STRINGSTRING
LOC102314666 LOC102314666 LOC102299753 LOC102299753 mdc1 mdc1 rnf8 rnf8 chek2 chek2 eya1 eya1 ubb ubb rnf169 rnf169 abl1 abl1 kat5 kat5 ankrd11 ankrd11 LOC102296334 LOC102296334 rad50 rad50 LOC102289538 LOC102289538 ENSHBUP00000023288 ENSHBUP00000023288 ENSHBUP00000023290 ENSHBUP00000023290 nbn nbn ube2i ube2i LOC102308989 LOC102308989 ENSHBUP00000024446 ENSHBUP00000024446 pias4 pias4 ENSHBUP00000025640 ENSHBUP00000025640 LOC102293513 LOC102293513 rnf168 rnf168 uba52 uba52 ENSHBUP00000026636 ENSHBUP00000026636 smarca5 smarca5 kxd1 kxd1 mre11 mre11 nsd2 nsd2 ENSHBUP00000027528 ENSHBUP00000027528 ENSHBUP00000028115 ENSHBUP00000028115 ENSHBUP00000029115 ENSHBUP00000029115 LOC102311858 LOC102311858 abraxas1 abraxas1 LOC102290216 LOC102290216 tp53bp1 tp53bp1 ppp5c ppp5c rps27a rps27a ENSHBUP00000002798 ENSHBUP00000002798 brca1 brca1 babam1 babam1 ENSHBUP00000005048 ENSHBUP00000005048 ENSHBUP00000005062 ENSHBUP00000005062 ENSHBUP00000005490 ENSHBUP00000005490 ube2v2 ube2v2 ankrd12 ankrd12 sumo1 sumo1 ENSHBUP00000009123 ENSHBUP00000009123 ENSHBUP00000009143 ENSHBUP00000009143 uimc1 uimc1 babam2 babam2 ENSHBUP00000011390 ENSHBUP00000011390 eya4 eya4 LOC102299037 LOC102299037 baz1b baz1b ENSHBUP00000013671 ENSHBUP00000013671 LOC102301954 LOC102301954 LOC102289514 LOC102289514 LOC102288671 LOC102288671 apbb1 apbb1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102314666Ubiquitin-like domain-containing protein. (131 aa)
LOC102299753Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (607 aa)
mdc1Uncharacterized protein. (2081 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (464 aa)
chek2Checkpoint kinase 2. (521 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa)
ubbUbiquitin-like domain-containing protein. (54 aa)
rnf169Ring finger protein 169. (585 aa)
abl1Tyrosine-protein kinase. (1104 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (555 aa)
ankrd11Ankyrin repeat domain 11. (2842 aa)
LOC102296334Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
LOC102289538Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSHBUP00000023288Histone H2B; Belongs to the histone H2B family. (128 aa)
ENSHBUP00000023290Uncharacterized protein. (125 aa)
nbnNibrin. (779 aa)
ube2iUbiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
LOC102308989ANK_REP_REGION domain-containing protein. (698 aa)
ENSHBUP00000024446Histone H2B; Belongs to the histone H2B family. (135 aa)
pias4Protein inhibitor of activated STAT, 4a. (507 aa)
ENSHBUP00000025640Reverse transcriptase domain-containing protein. (416 aa)
LOC102293513Histone H2B; Belongs to the histone H2B family. (116 aa)
rnf168Ring finger protein 168. (419 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
ENSHBUP00000026636Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (104 aa)
smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (790 aa)
kxd1KxDL motif containing 1. (184 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (695 aa)
nsd2Nuclear receptor binding SET domain protein 2. (1313 aa)
ENSHBUP00000027528Uncharacterized protein. (252 aa)
ENSHBUP00000028115Reverse transcriptase domain-containing protein. (365 aa)
ENSHBUP00000029115Uncharacterized protein. (166 aa)
LOC102311858Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (346 aa)
LOC102290216Histone H2A; Belongs to the histone H2A family. (138 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1710 aa)
ppp5cSerine/threonine-protein phosphatase. (491 aa)
rps27aRibosomal protein S27a. (156 aa)
ENSHBUP00000002798Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
brca1Uncharacterized protein. (1388 aa)
babam1BRISC and BRCA1 A complex member 1. (378 aa)
ENSHBUP00000005048TAN domain-containing protein. (177 aa)
ENSHBUP00000005062Uncharacterized protein. (143 aa)
ENSHBUP00000005490Reverse transcriptase domain-containing protein. (348 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
ankrd12Ankyrin repeat domain 12. (1951 aa)
sumo1Small ubiquitin like modifier 1. (129 aa)
ENSHBUP00000009123Uncharacterized protein. (264 aa)
ENSHBUP00000009143AAA_23 domain-containing protein. (92 aa)
uimc1RAP80_UIM domain-containing protein. (848 aa)
babam2BRISC and BRCA1 A complex member 2. (400 aa)
ENSHBUP00000011390BRCA1/BRCA2-containing complex, subunit 3. (266 aa)
eya4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (649 aa)
LOC102299037UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
baz1bBromodomain adjacent to zinc finger domain, 1B. (1641 aa)
ENSHBUP00000013671Reverse transcriptase domain-containing protein. (397 aa)
LOC102301954Lysine (K)-specific demethylase 4B. (1067 aa)
LOC102289514UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (182 aa)
LOC102288671Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (529 aa)
apbb1Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (679 aa)
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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