STRINGSTRING
fgf7 fgf7 LOC102292440 LOC102292440 LOC102304206 LOC102304206 LOC102300439 LOC102300439 ENSHBUP00000023832 ENSHBUP00000023832 LOC102305144 LOC102305144 kitlg kitlg fgf5 fgf5 LOC102314346 LOC102314346 mapk1 mapk1 lrrc40 lrrc40 LOC102306378 LOC102306378 LOC102312030 LOC102312030 LOC102313924 LOC102313924 klb klb LOC102313134 LOC102313134 met met fgf18 fgf18 pip4k2c pip4k2c gab1 gab1 fgf22 fgf22 egfr egfr LOC102291452 LOC102291452 FGF6-2 FGF6-2 LOC102289393 LOC102289393 LOC102288968 LOC102288968 LOC102289283 LOC102289283 LOC102291222 LOC102291222 LOC102298669 LOC102298669 LOC102289294 LOC102289294 LOC102311744 LOC102311744 LOC102294412 LOC102294412 LOC102304610 LOC102304610 pik3r2 pik3r2 LOC102293792 LOC102293792 ins ins pdgfra pdgfra irak4 irak4 myd88 myd88 strn3 strn3 ppp2r5b ppp2r5b fgf20 fgf20 LOC102304410 LOC102304410 LOC102301386 LOC102301386 flt3 flt3 LOC102296522 LOC102296522 strn4 strn4 LOC102292008 LOC102292008 fgfr4 fgfr4 fgf8 fgf8 LOC102297038 LOC102297038 PIP5K1C PIP5K1C LOC102311290 LOC102311290 ENSHBUP00000034273 ENSHBUP00000034273 grb2 grb2 fyn fyn ppp2r5e ppp2r5e LOC102297192 LOC102297192 pip4k2a pip4k2a LOC102301767 LOC102301767 LOC102301919 LOC102301919 egf egf PIP4K2B PIP4K2B gab2 gab2 nrg2 nrg2 ENSHBUP00000000495 ENSHBUP00000000495 fgf16 fgf16 LOC106633073 LOC106633073 LOC102296557 LOC102296557 LOC102313704 LOC102313704 LOC102290684 LOC102290684 cd276 cd276 ENSHBUP00000002129 ENSHBUP00000002129 LOC102309130 LOC102309130 SRC SRC LOC102303940 LOC102303940 fam102b fam102b LOC102292733 LOC102292733 ENSHBUP00000003075 ENSHBUP00000003075 pik3ca pik3ca LOC102301665 LOC102301665 LOC102308504 LOC102308504 ENSHBUP00000003732 ENSHBUP00000003732 ENSHBUP00000003882 ENSHBUP00000003882 LOC102306195 LOC102306195 ppp4r4 ppp4r4 LOC102291376 LOC102291376 btc btc pdgfb pdgfb ppp2cb ppp2cb LOC102294942 LOC102294942 erbb2 erbb2 kl kl ENSHBUP00000005111 ENSHBUP00000005111 fnbp4 fnbp4 pik3r1 pik3r1 LOC102307142 LOC102307142 LOC102301101 LOC102301101 LOC102314301 LOC102314301 LOC102296758 LOC102296758 pdgfa pdgfa ppp2r5d ppp2r5d traf6 traf6 esr1 esr1 erbb3 erbb3 ENSHBUP00000007276 ENSHBUP00000007276 hgf hgf pip5k1c pip5k1c ENSHBUP00000008836 ENSHBUP00000008836 fgf23 fgf23 LOC102303337 LOC102303337 fgfr2 fgfr2 LOC102307534 LOC102307534 LOC102291943 LOC102291943 ENSHBUP00000009952 ENSHBUP00000009952 LOC102289622 LOC102289622 pip5k1b pip5k1b pik3ap1 pik3ap1 fgf10 fgf10 LOC102296173 LOC102296173 lctl lctl FGF6 FGF6 LOC102300437 LOC102300437 PHLPP2 PHLPP2 pip5kl1 pip5kl1 LOC102312174 LOC102312174 fgf3 fgf3 LOC102302326 LOC102302326 fgf4 fgf4 fgf19 fgf19 LOC102292514 LOC102292514 LOC102296098 LOC102296098 LOC102303266 LOC102303266 fndc3b fndc3b FGF13 FGF13 nrg4 nrg4 kit kit LOC102302082 LOC102302082 LOC102307281 LOC102307281 akt1 akt1 ENSHBUP00000014471 ENSHBUP00000014471 INSC INSC ppp2r5a ppp2r5a il1rap il1rap BANK1 BANK1 LOC102298841 LOC102298841 LOC102291075 LOC102291075 LOC102310436 LOC102310436 lck lck fgf2 fgf2 ENSHBUP00000018527 ENSHBUP00000018527 LOC102302192 LOC102302192 irak1 irak1 pten pten pik3cd pik3cd PIP5K1A PIP5K1A ppp2ca ppp2ca ENSHBUP00000019390 ENSHBUP00000019390 ENSHBUP00000019721 ENSHBUP00000019721 ENSHBUP00000019737 ENSHBUP00000019737 LOC102304742 LOC102304742 LOC102305789 LOC102305789 LOC102310023 LOC102310023 LOC102310296 LOC102310296 LOC102292547 LOC102292547 pik3cb pik3cb relch relch PPP2R5C PPP2R5C fndc3a fndc3a ENSHBUP00000022085 ENSHBUP00000022085 pdgfrb pdgfrb LOC102304321 LOC102304321 LOC102312966 LOC102312966 ppp4r1 ppp4r1 LOC102297386 LOC102297386
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
LOC102292440Receptor protein-tyrosine kinase. (1405 aa)
LOC102304206Erb-b2 receptor tyrosine kinase 3b. (1464 aa)
LOC102300439Thioesterase superfamily member 4. (249 aa)
ENSHBUP00000023832MORN repeat containing 2. (131 aa)
LOC102305144Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (666 aa)
kitlgKit ligand a. (265 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
LOC102314346Insulin receptor substrate 2a. (1086 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
lrrc40Leucine rich repeat containing 40. (597 aa)
LOC102306378Uncharacterized protein. (216 aa)
LOC102312030Fibroblast growth factor receptor substrate 2b. (525 aa)
LOC102313924Neuregulin 1. (626 aa)
klbKlotho beta. (1049 aa)
LOC102313134Phosphatidylinositol-4-phosphate 5-kinase, type I, beta b. (530 aa)
metMET proto-oncogene, receptor tyrosine kinase. (1420 aa)
fgf18Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
pip4k2cPhosphatidylinositol-5-phosphate 4-kinase, type II, gamma a. (434 aa)
