STRINGSTRING
gins1 gins1 pole2 pole2 pold3 pold3 LOC102305723 LOC102305723 LOC102300113 LOC102300113 LOC102313461 LOC102313461 cdk2 cdk2 LOC102302267 LOC102302267 LOC102306852 LOC102306852 psmd6 psmd6 LOC102301505 LOC102301505 LOC102305606 LOC102305606 rps27a rps27a ENSHBUP00000002040 ENSHBUP00000002040 pds5a pds5a LOC102304617 LOC102304617 rfc1 rfc1 ENSHBUP00000001804 ENSHBUP00000001804 psma3 psma3 LOC102288768 LOC102288768 cdca5 cdca5 anapc7 anapc7 mcm9 mcm9 ube2c ube2c ENSHBUP00000006730 ENSHBUP00000006730 LOC102289972 LOC102289972 lig1 lig1 psmf1 psmf1 psmd9 psmd9 prim2 prim2 LOC102312282 LOC102312282 LOC102312912 LOC102312912 LOC102289461 LOC102289461 LOC102301101 LOC102301101 ccna1 ccna1 cdc6 cdc6 rfc3 rfc3 LOC102296354 LOC102296354 pds5b pds5b ENSHBUP00000004642 ENSHBUP00000004642 LOC102294096 LOC102294096 psmc5 psmc5 LOC102307191 LOC102307191 orc2 orc2 LOC102297192 LOC102297192 pola1 pola1 ccne1 ccne1 mcm5 mcm5 LOC102301826 LOC102301826 orc1 orc1 psme1 psme1 ccna2 ccna2 anapc2 anapc2 psmd13 psmd13 cdc26 cdc26 CKS2 CKS2 LOC102300965 LOC102300965 dna2 dna2 rpa1 rpa1 cdt1 cdt1 mcm8 mcm8 wee1 wee1 psmd2 psmd2 wee2 wee2 smc3 smc3 psmb4 psmb4 LOC102314666 LOC102314666 gins2 gins2 LOC102306691 LOC102306691 ENSHBUP00000030614 ENSHBUP00000030614 anapc15 anapc15 rpa3 rpa3 pcna pcna mcm2 mcm2 anapc4 anapc4 esco2 esco2 psme2 psme2 ccnd1 ccnd1 psmc1 psmc1 anapc5 anapc5 fen1 fen1 cables2 cables2 prim1 prim1 tm7sf3 tm7sf3 psma2 psma2 LOC102301120 LOC102301120 CDC25B CDC25B psmd7 psmd7 psmd8 psmd8 cables1 cables1 kxd1 kxd1 rpa2 rpa2 uba52 uba52 bicral bicral pole pole psmd5 psmd5 mcm4 mcm4 stag3 stag3 ENSHBUP00000004241 ENSHBUP00000004241 mcm7 mcm7 LOC102291787 LOC102291787 LOC102313827 LOC102313827 psma5 psma5 skp2 skp2 anapc1 anapc1 psmd1 psmd1 RCBTB1 RCBTB1 psme3 psme3 psmc4 psmc4 psma8 psma8 psmd14 psmd14 LOC102313157 LOC102313157 LOC102304719 LOC102304719 cdk4 cdk4 smc1a smc1a rb1 rb1 ENSHBUP00000022635 ENSHBUP00000022635 psmd10 psmd10 LOC102307802 LOC102307802 gmnn gmnn rfc4 rfc4 anapc11 anapc11 psmb2 psmb2 psmb3 psmb3 psmc6 psmc6 LOC102306295 LOC102306295 RAD21 RAD21 mnat1 mnat1 orc3 orc3 FZR1 FZR1 cdc23 cdc23 ubb ubb skp1 skp1 LOC102312634 LOC102312634 LOC102295674 LOC102295674 gins3 gins3 meiob meiob LOC102307929 LOC102307929 pold1 pold1 cul1 cul1 anapc16 anapc16 LOC102313340 LOC102313340 psmb1 psmb1 psmc3 psmc3 rbx1 rbx1 psma1 psma1 psmc2 psmc2 psma6 psma6 LOC102304191 LOC102304191 pold4 pold4 akt1 akt1 psmd12 psmd12 cdc27 cdc27 LOC102292505 LOC102292505 LOC102312405 LOC102312405 cdkn1b cdkn1b stag1 stag1 rfc2 rfc2 fam89a fam89a LOC102300709 LOC102300709 LOC102296098 LOC102296098 ube2s ube2s LOC102313370 LOC102313370 LOC102314202 LOC102314202 LOC102314085 LOC102314085 LOC102289767 LOC102289767 cdk7 cdk7 ENSHBUP00000010708 ENSHBUP00000010708 gins4 gins4 pola2 pola2 mcm6 mcm6 mcm3 mcm3 ENSHBUP00000009952 ENSHBUP00000009952 cdc16 cdc16 LOC102292095 LOC102292095 LOC102310266 LOC102310266 anapc10 anapc10 LOC102299877 LOC102299877 pold2 pold2 LOC102300798 LOC102300798 LOC102300494 LOC102300494 rfc5 rfc5 orc5 orc5 bicra bicra ccnh ccnh pole4 pole4 LOC102297270 LOC102297270 PSMD11 PSMD11 RPA1 RPA1 psme4 psme4 wapl wapl orc4 orc4 psma4 psma4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gins1GINS complex subunit 1 (Psf1 homolog). (212 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (532 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (444 aa)
LOC102305723Proteasome 26S subunit, non-ATPase 11b. (422 aa)
LOC102300113WD_REPEATS_REGION domain-containing protein. (489 aa)
LOC102313461Proteasome subunit beta. (304 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC102302267Proteasome 26S subunit, non-ATPase 4b. (375 aa)
LOC102306852Uncharacterized protein. (178 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
LOC102301505Stromal antigen 2a. (1276 aa)
LOC102305606Proteasome subunit beta. (281 aa)
rps27aRibosomal protein S27a. (156 aa)
ENSHBUP00000002040Proteasome subunit beta. (299 aa)
pds5aPDS5 cohesin associated factor A. (1294 aa)
LOC102304617Cyclin-dependent kinase inhibitor 1A. (169 aa)
rfc1BRCT domain-containing protein. (471 aa)
ENSHBUP00000001804RFC1 domain-containing protein. (135 aa)
psma3Proteasome subunit alpha type. (255 aa)
LOC102288768Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
cdca5Cell division cycle associated 5. (260 aa)
anapc7Anaphase promoting complex subunit 7. (565 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1169 aa)
