STRINGSTRING
mcm9 mcm9 LOC102290684 LOC102290684 psma3 psma3 ccnd3 ccnd3 LOC102304617 LOC102304617 rps27a rps27a LOC102305606 LOC102305606 SRC SRC LOC102308097 LOC102308097 psmd6 psmd6 LOC102306852 LOC102306852 LOC102302267 LOC102302267 cdk2 cdk2 LOC102313461 LOC102313461 tfdp1 tfdp1 LOC102308227 LOC102308227 LOC102305723 LOC102305723 ENSHBUP00000004241 ENSHBUP00000004241 ppp4r4 ppp4r4 LOC102294096 LOC102294096 prr5l prr5l lin37 lin37 ENSHBUP00000004642 ENSHBUP00000004642 ppp2cb ppp2cb LOC102296354 LOC102296354 LOC102309506 LOC102309506 cdc6 cdc6 ccna1 ccna1 fnbp4 fnbp4 cdkn2d cdkn2d LOC102301101 LOC102301101 LOC102291159 LOC102291159 e2f2 e2f2 LOC102296758 LOC102296758 LOC102289461 LOC102289461 prim2 prim2 psmd9 psmd9 psmf1 psmf1 rbl1 rbl1 LOC102289972 LOC102289972 ENSHBUP00000006730 ENSHBUP00000006730 pole2 pole2 psma4 psma4 orc4 orc4 RPA1 RPA1 PSMD11 PSMD11 LOC102297270 LOC102297270 pole4 pole4 ccnh ccnh lin9 lin9 LOC102294243 LOC102294243 orc5 orc5 LOC102300494 LOC102300494 LOC102300798 LOC102300798 LOC102299877 LOC102299877 e2f3 e2f3 ENSHBUP00000009952 ENSHBUP00000009952 LOC102292559 LOC102292559 mcm3 mcm3 mcm6 mcm6 pola2 pola2 ENSHBUP00000010708 ENSHBUP00000010708 cdk7 cdk7 LOC102314085 LOC102314085 LOC102299917 LOC102299917 LOC102314202 LOC102314202 LOC102298027 LOC102298027 LOC102296098 LOC102296098 LOC102300709 LOC102300709 cdc45 cdc45 cdkn1b cdkn1b ppp2r3a ppp2r3a fndc3b fndc3b LOC102289344 LOC102289344 psmd12 psmd12 akt1 akt1 psma6 psma6 ppp2r3c ppp2r3c psmc2 psmc2 psma1 psma1 psmc3 psmc3 psmb1 psmb1 LOC102313340 LOC102313340 cul1 cul1 cdk6 cdk6 meiob meiob LOC102295674 LOC102295674 LOC102312634 LOC102312634 ppp2ca ppp2ca skp1 skp1 ubb ubb abl1 abl1 orc3 orc3 mnat1 mnat1 relch relch LOC102296589 LOC102296589 LOC102306295 LOC102306295 psmc6 psmc6 psmb3 psmb3 psmb2 psmb2 fndc3a fndc3a gmnn gmnn psmd10 psmd10 ENSHBUP00000022635 ENSHBUP00000022635 rb1 rb1 ppp4r1 ppp4r1 dyrk1a dyrk1a LOC102289559 LOC102289559 cdk4 cdk4 LOC102304719 LOC102304719 LOC102313157 LOC102313157 psmd14 psmd14 psmc4 psmc4 psme3 psme3 psmd1 psmd1 mybl2 mybl2 skp2 skp2 psma5 psma5 mcm7 mcm7 cdc7 cdc7 mcm4 mcm4 psmd5 psmd5 ENSHBUP00000025643 ENSHBUP00000025643 pole pole uba52 uba52 rpa2 rpa2 kxd1 kxd1 cables1 cables1 psmd8 psmd8 LOC102309509 LOC102309509 LOC102298085 LOC102298085 psmd7 psmd7 CDC25B CDC25B LOC102292517 LOC102292517 LOC102301120 LOC102301120 dyrk1b dyrk1b PPP2R3B PPP2R3B psma2 psma2 ENSHBUP00000027954 ENSHBUP00000027954 prim1 prim1 cables2 cables2 lin54 lin54 e2f4 e2f4 e2f1 e2f1 psmc1 psmc1 ccnd1 ccnd1 psme2 psme2 mcm2 mcm2 rpa3 rpa3 LOC102311728 LOC102311728 ENSHBUP00000030614 ENSHBUP00000030614 LOC102314666 LOC102314666 psmc5 psmc5 orc2 orc2 LOC102297192 LOC102297192 ENSHBUP00000034482 ENSHBUP00000034482 pola1 pola1 ccne1 ccne1 mcm5 mcm5 LOC102301826 LOC102301826 orc1 orc1 psme1 psme1 psmb4 psmb4 wee2 wee2 psmd2 psmd2 wee1 wee1 mcm10 mcm10 mcm8 mcm8 cdt1 cdt1 rpa1 rpa1 LOC102301386 LOC102301386 CKS2 CKS2 psmd13 psmd13 ccna2 ccna2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1169 aa)
LOC102290684Serine/threonine-protein phosphatase. (309 aa)
psma3Proteasome subunit alpha type. (255 aa)
ccnd3Cyclin D3; Belongs to the cyclin family. (311 aa)
LOC102304617Cyclin-dependent kinase inhibitor 1A. (169 aa)
rps27aRibosomal protein S27a. (156 aa)
LOC102305606Proteasome subunit beta. (281 aa)
SRCTyrosine-protein kinase. (550 aa)
LOC102308097Tyrosine-protein kinase. (1060 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
LOC102306852Uncharacterized protein. (178 aa)
LOC102302267Proteasome 26S subunit, non-ATPase 4b. (375 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC102313461Proteasome subunit beta. (304 aa)
tfdp1Transcription factor. (343 aa)
LOC102308227Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (445 aa)
LOC102305723Proteasome 26S subunit, non-ATPase 11b. (422 aa)
ENSHBUP00000004241Polymerase (DNA directed), epsilon 3 (p17 subunit). (147 aa)
ppp4r4Protein phosphatase 4, regulatory subunit 4. (935 aa)
