STRINGSTRING
LOC102291663 LOC102291663 LOC102297056 LOC102297056 LOC102303940 LOC102303940 LOC102305030 LOC102305030 LOC102296557 LOC102296557 LOC106633073 LOC106633073 fgf16 fgf16 gab2 gab2 LOC102300549 LOC102300549 LOC102304289 LOC102304289 LOC102291222 LOC102291222 LOC102289294 LOC102289294 LOC102311744 LOC102311744 LOC102304610 LOC102304610 ins ins atp6v1c2 atp6v1c2 LOC102297549 LOC102297549 pde3b pde3b fgf20 fgf20 ATP6V0C ATP6V0C LOC102304410 LOC102304410 atp6v1g1 atp6v1g1 LOC102292008 LOC102292008 fgfr4 fgfr4 fgf8 fgf8 LOC102311290 LOC102311290 LOC102292195 LOC102292195 ENSHBUP00000034095 ENSHBUP00000034095 ENSHBUP00000034273 ENSHBUP00000034273 LOC102299313 LOC102299313 grb2 grb2 atp6v1c1 atp6v1c1 LOC102297192 LOC102297192 FGF6-2 FGF6-2 LOC102311977 LOC102311977 atp6v1h atp6v1h LOC102289393 LOC102289393 LOC102291452 LOC102291452 fgf22 fgf22 gab1 gab1 fgf18 fgf18 klb klb LOC102303523 LOC102303523 LOC102312030 LOC102312030 LOC102314346 LOC102314346 LOC102298882 LOC102298882 fgf5 fgf5 LOC102305144 LOC102305144 pdpk1 pdpk1 LOC102300439 LOC102300439 shc1 shc1 atp6v0e1 atp6v0e1 LOC102297386 LOC102297386 LOC102312034 LOC102312034 LOC102304321 LOC102304321 atp6v0a1 atp6v0a1 atp6ap1l atp6ap1l pik3cb pik3cb LOC102304742 LOC102304742 LOC102298187 LOC102298187 ENSHBUP00000019390 ENSHBUP00000019390 LOC102300764 LOC102300764 fgf2 fgf2 LOC102310436 LOC102310436 LOC102291075 LOC102291075 cnst cnst atp6v1d atp6v1d ATP6V1B2 ATP6V1B2 ATP6V0D2 ATP6V0D2 ENSHBUP00000015624 ENSHBUP00000015624 LOC102297589 LOC102297589 atp6v1a atp6v1a LOC102304563 LOC102304563 LOC102294406 LOC102294406 LOC102305199 LOC102305199 LOC102307281 LOC102307281 FGF13 FGF13 LOC102292514 LOC102292514 fgf19 fgf19 fgf4 fgf4 LOC102302326 LOC102302326 fgf3 fgf3 LOC102300437 LOC102300437 FGF6 FGF6 ptprf ptprf lctl lctl SHC4 SHC4 fgf7 fgf7 fgf10 fgf10 LOC102303372 LOC102303372 ENSHBUP00000009952 ENSHBUP00000009952 atp6v0b atp6v0b fgfr2 fgfr2 fgf23 fgf23 LOC102297885 LOC102297885 LOC102296117 LOC102296117 ENSHBUP00000006967 ENSHBUP00000006967 LOC102294416 LOC102294416 LOC102307790 LOC102307790 ENSHBUP00000005111 ENSHBUP00000005111 kl kl atp6v0a2 atp6v0a2 ENSHBUP00000003882 ENSHBUP00000003882 ENSHBUP00000003732 ENSHBUP00000003732 LOC102308504 LOC102308504 pik3ca pik3ca ENSHBUP00000003075 ENSHBUP00000003075 LOC102291974 LOC102291974
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC102291663Insulin-degrading enzyme; Belongs to the peptidase M16 family. (969 aa)
LOC102297056Lens intrinsic membrane protein 2.4. (173 aa)
LOC102303940Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
LOC102305030V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
LOC102296557Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
LOC106633073Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
gab2GRB2-associated binding protein 2. (654 aa)
LOC102300549Consortin, connexin sorting protein b. (364 aa)
LOC102304289Tyrosine-protein phosphatase non-receptor type. (386 aa)
LOC102291222Insulin receptor substrate 2b. (1160 aa)
LOC102289294Fibroblast growth factor receptor. (836 aa)
LOC102311744Tribbles pseudokinase 3. (353 aa)
LOC102304610Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
insInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (113 aa)
atp6v1c2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (361 aa)
LOC102297549Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (502 aa)
pde3bPhosphodiesterase. (1099 aa)
fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
LOC102304410Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
atp6v1g1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
LOC102292008Uncharacterized protein. (458 aa)
fgfr4Fibroblast growth factor receptor 4. (945 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
LOC102311290Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (594 aa)
LOC102292195V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (848 aa)
ENSHBUP00000034095Uncharacterized protein. (226 aa)
ENSHBUP00000034273Zgc:158659; Belongs to the PI3/PI4-kinase family. (485 aa)
LOC102299313Growth factor receptor-bound protein 10a. (597 aa)
grb2Growth factor receptor-bound protein 2b. (217 aa)
atp6v1c1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (383 aa)
LOC102297192Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
FGF6-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC102311977Uncharacterized protein. (174 aa)
