(30 nodes) Butanoate metabolism network (Haplochromis burtoni)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	ehhadh	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (719 aa)
	aacs	Acetoacetyl-CoA synthetase. (676 aa)
	LOC102308870	Zgc:113054. (551 aa)
	bdh2	3-hydroxybutyrate dehydrogenase, type 2. (245 aa)
	gad1	Glutamate decarboxylase 1a. (591 aa)
	LOC102292132	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (516 aa)
	gad2	Glutamate decarboxylase 2. (584 aa)
	acat2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (444 aa)
	ENSHBUP00000009549	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a. (758 aa)
	l2hgdh	L-2-hydroxyglutarate dehydrogenase. (430 aa)
	hmgcl	3-hydroxy-3-methylglutaryl-CoA lyase. (337 aa)
	LOC102309791	Zgc:101569; Belongs to the enoyl-CoA hydratase/isomerase family. (315 aa)
	LOC102299200	Uncharacterized protein. (126 aa)
	LOC102313844	Uncharacterized protein. (107 aa)
	oxct1	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (524 aa)
	hmgcll1	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. (341 aa)
	LOC102292090	Uncharacterized protein. (102 aa)
	acads	Acyl-CoA dehydrogenase short chain. (405 aa)
	LOC102308388	Uncharacterized protein. (112 aa)
	aldh5a1	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (514 aa)
	echs1	Enoyl CoA hydratase, short chain, 1, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (357 aa)
	abat	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
	LOC102300090	Uncharacterized protein. (558 aa)
	hadha	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
	acat1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
	GAD1	Glutamate decarboxylase 1b. (235 aa)
	GAD1-2	Uncharacterized protein. (213 aa)
	LOC102298252	3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (361 aa)
	hadh	Uncharacterized protein. (309 aa)
	LOC102294559	Zgc:113142. (381 aa)

Your Current Organism:

Haplochromis burtoni

NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHBUP00000009549	LOC102292090	ENSHBUP00000009549	ENSHBUP00000004425	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Uncharacterized protein.	0.873
ENSHBUP00000009549	LOC102292132	ENSHBUP00000009549	ENSHBUP00000025200	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.858
ENSHBUP00000009549	LOC102299200	ENSHBUP00000009549	ENSHBUP00000022489	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Uncharacterized protein.	0.902
ENSHBUP00000009549	LOC102308388	ENSHBUP00000009549	ENSHBUP00000006706	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Uncharacterized protein.	0.873
ENSHBUP00000009549	LOC102308870	ENSHBUP00000009549	ENSHBUP00000027344	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Zgc:113054.	0.661
ENSHBUP00000009549	LOC102309791	ENSHBUP00000009549	ENSHBUP00000021080	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Zgc:101569; Belongs to the enoyl-CoA hydratase/isomerase family.	0.848
ENSHBUP00000009549	LOC102313844	ENSHBUP00000009549	ENSHBUP00000028862	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Uncharacterized protein.	0.873
ENSHBUP00000009549	aacs	ENSHBUP00000009549	ENSHBUP00000027561	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Acetoacetyl-CoA synthetase.	0.675
ENSHBUP00000009549	abat	ENSHBUP00000009549	ENSHBUP00000032808	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.815
ENSHBUP00000009549	acads	ENSHBUP00000009549	ENSHBUP00000006530	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Acyl-CoA dehydrogenase short chain.	0.935
ENSHBUP00000009549	acat1	ENSHBUP00000009549	ENSHBUP00000006165	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.956
ENSHBUP00000009549	acat2	ENSHBUP00000009549	ENSHBUP00000012096	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.956
ENSHBUP00000009549	aldh5a1	ENSHBUP00000009549	ENSHBUP00000007304	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.548
ENSHBUP00000009549	bdh2	ENSHBUP00000009549	ENSHBUP00000026606	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	3-hydroxybutyrate dehydrogenase, type 2.	0.661
ENSHBUP00000009549	echs1	ENSHBUP00000009549	ENSHBUP00000034749	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Enoyl CoA hydratase, short chain, 1, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family.	0.927
ENSHBUP00000009549	ehhadh	ENSHBUP00000009549	ENSHBUP00000022665	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.858
ENSHBUP00000009549	hadh	ENSHBUP00000009549	ENSHBUP00000030712	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Uncharacterized protein.	0.918
ENSHBUP00000009549	hadha	ENSHBUP00000009549	ENSHBUP00000031441	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	0.887
ENSHBUP00000009549	hmgcl	ENSHBUP00000009549	ENSHBUP00000018036	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.780
ENSHBUP00000009549	hmgcll1	ENSHBUP00000009549	ENSHBUP00000025085	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1.	0.780