49 items (Haplochromis burtoni) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ercc5	Excision repair cross-complementation group 5. (1113 aa)
	LOC102288768	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (692 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (461 aa)
	ENSHBUP00000001804	RFC1 domain-containing protein. (135 aa)
	rfc1	BRCT domain-containing protein. (471 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	ENSHBUP00000004241	Polymerase (DNA directed), epsilon 3 (p17 subunit). (147 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	parp2	Poly [ADP-ribose] polymerase. (528 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (444 aa)
	ddb1	Damage-specific DNA binding protein 1. (1140 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (532 aa)
	polk	Polymerase (DNA directed) kappa. (875 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (481 aa)
	parp3	Poly [ADP-ribose] polymerase. (559 aa)
	bivm	Basic, immunoglobulin-like variable motif containing. (496 aa)
	rfc2	Replication factor C (activator 1) 2. (356 aa)
	pold4	Si:dkey-28b4.7. (107 aa)
	ercc4	Excision repair cross-complementation group 4. (899 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (865 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
	pold1	DNA polymerase. (1129 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (550 aa)
	ubb	Ubiquitin-like domain-containing protein. (54 aa)
	ercc1	Excision repair cross-complementation group 1. (352 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	ercc3	Excision repair cross-complementation group 3. (783 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	LOC102313827	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa)
	chd1l	Chromodomain helicase DNA binding protein 1-like. (994 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2016 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (305 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	rpa2	Replication protein A2. (293 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rpa3	Replication protein A3. (122 aa)
	LOC102314666	Ubiquitin-like domain-containing protein. (131 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (271 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
	ddb2	Damage-specific DNA binding protein 2. (490 aa)
	LOC102292669	General transcription factor IIH subunit. (392 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000001804	ENSHBUP00000004241	ENSHBUP00000001804	ENSHBUP00000004241	RFC1 domain-containing protein.	Polymerase (DNA directed), epsilon 3 (p17 subunit).	0.833
ENSHBUP00000001804	LOC102314666	ENSHBUP00000001804	ENSHBUP00000031002	RFC1 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.719
ENSHBUP00000001804	RPA1	ENSHBUP00000001804	ENSHBUP00000007812	RFC1 domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.886
ENSHBUP00000001804	bivm	ENSHBUP00000001804	ENSHBUP00000012063	RFC1 domain-containing protein.	Basic, immunoglobulin-like variable motif containing.	0.788
ENSHBUP00000001804	chd1l	ENSHBUP00000001804	ENSHBUP00000025423	RFC1 domain-containing protein.	Chromodomain helicase DNA binding protein 1-like.	0.543
ENSHBUP00000001804	cul4a	ENSHBUP00000001804	ENSHBUP00000000595	RFC1 domain-containing protein.	Cullin 4A; Belongs to the cullin family.	0.648
ENSHBUP00000001804	cul4b	ENSHBUP00000001804	ENSHBUP00000015278	RFC1 domain-containing protein.	Cullin 4B; Belongs to the cullin family.	0.648
ENSHBUP00000001804	ddb1	ENSHBUP00000001804	ENSHBUP00000007296	RFC1 domain-containing protein.	Damage-specific DNA binding protein 1.	0.664
ENSHBUP00000001804	ddb2	ENSHBUP00000001804	ENSHBUP00000032136	RFC1 domain-containing protein.	Damage-specific DNA binding protein 2.	0.533
ENSHBUP00000001804	ercc1	ENSHBUP00000001804	ENSHBUP00000022312	RFC1 domain-containing protein.	Excision repair cross-complementation group 1.	0.512
ENSHBUP00000001804	ercc2	ENSHBUP00000001804	ENSHBUP00000000975	RFC1 domain-containing protein.	Excision repair cross-complementation group 2.	0.728
ENSHBUP00000001804	ercc4	ENSHBUP00000001804	ENSHBUP00000014336	RFC1 domain-containing protein.	Excision repair cross-complementation group 4.	0.873
ENSHBUP00000001804	ercc5	ENSHBUP00000001804	ENSHBUP00000000451	RFC1 domain-containing protein.	Excision repair cross-complementation group 5.	0.788
ENSHBUP00000001804	gtf2h1	ENSHBUP00000001804	ENSHBUP00000017300	RFC1 domain-containing protein.	General transcription factor IIH, polypeptide 1.	0.673
ENSHBUP00000001804	gtf2h5	ENSHBUP00000001804	ENSHBUP00000006450	RFC1 domain-containing protein.	General transcription factor IIH, polypeptide 5.	0.431
ENSHBUP00000001804	parp1	ENSHBUP00000001804	ENSHBUP00000008939	RFC1 domain-containing protein.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.554
ENSHBUP00000001804	parp2	ENSHBUP00000001804	ENSHBUP00000005986	RFC1 domain-containing protein.	Poly [ADP-ribose] polymerase.	0.566
ENSHBUP00000001804	parp3	ENSHBUP00000001804	ENSHBUP00000011511	RFC1 domain-containing protein.	Poly [ADP-ribose] polymerase.	0.516
ENSHBUP00000001804	pcna	ENSHBUP00000001804	ENSHBUP00000029821	RFC1 domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.984
ENSHBUP00000001804	pold1	ENSHBUP00000001804	ENSHBUP00000017205	RFC1 domain-containing protein.	DNA polymerase.	0.857