP00000004355	ENSHBUP00000019117	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Sirtuin 6.	0.931
LOC102291891	sirt7	ENSHBUP00000004355	ENSHBUP00000032612	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Sirtuin 7.	0.936
LOC102300464	LOC102291891	ENSHBUP00000013832	ENSHBUP00000004355	Nicotinamide nucleotide transhydrogenase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.851
LOC102300464	LOC102301083	ENSHBUP00000013832	ENSHBUP00000010816	Nicotinamide nucleotide transhydrogenase.	Nicotinamide nucleotide transhydrogenase 2.	0.851
LOC102300464	LOC102307567	ENSHBUP00000013832	ENSHBUP00000007495	Nicotinamide nucleotide transhydrogenase.	Si:dkey-103i16.6.	0.852
LOC102300464	LOC102308358	ENSHBUP00000013832	ENSHBUP00000017191	Nicotinamide nucleotide transhydrogenase.	Sirtuin 3.	0.852
LOC102300464	sirt1	ENSHBUP00000013832	ENSHBUP00000009767	Nicotinamide nucleotide transhydrogenase.	Deacetylase sirtuin-type domain-containing protein.	0.852
LOC102300464	sirt2	ENSHBUP00000013832	ENSHBUP00000021220	Nicotinamide nucleotide transhydrogenase.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.851
LOC102300464	sirt4	ENSHBUP00000013832	ENSHBUP00000009107	Nicotinamide nucleotide transhydrogenase.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.851
LOC102300464	sirt5	ENSHBUP00000013832	ENSHBUP00000020721	Nicotinamide nucleotide transhydrogenase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.851
LOC102300464	sirt6	ENSHBUP00000013832	ENSHBUP00000019117	Nicotinamide nucleotide transhydrogenase.	Sirtuin 6.	0.851
LOC102300464	sirt7	ENSHBUP00000013832	ENSHBUP00000032612	Nicotinamide nucleotide transhydrogenase.	Sirtuin 7.	0.853
LOC102301083	LOC102291891	ENSHBUP00000010816	ENSHBUP00000004355	Nicotinamide nucleotide transhydrogenase 2.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.851