STRINGSTRING
rfc3 rfc3 LOC102297614 LOC102297614 eme1 eme1 recql4 recql4 mre11 mre11 dna2 dna2 rpa1 rpa1 eme2 eme2 LOC102314666 LOC102314666 slx4 slx4 chek1 chek1 rbbp8 rbbp8 palb2 palb2 rpa3 rpa3 exo1 exo1 pcna pcna rad51d rad51d xrcc2 xrcc2 kxd1 kxd1 rpa2 rpa2 uba52 uba52 pole pole spidr spidr rad51 rad51 LOC102313827 LOC102313827 RCBTB1 RCBTB1 LOC102308989 LOC102308989 nbn nbn rad50 rad50 rfc4 rfc4 brca2 brca2 ankrd11 ankrd11 kat5 kat5 ubb ubb meiob meiob polh polh exd2 exd2 pold1 pold1 top3a top3a pold4 pold4 blm blm gen1 gen1 rfc2 rfc2 SLX1 SLX1 mus81 mus81 pold2 pold2 rfc5 rfc5 ENSHBUP00000009143 ENSHBUP00000009143 ENSHBUP00000009123 ENSHBUP00000009123 rad51ap1 rad51ap1 rmi1 rmi1 pole4 pole4 RPA1 RPA1 polk polk pole2 pole2 pold3 pold3 ankrd12 ankrd12 tdrd3 tdrd3 ENSHBUP00000005062 ENSHBUP00000005062 ENSHBUP00000005048 ENSHBUP00000005048 xrcc3 xrcc3 ENSHBUP00000004241 ENSHBUP00000004241 brca1 brca1 rps27a rps27a rmi2 rmi2 rfc1 rfc1 ENSHBUP00000001804 ENSHBUP00000001804 LOC102288768 LOC102288768
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC102297614RAD51 paralog C. (359 aa)
eme1Essential meiotic structure-specific endonuclease 1. (526 aa)
recql4RecQ helicase-like 4. (1577 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (695 aa)
dna2DNA replication helicase/nuclease 2. (1401 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
eme2ERCC4 domain-containing protein. (276 aa)
LOC102314666Ubiquitin-like domain-containing protein. (131 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1628 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (460 aa)
rbbp8Uncharacterized protein. (673 aa)
palb2PALB2_WD40 domain-containing protein. (1356 aa)
rpa3Replication protein A3. (122 aa)
exo1Exonuclease 1. (737 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
rad51dRAD51 paralog D. (333 aa)
xrcc2X-ray repair cross complementing 2. (324 aa)
kxd1KxDL motif containing 1. (184 aa)
rpa2Replication protein A2. (293 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2016 aa)
spidrScaffold protein involved in DNA repair. (935 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
LOC102313827Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LOC102308989ANK_REP_REGION domain-containing protein. (698 aa)
nbnNibrin. (779 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
brca2BRCA2 DNA repair associated. (3303 aa)
ankrd11Ankyrin repeat domain 11. (2842 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (555 aa)
ubbUbiquitin-like domain-containing protein. (54 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
polhPolymerase (DNA directed), eta. (738 aa)
exd2Exonuclease 3'-5' domain containing 2. (635 aa)
pold1DNA polymerase. (1129 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa)
pold4Si:dkey-28b4.7. (107 aa)
blmBLM RecQ like helicase. (1405 aa)
gen1Uncharacterized protein. (887 aa)
rfc2Replication factor C (activator 1) 2. (356 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (256 aa)
mus81MUS81 structure-specific endonuclease subunit. (650 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (481 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
ENSHBUP00000009143AAA_23 domain-containing protein. (92 aa)
ENSHBUP00000009123Uncharacterized protein. (264 aa)
rad51ap1RAD51 associated protein 1. (331 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (679 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
polkPolymerase (DNA directed) kappa. (875 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (532 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (444 aa)
ankrd12Ankyrin repeat domain 12. (1951 aa)
tdrd3Tudor domain containing 3. (780 aa)
ENSHBUP00000005062Uncharacterized protein. (143 aa)
ENSHBUP00000005048TAN domain-containing protein. (177 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (336 aa)
ENSHBUP00000004241Polymerase (DNA directed), epsilon 3 (p17 subunit). (147 aa)
brca1Uncharacterized protein. (1388 aa)
rps27aRibosomal protein S27a. (156 aa)
rmi2RecQ mediated genome instability 2. (146 aa)
rfc1BRCT domain-containing protein. (471 aa)
ENSHBUP00000001804RFC1 domain-containing protein. (135 aa)
LOC102288768Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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