43 items (Haplochromis burtoni) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2516 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (434 aa)
	LOC102301386	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	LOC102314666	Ubiquitin-like domain-containing protein. (131 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1704 aa)
	LOC102293967	PR domain containing 1a, with ZNF domain. (763 aa)
	ENSHBUP00000029663	Uncharacterized protein. (151 aa)
	chek2	Checkpoint kinase 2. (521 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1112 aa)
	rffl	Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase. (346 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	rnf34	Ring finger protein 34a. (378 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (307 aa)
	LOC102301602	PR/SET domain 1. (730 aa)
	LOC102296098	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (398 aa)
	LOC102299999	Uncharacterized protein. (477 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	mdm2	MDM2 proto-oncogene. (522 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	LOC102290684	Serine/threonine-protein phosphatase. (309 aa)
	LOC102303686	PR domain containing 1b, with ZNF domain. (599 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	ENSHBUP00000005048	TAN domain-containing protein. (177 aa)
	ENSHBUP00000005062	Uncharacterized protein. (143 aa)
	txndc11	Thioredoxin domain containing 11. (858 aa)
	mapkap1	MAPK associated protein 1. (529 aa)
	LOC102301101	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
	LOC102314329	Ubiquitin carboxyl-terminal hydrolase. (574 aa)
	SGK1	Non-specific serine/threonine protein kinase. (626 aa)
	LOC102295930	Ubiquitin carboxyl-terminal hydrolase. (414 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (495 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (565 aa)
	LOC102296334	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
	ubb	Ubiquitin-like domain-containing protein. (54 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	ENSHBUP00000009952	PH domain-containing protein. (146 aa)
	phf20	PHD finger protein 20, a. (1003 aa)
	mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae). (326 aa)
	LOC102297192	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	LOC102300128	Ring finger protein 34b. (419 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000005048	ENSHBUP00000005062	ENSHBUP00000005048	ENSHBUP00000005062	TAN domain-containing protein.	Uncharacterized protein.	0.923
ENSHBUP00000005048	ENSHBUP00000009952	ENSHBUP00000005048	ENSHBUP00000009952	TAN domain-containing protein.	PH domain-containing protein.	0.510
ENSHBUP00000005048	LOC102296098	ENSHBUP00000005048	ENSHBUP00000011927	TAN domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.510
ENSHBUP00000005048	LOC102296334	ENSHBUP00000005048	ENSHBUP00000022213	TAN domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.989
ENSHBUP00000005048	LOC102297192	ENSHBUP00000005048	ENSHBUP00000034621	TAN domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.510
ENSHBUP00000005048	LOC102301101	ENSHBUP00000005048	ENSHBUP00000005571	TAN domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.510
ENSHBUP00000005048	LOC102314666	ENSHBUP00000005048	ENSHBUP00000031002	TAN domain-containing protein.	Ubiquitin-like domain-containing protein.	0.677
ENSHBUP00000005048	akt1	ENSHBUP00000005048	ENSHBUP00000014267	TAN domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.510
ENSHBUP00000005048	ccna1	ENSHBUP00000005048	ENSHBUP00000005298	TAN domain-containing protein.	Cyclin A1; Belongs to the cyclin family.	0.705
ENSHBUP00000005048	ccna2	ENSHBUP00000005048	ENSHBUP00000032902	TAN domain-containing protein.	Cyclin A2; Belongs to the cyclin family.	0.705
ENSHBUP00000005048	cdk1	ENSHBUP00000005048	ENSHBUP00000012669	TAN domain-containing protein.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.691
ENSHBUP00000005048	cdk2	ENSHBUP00000005048	ENSHBUP00000003403	TAN domain-containing protein.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.682
ENSHBUP00000005048	chek2	ENSHBUP00000005048	ENSHBUP00000017690	TAN domain-containing protein.	Checkpoint kinase 2.	0.988
ENSHBUP00000005048	mdm2	ENSHBUP00000005048	ENSHBUP00000002884	TAN domain-containing protein.	MDM2 proto-oncogene.	0.890
ENSHBUP00000005048	mdm4	ENSHBUP00000005048	ENSHBUP00000024857	TAN domain-containing protein.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.843
ENSHBUP00000005048	mtor	ENSHBUP00000005048	ENSHBUP00000032917	TAN domain-containing protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.729
ENSHBUP00000005048	rps27a	ENSHBUP00000005048	ENSHBUP00000002167	TAN domain-containing protein.	Ribosomal protein S27a.	0.648
ENSHBUP00000005062	ENSHBUP00000005048	ENSHBUP00000005062	ENSHBUP00000005048	Uncharacterized protein.	TAN domain-containing protein.	0.923
ENSHBUP00000005062	ENSHBUP00000009952	ENSHBUP00000005062	ENSHBUP00000009952	Uncharacterized protein.	PH domain-containing protein.	0.510
ENSHBUP00000005062	LOC102296098	ENSHBUP00000005062	ENSHBUP00000011927	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.510