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| | LOC102288768 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa) |
| | abraxas1 | Abraxas 1, BRCA1 A complex subunit. (346 aa) |
| | LOC102290216 | Histone H2A; Belongs to the histone H2A family. (138 aa) |
| | polq | Polymerase (DNA directed), theta. (2129 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1710 aa) |
| | ENSHBUP00000001804 | RFC1 domain-containing protein. (135 aa) |
| | rfc1 | BRCT domain-containing protein. (471 aa) |
| | rmi2 | RecQ mediated genome instability 2. (146 aa) |
| | rps27a | Ribosomal protein S27a. (156 aa) |
| | ENSHBUP00000002798 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | brca1 | Uncharacterized protein. (1388 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (378 aa) |
| | ENSHBUP00000004241 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (147 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (336 aa) |
| | ENSHBUP00000005048 | TAN domain-containing protein. (177 aa) |
| | ENSHBUP00000005062 | Uncharacterized protein. (143 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | ccna1 | Cyclin A1; Belongs to the cyclin family. (398 aa) |
| | ENSHBUP00000005490 | Reverse transcriptase domain-containing protein. (348 aa) |
| | tdrd3 | Tudor domain containing 3. (780 aa) |
| | parp2 | Poly [ADP-ribose] polymerase. (528 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | LOC102290507 | Uncharacterized protein. (429 aa) |
| | ankrd12 | Ankyrin repeat domain 12. (1951 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (444 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (532 aa) |
| | polk | Polymerase (DNA directed) kappa. (875 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (311 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa) |
| | ENSHBUP00000008246 | Uncharacterized protein. (117 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (679 aa) |
| | rad51ap1 | RAD51 associated protein 1. (331 aa) |
| | slf1 | SMC5-SMC6 complex localization factor 1. (885 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | ENSHBUP00000009123 | Uncharacterized protein. (264 aa) |
| | ENSHBUP00000009143 | AAA_23 domain-containing protein. (92 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (481 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (650 aa) |
| | uimc1 | RAP80_UIM domain-containing protein. (848 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (256 aa) |
| | rhno1 | Si:ch73-352p4.5. (295 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (400 aa) |
| | ENSHBUP00000011390 | BRCA1/BRCA2-containing complex, subunit 3. (266 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (559 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (356 aa) |
| | gen1 | Uncharacterized protein. (887 aa) |
| | LOC102299037 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (3139 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1538 aa) |
| | ENSHBUP00000013671 | Reverse transcriptase domain-containing protein. (397 aa) |
| | LOC102289514 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (182 aa) |
| | blm | BLM RecQ like helicase. (1405 aa) |
| | pold4 | Si:dkey-28b4.7. (107 aa) |
| | LOC102294941 | Small ubiquitin-related modifier. (96 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (464 aa) |
| | pold1 | DNA polymerase. (1129 aa) |
| | cdca7 | Cell division cycle associated 7a. (401 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (635 aa) |
| | polh | Polymerase (DNA directed), eta. (738 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (464 aa) |
| | sirt6 | Sirtuin 6. (351 aa) |
| | ubb | Ubiquitin-like domain-containing protein. (54 aa) |
| | rnf169 | Ring finger protein 169. (585 aa) |
| | abl1 | Tyrosine-protein kinase. (1104 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (555 aa) |
| | ankrd11 | Ankyrin repeat domain 11. (2842 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (390 aa) |
| | brca2 | BRCA2 DNA repair associated. (3303 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (357 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | SUMO3 | Small ubiquitin-related modifier. (94 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | LOC102289538 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | ENSHBUP00000023288 | Histone H2B; Belongs to the histone H2B family. (128 aa) |
| | ENSHBUP00000023290 | Uncharacterized protein. (125 aa) |
| | timeless | Timeless circadian clock. (1249 aa) |
| | nbn | Nibrin. (779 aa) |
| | ube2i | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | LOC102308989 | ANK_REP_REGION domain-containing protein. (698 aa) |
| | ENSHBUP00000024446 | Histone H2B; Belongs to the histone H2B family. (135 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | pias4 | Protein inhibitor of activated STAT, 4a. (507 aa) |
| | LOC102312440 | Small ubiquitin-related modifier. (94 aa) |
| | LOC102313827 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa) |
| | LOC102291787 | Zgc:110269. (388 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa) |
| | spidr | Scaffold protein involved in DNA repair. (935 aa) |
| | ENSHBUP00000025640 | Reverse transcriptase domain-containing protein. (416 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2016 aa) |
| | LOC102293513 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | rnf168 | Ring finger protein 168. (419 aa) |
| | uba52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | rpa2 | Replication protein A2. (293 aa) |
| | ENSHBUP00000026636 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa) |
| | kxd1 | KxDL motif containing 1. (184 aa) |
| | xrcc2 | X-ray repair cross complementing 2. (324 aa) |
| | nsd2 | Nuclear receptor binding SET domain protein 2. (1313 aa) |
| | ENSHBUP00000027528 | Uncharacterized protein. (252 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa) |
| | ppp4r2 | Protein phosphatase 4, regulatory subunit 2b. (434 aa) |
| | sumo2 | Ubiquitin-like domain-containing protein. (143 aa) |
| | ENSHBUP00000028115 | Reverse transcriptase domain-containing protein. (365 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | ENSHBUP00000029115 | Uncharacterized protein. (166 aa) |
| | LOC102311858 | Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | atrip | Uncharacterized protein. (789 aa) |
| | lig3 | DNA ligase. (1012 aa) |
| | rad51d | RAD51 paralog D. (333 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | exo1 | Exonuclease 1. (737 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | palb2 | PALB2_WD40 domain-containing protein. (1356 aa) |
| | rbbp8 | Uncharacterized protein. (673 aa) |
| | chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (460 aa) |
| | slx4 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1628 aa) |
| | LOC102314666 | Ubiquitin-like domain-containing protein. (131 aa) |
| | mdc1 | Uncharacterized protein. (2081 aa) |
| | eme2 | ERCC4 domain-containing protein. (276 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa) |
| | xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (627 aa) |
| | dna2 | DNA replication helicase/nuclease 2. (1401 aa) |
| | rad1 | RAD1 homolog (S. pombe). (309 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (695 aa) |
| | sirt7 | Sirtuin 7. (405 aa) |
| | recql4 | RecQ helicase-like 4. (1577 aa) |
| | ccna2 | Cyclin A2; Belongs to the cyclin family. (434 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (526 aa) |
| | cdca7l | Cell division cycle associated 7b. (402 aa) |
| | LOC102297614 | RAD51 paralog C. (359 aa) |
| | ENSHBUP00000033958 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (229 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (692 aa) |