LOC102294096Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (294 aa)
prr5lUncharacterized protein. (367 aa)
lin37Lin-37 DREAM MuvB core complex component. (231 aa)
ENSHBUP00000004642Uncharacterized protein. (257 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
LOC102296354Proteasome subunit beta. (286 aa)
LOC102309506Tyrosine-protein kinase. (1131 aa)
cdc6Cell division cycle 6 homolog (S. cerevisiae). (429 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (398 aa)
fnbp4Formin binding protein 4. (895 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
LOC102301101Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
LOC102291159Retinoblastoma-like 2 (p130). (1076 aa)
e2f2Si:ch211-160f23.5. (448 aa)
LOC102296758Tyrosine-protein kinase. (590 aa)
LOC102289461Proteasome subunit beta. (278 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (513 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
psmf1Proteasome inhibitor subunit 1. (277 aa)
rbl1Retinoblastoma-like 1 (p107). (1062 aa)
LOC102289972Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
ENSHBUP00000006730Uncharacterized protein. (181 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (532 aa)
psma4Proteasome subunit alpha type. (261 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (498 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
PSMD11PCI domain-containing protein. (422 aa)
LOC102297270SCY domain-containing protein. (125 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
ccnhCyclin H; Belongs to the cyclin family. (335 aa)
lin9Lin-9 DREAM MuvB core complex component. (548 aa)
LOC102294243Cyclin D2, b; Belongs to the cyclin family. (294 aa)
orc5Origin recognition complex, subunit 5. (450 aa)
LOC102300494Proteasome subunit beta. (216 aa)
LOC102300798Proteasome subunit beta 12. (226 aa)
LOC102299877Proteasome subunit beta. (275 aa)
e2f3E2F transcription factor 3. (445 aa)
ENSHBUP00000009952PH domain-containing protein. (146 aa)
LOC102292559Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (448 aa)
mcm3DNA helicase; Belongs to the MCM family. (811 aa)
mcm6DNA helicase; Belongs to the MCM family. (828 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
ENSHBUP00000010708Rpn3_C domain-containing protein. (104 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
LOC102314085Tyrosine-protein kinase. (508 aa)
LOC102299917Cyclin D2, a; Belongs to the cyclin family. (297 aa)
LOC102314202Proteasome subunit alpha type. (246 aa)
LOC102298027DBF4 zinc finger. (433 aa)
LOC102296098Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC102300709Cyclin-dependent kinase inhibitor 1Cb. (208 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (568 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Bb. (184 aa)
ppp2r3aProtein phosphatase 2, regulatory subunit B'', alpha. (1404 aa)
fndc3bFibronectin type III domain containing 3Ba. (1204 aa)
LOC102289344Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (131 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
psma6Proteasome subunit alpha type. (246 aa)
ppp2r3cProtein phosphatase 2, regulatory subunit B'', gamma. (462 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (442 aa)
psma1Proteasome subunit alpha type. (263 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (476 aa)
psmb1Proteasome subunit beta. (237 aa)
LOC102313340Cyclin E2; Belongs to the cyclin family. (391 aa)
cul1Cullin 1b; Belongs to the cullin family. (740 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
LOC102295674Proteasome 26S subunit, non-ATPase 4a. (377 aa)
LOC102312634Cdk5 and Abl enzyme substrate 2b. (519 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
ubbUbiquitin-like domain-containing protein. (54 aa)
abl1Tyrosine-protein kinase. (1104 aa)
orc3Origin recognition complex, subunit 3. (720 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
relchRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1248 aa)
LOC102296589E2F_TDP domain-containing protein. (321 aa)