atp6v1hV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (484 aa)
LOC102289393PH domain-containing protein. (543 aa)
LOC102291452Fibroblast growth factor receptor. (818 aa)
fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
gab1GRB2-associated binding protein 1. (746 aa)
fgf18Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
klbKlotho beta. (1049 aa)
LOC102303523Uncharacterized protein. (938 aa)
LOC102312030Fibroblast growth factor receptor substrate 2b. (525 aa)
LOC102314346Insulin receptor substrate 2a. (1086 aa)
LOC102298882Nardilysin a (N-arginine dibasic convertase); Belongs to the peptidase M16 family. (1093 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
LOC102305144Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (666 aa)
pdpk13-phosphoinositide dependent protein kinase 1b. (565 aa)
LOC102300439Thioesterase superfamily member 4. (249 aa)
shc1SHC (Src homology 2 domain containing) transforming protein 1. (600 aa)
atp6v0e1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
LOC102297386Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
LOC102312034Lens intrinsic membrane protein 2.3. (173 aa)
LOC102304321Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (129 aa)
atp6v0a1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (835 aa)
atp6ap1lATPase H+ transporting accessory protein 1 like a. (318 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
LOC102304742Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
LOC102298187Uncharacterized protein. (625 aa)
ENSHBUP00000019390Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (284 aa)
LOC102300764V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
LOC102310436Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
LOC102291075Fibroblast growth factor receptor. (709 aa)
cnstConsortin_C domain-containing protein. (844 aa)
atp6v1dATPase H+ transporting V1 subunit D. (248 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (520 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (355 aa)
ENSHBUP00000015624Uncharacterized protein. (51 aa)
LOC102297589Growth factor receptor-bound protein 10b. (620 aa)
atp6v1aATPase H+ transporting V1 subunit A. (617 aa)
LOC102304563V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
LOC102294406V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
LOC102305199ATPase H+ transporting V1 subunit E1a. (226 aa)
LOC102307281Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
LOC102292514Tyrosine-protein kinase receptor. (1365 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
LOC102302326Lactase-like a; Belongs to the glycosyl hydrolase 1 family. (574 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
LOC102300437Uncharacterized protein. (248 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ptprfProtein tyrosine phosphatase receptor type Fa. (1896 aa)
lctlLactase-like b; Belongs to the glycosyl hydrolase 1 family. (585 aa)
SHC4SHC adaptor protein 4. (588 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
LOC102303372Protein tyrosine phosphatase receptor type Fb. (1919 aa)
ENSHBUP00000009952PH domain-containing protein. (146 aa)
atp6v0bATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (211 aa)
fgfr2Fibroblast growth factor receptor. (835 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (255 aa)
LOC102297885ATPase H+ transporting V1 subunit E1b. (226 aa)
LOC102296117V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (824 aa)
ENSHBUP00000006967ATPase H+ transporting V1 subunit F. (79 aa)
LOC102294416ATPase H+ transporting accessory protein 1b. (448 aa)
LOC102307790ATPase H+ transporting accessory protein 1 like b. (341 aa)
ENSHBUP00000005111Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
klKlotho. (978 aa)
atp6v0a2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (849 aa)
ENSHBUP00000003882Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (441 aa)
ENSHBUP00000003732Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (373 aa)
LOC102308504Tyrosine-protein kinase receptor. (1375 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSHBUP00000003075Uncharacterized protein. (98 aa)
LOC102291974Insulin-degrading enzyme; Belongs to the peptidase M16 family. (978 aa)
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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