ube2cUbiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (199 aa)
ENSHBUP00000006730Uncharacterized protein. (181 aa)
LOC102289972Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
lig1DNA ligase. (1012 aa)
psmf1Proteasome inhibitor subunit 1. (277 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (513 aa)
LOC102312282Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
LOC102312912UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (194 aa)
LOC102289461Proteasome subunit beta. (278 aa)
LOC102301101Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (398 aa)
cdc6Cell division cycle 6 homolog (S. cerevisiae). (429 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC102296354Proteasome subunit beta. (286 aa)
pds5bPDS5 cohesin associated factor B. (1409 aa)
ENSHBUP00000004642Uncharacterized protein. (257 aa)
LOC102294096Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (294 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (448 aa)
LOC102307191Proteasome subunit beta11b. (362 aa)
orc2Origin recognition complex, subunit 2. (604 aa)
LOC102297192Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
pola1DNA polymerase. (1482 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (462 aa)
mcm5DNA helicase; Belongs to the MCM family. (767 aa)
LOC102301826Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (93 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (898 aa)
psme1Proteasome activator subunit 1. (230 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (646 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (378 aa)
cdc26Cell division cycle 26 homolog. (87 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (60 aa)
LOC102300965Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (218 aa)
dna2DNA replication helicase/nuclease 2. (1401 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
cdt1Chromatin licensing and DNA replication factor 1. (607 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (844 aa)
wee1Wee1-like protein kinase. (619 aa)
psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (906 aa)
wee2Wee1-like protein kinase. (578 aa)
smc3Structural maintenance of chromosomes protein. (1217 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
LOC102314666Ubiquitin-like domain-containing protein. (131 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (175 aa)
LOC102306691zf-C2H2_3 domain-containing protein. (2839 aa)
ENSHBUP00000030614Uncharacterized protein. (95 aa)
anapc15Anaphase promoting complex subunit 15. (122 aa)
rpa3Replication protein A3. (122 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
anapc4Anaphase promoting complex subunit 4. (756 aa)
esco2Establishment of sister chromatid cohesion N-acetyltransferase 2. (664 aa)
psme2Proteasome activator subunit 2. (245 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
anapc5Anaphase promoting complex subunit 5. (771 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
cables2Cdk5 and Abl enzyme substrate 2a; Belongs to the cyclin family. (513 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
tm7sf3Transmembrane 7 superfamily member 3. (565 aa)
psma2Proteasome endopeptidase complex. (164 aa)
LOC102301120Proteasome subunit beta. (275 aa)
CDC25BCell division cycle 25B. (571 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (332 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (265 aa)
cables1Cdk5 and Abl enzyme substrate 1. (540 aa)
kxd1KxDL motif containing 1. (184 aa)
rpa2Replication protein A2. (293 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
bicralBRD4 interacting chromatin remodeling complex associated protein like. (797 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2016 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (504 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
stag3SCD domain-containing protein. (1191 aa)
ENSHBUP00000004241Polymerase (DNA directed), epsilon 3 (p17 subunit). (147 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (740 aa)
LOC102291787Zgc:110269. (388 aa)
LOC102313827Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa)
psma5Proteasome subunit alpha type. (241 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (416 aa)
anapc1Anaphase promoting complex subunit 1. (1982 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (957 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