LOC102306295Proteasome subunit alpha type. (246 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (330 aa)
psmb3Proteasome subunit beta. (205 aa)
psmb2Proteasome subunit beta. (229 aa)
fndc3aFibronectin type III domain containing 3A. (1237 aa)
gmnnGeminin DNA replication inhibitor. (227 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (226 aa)
ENSHBUP00000022635Cyclin-dependent kinase inhibitor 1A. (163 aa)
rb1Retinoblastoma 1. (912 aa)
ppp4r1WRNPLPNID domain-containing protein. (977 aa)
dyrk1aDual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b. (742 aa)
LOC102289559Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (318 aa)
LOC102304719Uncharacterized protein. (181 aa)
LOC102313157Proteasome subunit beta. (275 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
psme3Proteasome activator subunit 3. (256 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (957 aa)
mybl2V-myb avian myeloblastosis viral oncogene homolog-like 2b. (626 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (416 aa)
psma5Proteasome subunit alpha type. (241 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (740 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (611 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (504 aa)
ENSHBUP00000025643ANK_REP_REGION domain-containing protein. (124 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2016 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
rpa2Replication protein A2. (293 aa)
kxd1KxDL motif containing 1. (184 aa)
cables1Cdk5 and Abl enzyme substrate 1. (540 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (265 aa)
LOC102309509E2F transcription factor 5. (385 aa)
LOC102298085Cyclin Dx; Belongs to the cyclin family. (317 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (332 aa)
CDC25BCell division cycle 25B. (571 aa)
LOC102292517THAP-type domain-containing protein. (374 aa)
LOC102301120Proteasome subunit beta. (275 aa)
dyrk1bDual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B. (691 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (580 aa)
psma2Proteasome endopeptidase complex. (164 aa)
ENSHBUP00000027954Uncharacterized protein. (115 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
cables2Cdk5 and Abl enzyme substrate 2a; Belongs to the cyclin family. (513 aa)
lin54Lin-54 DREAM MuvB core complex component. (805 aa)
e2f4E2F transcription factor 4. (385 aa)
e2f1E2F transcription factor 1. (454 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
psme2Proteasome activator subunit 2. (245 aa)
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
rpa3Replication protein A3. (122 aa)
LOC102311728E2F_TDP domain-containing protein. (307 aa)
ENSHBUP00000030614Uncharacterized protein. (95 aa)
LOC102314666Ubiquitin-like domain-containing protein. (131 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (448 aa)
orc2Origin recognition complex, subunit 2. (604 aa)
LOC102297192Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
ENSHBUP00000034482RB_B domain-containing protein. (183 aa)
pola1DNA polymerase. (1482 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (462 aa)
mcm5DNA helicase; Belongs to the MCM family. (767 aa)
LOC102301826Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (93 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (898 aa)
psme1Proteasome activator subunit 1. (230 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
wee2Wee1-like protein kinase. (578 aa)
psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (906 aa)
wee1Wee1-like protein kinase. (619 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (867 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (844 aa)
cdt1Chromatin licensing and DNA replication factor 1. (607 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
LOC102301386Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (60 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (378 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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