gab1GRB2-associated binding protein 1. (746 aa)
fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
egfrReceptor protein-tyrosine kinase. (1120 aa)
LOC102291452Fibroblast growth factor receptor. (818 aa)
FGF6-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC102289393PH domain-containing protein. (543 aa)
LOC102288968Epithelial mitogen homolog (mouse). (164 aa)
LOC102289283EGF-like domain-containing protein. (154 aa)
LOC102291222Insulin receptor substrate 2b. (1160 aa)
LOC102298669Receptor protein-tyrosine kinase. (1116 aa)
LOC102289294Fibroblast growth factor receptor. (836 aa)
LOC102311744Tribbles pseudokinase 3. (353 aa)
LOC102294412Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (955 aa)
LOC102304610Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
pik3r2Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (735 aa)
LOC102293792Uncharacterized protein. (498 aa)
insInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (113 aa)
pdgfraPlatelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1468 aa)
irak4Interleukin-1 receptor-associated kinase 4. (462 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (288 aa)
strn3Striatin, calmodulin binding protein 3. (718 aa)
ppp2r5bSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (522 aa)
fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
LOC102304410Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102301386Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
flt3Fms-related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (913 aa)
LOC102296522Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (464 aa)
strn4Striatin, calmodulin binding protein 4. (773 aa)
LOC102292008Uncharacterized protein. (458 aa)
fgfr4Fibroblast growth factor receptor 4. (945 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
LOC102297038Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (445 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (794 aa)
LOC102311290Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (594 aa)
ENSHBUP00000034273Zgc:158659; Belongs to the PI3/PI4-kinase family. (485 aa)
grb2Growth factor receptor-bound protein 2b. (217 aa)
fynTyrosine-protein kinase. (537 aa)
ppp2r5eSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (478 aa)
LOC102297192Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
pip4k2aPhosphatidylinositol-5-phosphate 4-kinase, type II, alpha a. (442 aa)
LOC102301767PPM-type phosphatase domain-containing protein. (1709 aa)
LOC102301919Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma b. (411 aa)
egfEpidermal growth factor. (1159 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (412 aa)
gab2GRB2-associated binding protein 2. (654 aa)
nrg2Neuregulin 2b. (712 aa)
ENSHBUP00000000495Ras homolog gene family, member Gd. (128 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC106633073Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC102296557Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
LOC102313704Striatin, calmodulin binding protein. (777 aa)
LOC102290684Serine/threonine-protein phosphatase. (309 aa)
cd276CD276 molecule. (306 aa)
ENSHBUP00000002129Uncharacterized protein. (194 aa)
LOC102309130Uncharacterized protein. (564 aa)
SRCTyrosine-protein kinase. (550 aa)
LOC102303940Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
fam102bFamily with sequence similarity 102 member Bb. (303 aa)
LOC102292733Neuregulin 2a. (681 aa)
ENSHBUP00000003075Uncharacterized protein. (98 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102301665Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b. (610 aa)
LOC102308504Tyrosine-protein kinase receptor. (1375 aa)
ENSHBUP00000003732Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (373 aa)
ENSHBUP00000003882Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (441 aa)
LOC102306195Neuregulin 3b. (657 aa)
ppp4r4Protein phosphatase 4, regulatory subunit 4. (935 aa)
LOC102291376PH domain and leucine rich repeat protein phosphatase 1. (1781 aa)
btcBetacellulin, epidermal growth factor family member. (172 aa)
pdgfbPlatelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (549 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
LOC102294942Uncharacterized protein. (588 aa)
erbb2Receptor protein-tyrosine kinase. (1309 aa)
klKlotho. (978 aa)
ENSHBUP00000005111Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
fnbp4Formin binding protein 4. (895 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (729 aa)
LOC102307142Tyrosine-protein kinase. (537 aa)
LOC102301101Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