psme3Proteasome activator subunit 3. (256 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
psma8Proteasome subunit alpha type. (296 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
LOC102313157Proteasome subunit beta. (275 aa)
LOC102304719Uncharacterized protein. (181 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (318 aa)
smc1aStructural maintenance of chromosomes protein. (1231 aa)
rb1Retinoblastoma 1. (912 aa)
ENSHBUP00000022635Cyclin-dependent kinase inhibitor 1A. (163 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (226 aa)
LOC102307802Stromal antigen 2b. (1249 aa)
gmnnGeminin DNA replication inhibitor. (227 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (94 aa)
psmb2Proteasome subunit beta. (229 aa)
psmb3Proteasome subunit beta. (205 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (330 aa)
LOC102306295Proteasome subunit alpha type. (246 aa)
RAD21RAD21 cohesin complex component. (648 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
orc3Origin recognition complex, subunit 3. (720 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (496 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (575 aa)
ubbUbiquitin-like domain-containing protein. (54 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
LOC102312634Cdk5 and Abl enzyme substrate 2b. (519 aa)
LOC102295674Proteasome 26S subunit, non-ATPase 4a. (377 aa)
gins3GINS complex subunit 3. (211 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
LOC102307929Proteasome activator subunit 4b. (1804 aa)
pold1DNA polymerase. (1129 aa)
cul1Cullin 1b; Belongs to the cullin family. (740 aa)
anapc16Anaphase promoting complex subunit 16. (108 aa)
LOC102313340Cyclin E2; Belongs to the cyclin family. (391 aa)
psmb1Proteasome subunit beta. (237 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (476 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
psma1Proteasome subunit alpha type. (263 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (442 aa)
psma6Proteasome subunit alpha type. (246 aa)
LOC102304191Structural maintenance of chromosomes protein. (1245 aa)
pold4Si:dkey-28b4.7. (107 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
cdc27Cell division cycle 27. (802 aa)
LOC102292505Fizzy/cell division cycle 20 related 1b. (532 aa)
LOC102312405ATPase family AAA domain containing 5a. (1808 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Bb. (184 aa)
stag1Stromal antigen 1a. (1260 aa)
rfc2Replication factor C (activator 1) 2. (356 aa)
fam89aFamily with sequence similarity 89 member A. (180 aa)
LOC102300709Cyclin-dependent kinase inhibitor 1Cb. (208 aa)
LOC102296098Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ube2sUbiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (233 aa)
LOC102313370WAPL cohesin release factor b. (1213 aa)
LOC102314202Proteasome subunit alpha type. (246 aa)
LOC102314085Tyrosine-protein kinase. (508 aa)
LOC102289767RAD21 cohesin complex component a. (636 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
ENSHBUP00000010708Rpn3_C domain-containing protein. (104 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
mcm6DNA helicase; Belongs to the MCM family. (828 aa)
mcm3DNA helicase; Belongs to the MCM family. (811 aa)
ENSHBUP00000009952PH domain-containing protein. (146 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (619 aa)
LOC102292095Si:ch211-269e2.1. (1091 aa)
LOC102310266RAD21 cohesin complex component like 1. (547 aa)
anapc10Anaphase promoting complex subunit 10. (143 aa)
LOC102299877Proteasome subunit beta. (275 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (481 aa)
LOC102300798Proteasome subunit beta 12. (226 aa)
LOC102300494Proteasome subunit beta. (216 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
orc5Origin recognition complex, subunit 5. (450 aa)
bicraBRD4 interacting chromatin remodeling complex associated protein. (1775 aa)
ccnhCyclin H; Belongs to the cyclin family. (335 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
LOC102297270SCY domain-containing protein. (125 aa)
PSMD11PCI domain-containing protein. (422 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
psme4Proteasome activator subunit 4a. (1811 aa)
waplWAPL cohesin release factor a. (1171 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (498 aa)
psma4Proteasome subunit alpha type. (261 aa)
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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