(25 nodes) Clathrin coat network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	clta	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (232 aa)
	LOC113027676	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (927 aa)
	ENSACLP00000002719	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1619 aa)
	ENSACLP00000002940	DnaJ (Hsp40) homolog, subfamily C, member 6. (923 aa)
	ENSACLP00000003396	AP-1 complex subunit gamma. (820 aa)
	cltb	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (235 aa)
	ENSACLP00000009309	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (434 aa)
	ENSACLP00000012873	SH3 domain-containing protein. (69 aa)
	epn2	Epsin 2. (576 aa)
	ENSACLP00000014175	Intersectin 2b. (1549 aa)
	cltcl1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1685 aa)
	ENSACLP00000015691	Epidermal growth factor receptor pathway substrate 15 like 1. (442 aa)
	ENSACLP00000016469	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (920 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
	gak	Cyclin G associated kinase. (1317 aa)
	eps15l1	Epidermal growth factor receptor pathway substrate 15-like 1a. (968 aa)
	LOC113030513	AP complex subunit beta. (953 aa)
	necap2	NECAP endocytosis associated 2. (255 aa)
	LOC113032146	Epsin 1. (648 aa)
	LOC113032223	DUF1681 domain-containing protein. (274 aa)
	ENSACLP00000034114	Epsin 3a. (599 aa)
	ENSACLP00000034552	Epidermal growth factor receptor pathway substrate 15. (1036 aa)
	LOC113033372	Huntingtin interacting protein 1 related b. (1079 aa)
	ap1b1	AP complex subunit beta. (1001 aa)
	ENSACLP00000038202	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1686 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000002719	ENSACLP00000002940	ENSACLP00000002719	ENSACLP00000002940	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	DnaJ (Hsp40) homolog, subfamily C, member 6.	0.998
ENSACLP00000002719	ENSACLP00000003396	ENSACLP00000002719	ENSACLP00000003396	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-1 complex subunit gamma.	0.938
ENSACLP00000002719	ENSACLP00000009309	ENSACLP00000002719	ENSACLP00000009309	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.943
ENSACLP00000002719	ENSACLP00000012873	ENSACLP00000002719	ENSACLP00000012873	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	SH3 domain-containing protein.	0.993
ENSACLP00000002719	ENSACLP00000014175	ENSACLP00000002719	ENSACLP00000014175	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Intersectin 2b.	0.993
ENSACLP00000002719	ENSACLP00000015691	ENSACLP00000002719	ENSACLP00000015691	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Epidermal growth factor receptor pathway substrate 15 like 1.	0.841
ENSACLP00000002719	ENSACLP00000016469	ENSACLP00000002719	ENSACLP00000016469	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.955
ENSACLP00000002719	ENSACLP00000034114	ENSACLP00000002719	ENSACLP00000034114	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Epsin 3a.	0.871
ENSACLP00000002719	ENSACLP00000034552	ENSACLP00000002719	ENSACLP00000034552	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Epidermal growth factor receptor pathway substrate 15.	0.841
ENSACLP00000002719	LOC113027676	ENSACLP00000002719	ENSACLP00000000978	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.923
ENSACLP00000002719	LOC113030513	ENSACLP00000002719	ENSACLP00000031510	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP complex subunit beta.	0.961
ENSACLP00000002719	LOC113032146	ENSACLP00000002719	ENSACLP00000033201	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Epsin 1.	0.871
ENSACLP00000002719	LOC113032223	ENSACLP00000002719	ENSACLP00000033365	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	DUF1681 domain-containing protein.	0.616
ENSACLP00000002719	LOC113033372	ENSACLP00000002719	ENSACLP00000035105	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Huntingtin interacting protein 1 related b.	0.909
ENSACLP00000002719	ap1b1	ENSACLP00000002719	ENSACLP00000037493	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP complex subunit beta.	0.961
ENSACLP00000002719	ap2s1	ENSACLP00000002719	ENSACLP00000025890	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.928
ENSACLP00000002719	clta	ENSACLP00000002719	ENSACLP00000000558	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.973
ENSACLP00000002719	cltb	ENSACLP00000002719	ENSACLP00000005219	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.973
ENSACLP00000002719	epn2	ENSACLP00000002719	ENSACLP00000013355	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Epsin 2.	0.914
ENSACLP00000002719	eps15l1	ENSACLP00000002719	ENSACLP00000029254	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Epidermal growth factor receptor pathway substrate 15-like 1a.	0.841