STRINGSTRING
LOC102304742 LOC102304742 LOC102297192 LOC102297192 grb2 grb2 ENSHBUP00000034273 ENSHBUP00000034273 LOC102311290 LOC102311290 fgf8 fgf8 fgfr4 fgfr4 LOC102292008 LOC102292008 LOC102304410 LOC102304410 fgf20 fgf20 pde3b pde3b LOC102304610 LOC102304610 LOC102311744 LOC102311744 LOC102289294 LOC102289294 LOC102291222 LOC102291222 LOC102289393 LOC102289393 FGF6-2 FGF6-2 LOC102291452 LOC102291452 fgf22 fgf22 gab1 gab1 fgf18 fgf18 klb klb LOC102312030 LOC102312030 LOC102314346 LOC102314346 fgf5 fgf5 LOC102305144 LOC102305144 pdpk1 pdpk1 LOC102300439 LOC102300439 LOC102297386 LOC102297386 pik3cb pik3cb ENSHBUP00000019390 ENSHBUP00000019390 fgf2 fgf2 LOC102310436 LOC102310436 LOC102291075 LOC102291075 LOC102307281 LOC102307281 FGF13 FGF13 fgf19 fgf19 fgf4 fgf4 LOC102302326 LOC102302326 fgf3 fgf3 LOC102300437 LOC102300437 FGF6 FGF6 lctl lctl fgf7 fgf7 fgf10 fgf10 ENSHBUP00000009952 ENSHBUP00000009952 fgfr2 fgfr2 fgf23 fgf23 ENSHBUP00000005111 ENSHBUP00000005111 kl kl ENSHBUP00000003882 ENSHBUP00000003882 ENSHBUP00000003732 ENSHBUP00000003732 pik3ca pik3ca LOC102303940 LOC102303940 LOC102296557 LOC102296557 LOC106633073 LOC106633073 fgf16 fgf16 gab2 gab2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102304742Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
LOC102297192Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
grb2Growth factor receptor-bound protein 2b. (217 aa)
ENSHBUP00000034273Zgc:158659; Belongs to the PI3/PI4-kinase family. (485 aa)
LOC102311290Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (594 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
fgfr4Fibroblast growth factor receptor 4. (945 aa)
LOC102292008Uncharacterized protein. (458 aa)
LOC102304410Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
pde3bPhosphodiesterase. (1099 aa)
LOC102304610Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
LOC102311744Tribbles pseudokinase 3. (353 aa)
LOC102289294Fibroblast growth factor receptor. (836 aa)
LOC102291222Insulin receptor substrate 2b. (1160 aa)
LOC102289393PH domain-containing protein. (543 aa)
FGF6-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC102291452Fibroblast growth factor receptor. (818 aa)
fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
gab1GRB2-associated binding protein 1. (746 aa)
fgf18Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
klbKlotho beta. (1049 aa)
LOC102312030Fibroblast growth factor receptor substrate 2b. (525 aa)
LOC102314346Insulin receptor substrate 2a. (1086 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
LOC102305144Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (666 aa)
pdpk13-phosphoinositide dependent protein kinase 1b. (565 aa)
LOC102300439Thioesterase superfamily member 4. (249 aa)
LOC102297386Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
ENSHBUP00000019390Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (284 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
LOC102310436Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
LOC102291075Fibroblast growth factor receptor. (709 aa)
LOC102307281Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
LOC102302326Lactase-like a; Belongs to the glycosyl hydrolase 1 family. (574 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
LOC102300437Uncharacterized protein. (248 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
lctlLactase-like b; Belongs to the glycosyl hydrolase 1 family. (585 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
ENSHBUP00000009952PH domain-containing protein. (146 aa)
fgfr2Fibroblast growth factor receptor. (835 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (255 aa)
ENSHBUP00000005111Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
klKlotho. (978 aa)
ENSHBUP00000003882Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (441 aa)
ENSHBUP00000003732Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (373 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102303940Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
LOC102296557Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
LOC106633073Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
gab2GRB2-associated binding protein 2. (654 aa)
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.