38 items (Haplochromis burtoni) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	wdr48	WD repeat domain 48b. (685 aa)
	ubb	Ubiquitin-like domain-containing protein. (54 aa)
	meiob	Methionine sulfoxide reductase B1b. (464 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (828 aa)
	pold1	DNA polymerase. (1129 aa)
	dtl	Denticleless E3 ubiquitin protein ligase homolog (Drosophila). (661 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (865 aa)
	pold4	Si:dkey-28b4.7. (107 aa)
	rfc2	Replication factor C (activator 1) 2. (356 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (481 aa)
	LOC102312405	ATPase family AAA domain containing 5a. (1808 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
	LOC102314666	Ubiquitin-like domain-containing protein. (131 aa)
	rpa3	Replication protein A3. (122 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rad18	RAD18 E3 ubiquitin protein ligase. (453 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	rpa2	Replication protein A2. (293 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
	LOC102297270	SCY domain-containing protein. (125 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (532 aa)
	ddb1	Damage-specific DNA binding protein 1. (1140 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (444 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	ENSHBUP00000004241	Polymerase (DNA directed), epsilon 3 (p17 subunit). (147 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	rfc1	BRCT domain-containing protein. (471 aa)
	ENSHBUP00000001804	RFC1 domain-containing protein. (135 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (692 aa)
	LOC102288768	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2016 aa)
	LOC102313827	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000001804	ENSHBUP00000004241	ENSHBUP00000001804	ENSHBUP00000004241	RFC1 domain-containing protein.	Polymerase (DNA directed), epsilon 3 (p17 subunit).	0.833
ENSHBUP00000001804	LOC102297270	ENSHBUP00000001804	ENSHBUP00000008064	RFC1 domain-containing protein.	SCY domain-containing protein.	0.700
ENSHBUP00000001804	LOC102312405	ENSHBUP00000001804	ENSHBUP00000012971	RFC1 domain-containing protein.	ATPase family AAA domain containing 5a.	0.547
ENSHBUP00000001804	LOC102314666	ENSHBUP00000001804	ENSHBUP00000031002	RFC1 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.719
ENSHBUP00000001804	RPA1	ENSHBUP00000001804	ENSHBUP00000007812	RFC1 domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.886
ENSHBUP00000001804	cul4a	ENSHBUP00000001804	ENSHBUP00000000595	RFC1 domain-containing protein.	Cullin 4A; Belongs to the cullin family.	0.648
ENSHBUP00000001804	cul4b	ENSHBUP00000001804	ENSHBUP00000015278	RFC1 domain-containing protein.	Cullin 4B; Belongs to the cullin family.	0.648
ENSHBUP00000001804	ddb1	ENSHBUP00000001804	ENSHBUP00000007296	RFC1 domain-containing protein.	Damage-specific DNA binding protein 1.	0.664
ENSHBUP00000001804	dtl	ENSHBUP00000001804	ENSHBUP00000015716	RFC1 domain-containing protein.	Denticleless E3 ubiquitin protein ligase homolog (Drosophila).	0.819
ENSHBUP00000001804	meiob	ENSHBUP00000001804	ENSHBUP00000018421	RFC1 domain-containing protein.	Methionine sulfoxide reductase B1b.	0.833
ENSHBUP00000001804	pcna	ENSHBUP00000001804	ENSHBUP00000029821	RFC1 domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.984
ENSHBUP00000001804	pold1	ENSHBUP00000001804	ENSHBUP00000017205	RFC1 domain-containing protein.	DNA polymerase.	0.857
ENSHBUP00000001804	pold2	ENSHBUP00000001804	ENSHBUP00000009226	RFC1 domain-containing protein.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.751
ENSHBUP00000001804	pold3	ENSHBUP00000001804	ENSHBUP00000007064	RFC1 domain-containing protein.	Polymerase (DNA-directed), delta 3, accessory subunit.	0.574
ENSHBUP00000001804	pold4	ENSHBUP00000001804	ENSHBUP00000014324	RFC1 domain-containing protein.	Si:dkey-28b4.7.	0.574
ENSHBUP00000001804	pole	ENSHBUP00000001804	ENSHBUP00000025661	RFC1 domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.885
ENSHBUP00000001804	pole2	ENSHBUP00000001804	ENSHBUP00000007426	RFC1 domain-containing protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.836
ENSHBUP00000001804	pole4	ENSHBUP00000001804	ENSHBUP00000008082	RFC1 domain-containing protein.	Polymerase (DNA-directed), epsilon 4, accessory subunit.	0.739
ENSHBUP00000001804	rad18	ENSHBUP00000001804	ENSHBUP00000029081	RFC1 domain-containing protein.	RAD18 E3 ubiquitin protein ligase.	0.800
ENSHBUP00000001804	rbx1	ENSHBUP00000001804	ENSHBUP00000015583	RFC1 domain-containing protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.657