LOC102314301Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (206 aa)
LOC102296758Tyrosine-protein kinase. (590 aa)
pdgfaPlatelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (230 aa)
ppp2r5dSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (569 aa)
traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (571 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (593 aa)
erbb3Protein kinase domain-containing protein. (1151 aa)
ENSHBUP00000007276Receptor protein-tyrosine kinase. (587 aa)
hgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
pip5k1cPhosphatidylinositol-4-phosphate 5-kinase, type I, gamma a. (733 aa)
ENSHBUP00000008836Uncharacterized protein. (394 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (255 aa)
LOC102303337Heparin-binding EGF-like growth factor a. (239 aa)
fgfr2Fibroblast growth factor receptor. (835 aa)
LOC102307534V-set domain containing T cell activation inhibitor 1. (276 aa)
LOC102291943Family with sequence similarity 102 member Aa. (410 aa)
ENSHBUP00000009952PH domain-containing protein. (146 aa)
LOC102289622Estrogen receptor beta a. (552 aa)
pip5k1bPhosphatidylinositol-4-phosphate 5-kinase, type I, beta a. (498 aa)
pik3ap1Phosphoinositide-3-kinase adaptor protein 1. (863 aa)
fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
LOC102296173Estrogen receptor 2b. (665 aa)
lctlLactase-like b; Belongs to the glycosyl hydrolase 1 family. (585 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC102300437Uncharacterized protein. (248 aa)
PHLPP2PH domain and leucine rich repeat protein phosphatase 2. (1440 aa)
pip5kl1Phosphatidylinositol-4-phosphate 5-kinase-like 1. (413 aa)
LOC102312174Family with sequence similarity 102 member Ab. (411 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
LOC102302326Lactase-like a; Belongs to the glycosyl hydrolase 1 family. (574 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC102292514Tyrosine-protein kinase receptor. (1365 aa)
LOC102296098Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC102303266Phosphoinositide-3-kinase, regulatory subunit 3a (gamma). (467 aa)
fndc3bFibronectin type III domain containing 3Ba. (1204 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
nrg4EGF-like domain-containing protein. (109 aa)
kitUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (987 aa)
LOC102302082Crystallin, beta B1, like 3; Belongs to the beta/gamma-crystallin family. (209 aa)
LOC102307281Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
ENSHBUP00000014471Uncharacterized protein. (97 aa)
INSCINSC spindle orientation adaptor protein. (545 aa)
ppp2r5aSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (511 aa)
il1rapUncharacterized protein. (854 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (625 aa)
LOC102298841Ras homolog family member Gb. (191 aa)
LOC102291075Fibroblast growth factor receptor. (709 aa)
LOC102310436Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
lckTyrosine-protein kinase. (501 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ENSHBUP00000018527EGF-like domain-containing protein. (102 aa)
LOC102302192Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (394 aa)
irak1Interleukin-1 receptor-associated kinase 1. (726 aa)
ptenPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (404 aa)
pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (577 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
ENSHBUP00000019390Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (284 aa)
ENSHBUP00000019721WD_REPEATS_REGION domain-containing protein. (238 aa)
ENSHBUP00000019737Uncharacterized protein. (299 aa)
LOC102304742Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
LOC102305789Transforming growth factor, alpha. (254 aa)
LOC102310023Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (515 aa)
LOC102310296Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (578 aa)
LOC102292547Family with sequence similarity 102 member Ba. (370 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
relchRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1248 aa)
PPP2R5CSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (532 aa)
fndc3aFibronectin type III domain containing 3A. (1237 aa)
ENSHBUP00000022085Recep_L_domain domain-containing protein. (166 aa)
pdgfrbPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1104 aa)
LOC102304321Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (129 aa)
LOC102312966Uncharacterized protein. (508 aa)
ppp4r1WRNPLPNID domain-containing protein. (977 aa)
LOC102297386Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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