STRINGSTRING
pif1 pif1 dmc1 dmc1 atrx atrx CNP CNP helq helq abraxas1 abraxas1 bard1 bard1 n4bp2 n4bp2 ENSHBUP00000002926 ENSHBUP00000002926 brca1 brca1 LOC102294519 LOC102294519 babam1 babam1 xrcc3 xrcc3 brip1 brip1 ENSHBUP00000005048 ENSHBUP00000005048 ENSHBUP00000005062 ENSHBUP00000005062 ENSHBUP00000005490 ENSHBUP00000005490 sass6 sass6 rad54l rad54l ssbp1 ssbp1 LOC102307530 LOC102307530 mcfd2 mcfd2 pold3 pold3 RPA1 RPA1 ENSHBUP00000008246 ENSHBUP00000008246 slf1 slf1 ENSHBUP00000009123 ENSHBUP00000009123 ENSHBUP00000009143 ENSHBUP00000009143 pold2 pold2 mus81 mus81 ppil3 ppil3 uimc1 uimc1 knl1 knl1 LOC102292855 LOC102292855 babam2 babam2 sap130 sap130 ENSHBUP00000011390 ENSHBUP00000011390 unc93a unc93a topbp1 topbp1 ENSHBUP00000013671 ENSHBUP00000013671 blm blm rad54b rad54b pold4 pold4 abraxas2 abraxas2 top3a top3a pold1 pold1 LOC102305895 LOC102305895 meiob meiob SUGP1 SUGP1 mcph1 mcph1 stn1 stn1 LOC102295570 LOC102295570 brca2 brca2 rad50 rad50 nbn nbn ficd ficd PTGDR2 PTGDR2 sycp3 sycp3 rad51 rad51 ENSHBUP00000025640 ENSHBUP00000025640 yju2 yju2 rpa2 rpa2 xrcc2 xrcc2 ENSHBUP00000027528 ENSHBUP00000027528 ENSHBUP00000028115 ENSHBUP00000028115 ENSHBUP00000028273 ENSHBUP00000028273 MPHOSPH9 MPHOSPH9 unc93b1 unc93b1 slc4a1ap slc4a1ap prkrip1 prkrip1 ENSHBUP00000029115 ENSHBUP00000029115 rad51d rad51d rpa3 rpa3 palb2 palb2 rbbp8 rbbp8 ddx52 ddx52 pithd1 pithd1 rpa1 rpa1 mre11 mre11 sem1 sem1 recql4 recql4 rtel1 rtel1 eme1 eme1 LOC102306769 LOC102306769 LOC102297614 LOC102297614 ENSHBUP00000034351 ENSHBUP00000034351 LOC102296147 LOC102296147
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (632 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
atrxATRX chromatin remodeler. (1871 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (633 aa)
helqHelicase, POLQ like. (995 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (346 aa)
bard1BRCA1 associated RING domain 1. (813 aa)
n4bp2NEDD4 binding protein 2. (1814 aa)
ENSHBUP00000002926ATRX chromatin remodeler, like. (1369 aa)
brca1Uncharacterized protein. (1388 aa)
LOC102294519Si:ch211-125a15.1. (448 aa)
babam1BRISC and BRCA1 A complex member 1. (378 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (336 aa)
brip1BRCA1 interacting protein C-terminal helicase 1. (1221 aa)
ENSHBUP00000005048TAN domain-containing protein. (177 aa)
ENSHBUP00000005062Uncharacterized protein. (143 aa)
ENSHBUP00000005490Reverse transcriptase domain-containing protein. (348 aa)
sass6SAS-6 centriolar assembly protein. (588 aa)
rad54lRAD54 like. (739 aa)
ssbp1Single-stranded DNA binding protein 1. (147 aa)
LOC102307530Src homology 2 domain containing transforming protein D, a. (406 aa)
mcfd2Multiple coagulation factor deficiency 2. (153 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (444 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
ENSHBUP00000008246Uncharacterized protein. (117 aa)
slf1SMC5-SMC6 complex localization factor 1. (885 aa)
ENSHBUP00000009123Uncharacterized protein. (264 aa)
ENSHBUP00000009143AAA_23 domain-containing protein. (92 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (481 aa)
mus81MUS81 structure-specific endonuclease subunit. (650 aa)
ppil3Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (170 aa)
uimc1RAP80_UIM domain-containing protein. (848 aa)
knl1Knl1_RWD_C domain-containing protein. (1829 aa)
LOC102292855G_PROTEIN_RECEP_F1_2 domain-containing protein. (448 aa)
babam2BRISC and BRCA1 A complex member 2. (400 aa)
sap130Sin3A-associated protein a. (1053 aa)
ENSHBUP00000011390BRCA1/BRCA2-containing complex, subunit 3. (266 aa)
unc93aUnc-93 homolog A. (464 aa)
topbp1DNA topoisomerase II binding protein 1. (1538 aa)
ENSHBUP00000013671Reverse transcriptase domain-containing protein. (397 aa)
blmBLM RecQ like helicase. (1405 aa)
rad54bRAD54 homolog B. (935 aa)
pold4Si:dkey-28b4.7. (107 aa)
abraxas2Abraxas 2, BRISC complex subunit. (453 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa)
pold1DNA polymerase. (1129 aa)
LOC102305895Uncharacterized protein. (298 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
SUGP1SURP and G-patch domain containing 1. (638 aa)
mcph1Microcephalin 1. (771 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (365 aa)
LOC102295570Uncharacterized protein. (505 aa)
brca2BRCA2 DNA repair associated. (3303 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
nbnNibrin. (779 aa)
ficdFIC domain containing. (450 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (361 aa)
sycp3Synaptonemal complex protein 3. (288 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
ENSHBUP00000025640Reverse transcriptase domain-containing protein. (416 aa)
yju2YJU2 splicing factor homolog. (340 aa)
rpa2Replication protein A2. (293 aa)
xrcc2X-ray repair cross complementing 2. (324 aa)
ENSHBUP00000027528Uncharacterized protein. (252 aa)
ENSHBUP00000028115Reverse transcriptase domain-containing protein. (365 aa)
ENSHBUP00000028273Uncharacterized protein. (107 aa)
MPHOSPH9M-phase phosphoprotein 9. (1111 aa)
unc93b1Unc-93 homolog B1, TLR signaling regulator. (624 aa)
slc4a1apSolute carrier family 4 member 1 adaptor protein. (706 aa)
prkrip1PRKR interacting protein 1. (193 aa)
ENSHBUP00000029115Uncharacterized protein. (166 aa)
rad51dRAD51 paralog D. (333 aa)
rpa3Replication protein A3. (122 aa)
palb2PALB2_WD40 domain-containing protein. (1356 aa)
rbbp8Uncharacterized protein. (673 aa)
ddx52DEAD (Asp-Glu-Ala-Asp) box polypeptide 52. (679 aa)
pithd1PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1. (209 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (695 aa)
sem1SEM1 26S proteasome complex subunit. (70 aa)
recql4RecQ helicase-like 4. (1577 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1137 aa)
eme1Essential meiotic structure-specific endonuclease 1. (526 aa)
LOC102306769ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (817 aa)
LOC102297614RAD51 paralog C. (359 aa)
ENSHBUP00000034351DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (138 aa)
LOC102296147Leucine rich adaptor protein 1. (363 aa)
Your Current Organism:
Haplochromis burtoni
NCBI taxonomy Id: 8153
Other names: Astatotilapia burtoni, Chromis burtoni, H. burtoni
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