(42 nodes) Mixed, incl. Bcl-2-like superfamily, and Pyroptosis network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113029596	Zgc:153993. (274 aa)
	LOC113015255	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (113 aa)
	LOC113015033	Uncharacterized protein. (203 aa)
	bmf	Uncharacterized protein. (170 aa)
	siva1	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (164 aa)
	ENSACLP00000005540	CARD domain-containing protein. (108 aa)
	bax	Uncharacterized protein. (205 aa)
	ENSACLP00000006475	Uncharacterized protein. (165 aa)
	ENSACLP00000006599	MCL1 apoptosis regulator, BCL2 family member b. (278 aa)
	ENSACLP00000007875	CARD domain-containing protein. (106 aa)
	bcl2l1	BCL2 like 1. (233 aa)
	ENSACLP00000010490	Uncharacterized protein. (185 aa)
	nr4a3	Nuclear receptor subfamily 4, group A, member 3. (611 aa)
	ENSACLP00000011675	CARD domain-containing protein. (103 aa)
	LOC113007820	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (121 aa)
	ENSACLP00000013895	CARD domain-containing protein. (119 aa)
	ENSACLP00000014692	CARD domain-containing protein. (119 aa)
	LOC113021474	Uncharacterized protein. (223 aa)
	LOC113021474-2	Apoptosis regulator BAX-like. (223 aa)
	WDSUB1	WD repeat, sterile alpha motif and U-box domain containing 1. (485 aa)
	nr4a2	Nuclear receptor subfamily 4, group A, member 2b. (600 aa)
	ENSACLP00000021231	BCL2 like 10. (273 aa)
	ENSACLP00000025076	Ig-like domain-containing protein. (207 aa)
	LOC113029594	BH4_2 domain-containing protein. (198 aa)
	ENSACLP00000028321	Uncharacterized protein. (149 aa)
	ENSACLP00000031605	Uncharacterized protein. (251 aa)
	bad	BCL2 associated agonist of cell death b. (158 aa)
	apaf1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1258 aa)
	ENSACLP00000033052	CARD domain-containing protein. (102 aa)
	bcl2	BCL2 apoptosis regulator b. (228 aa)
	LOC113016700	BCL2 family apoptosis regulator BOK a. (210 aa)
	aven	Apoptosis, caspase activation inhibitor. (328 aa)
	LOC113029402	Cystatin domain-containing protein; Belongs to the cystatin family. (99 aa)
	ENSACLP00000039887	Cystatin domain-containing protein. (128 aa)
	LOC113029022	Cystatin domain-containing protein; Belongs to the cystatin family. (154 aa)
	ENSACLP00000039916	Cystatin domain-containing protein. (96 aa)
	ENSACLP00000039966	annotation not available (96 aa)
	LOC113029730	Cystatin domain-containing protein. (149 aa)
	LOC113029732	Cystatin domain-containing protein. (99 aa)
	LOC113035255	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	LOC113035255-2	Cytochrome c. (104 aa)
	ENSACLP00000040929	Ig-like domain-containing protein. (201 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000005540	ENSACLP00000039887	ENSACLP00000005540	ENSACLP00000039887	CARD domain-containing protein.	Cystatin domain-containing protein.	0.414
ENSACLP00000005540	ENSACLP00000039916	ENSACLP00000005540	ENSACLP00000039916	CARD domain-containing protein.	Cystatin domain-containing protein.	0.414
ENSACLP00000005540	ENSACLP00000039966	ENSACLP00000005540	ENSACLP00000039966	CARD domain-containing protein.	annotation not available	0.414
ENSACLP00000005540	LOC113029022	ENSACLP00000005540	ENSACLP00000039901	CARD domain-containing protein.	Cystatin domain-containing protein; Belongs to the cystatin family.	0.414
ENSACLP00000005540	LOC113029402	ENSACLP00000005540	ENSACLP00000039881	CARD domain-containing protein.	Cystatin domain-containing protein; Belongs to the cystatin family.	0.414
ENSACLP00000005540	LOC113029594	ENSACLP00000005540	ENSACLP00000025580	CARD domain-containing protein.	BH4_2 domain-containing protein.	0.609
ENSACLP00000005540	LOC113029730	ENSACLP00000005540	ENSACLP00000039982	CARD domain-containing protein.	Cystatin domain-containing protein.	0.414
ENSACLP00000005540	LOC113029732	ENSACLP00000005540	ENSACLP00000039993	CARD domain-containing protein.	Cystatin domain-containing protein.	0.414
ENSACLP00000005540	apaf1	ENSACLP00000005540	ENSACLP00000032714	CARD domain-containing protein.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.803
ENSACLP00000005540	bcl2	ENSACLP00000005540	ENSACLP00000033164	CARD domain-containing protein.	BCL2 apoptosis regulator b.	0.609
ENSACLP00000005540	bcl2l1	ENSACLP00000005540	ENSACLP00000010478	CARD domain-containing protein.	BCL2 like 1.	0.615
ENSACLP00000006475	ENSACLP00000006599	ENSACLP00000006475	ENSACLP00000006599	Uncharacterized protein.	MCL1 apoptosis regulator, BCL2 family member b.	0.978
ENSACLP00000006475	ENSACLP00000039887	ENSACLP00000006475	ENSACLP00000039887	Uncharacterized protein.	Cystatin domain-containing protein.	0.455
ENSACLP00000006475	ENSACLP00000039916	ENSACLP00000006475	ENSACLP00000039916	Uncharacterized protein.	Cystatin domain-containing protein.	0.455
ENSACLP00000006475	ENSACLP00000039966	ENSACLP00000006475	ENSACLP00000039966	Uncharacterized protein.	annotation not available	0.455
ENSACLP00000006475	LOC113007820	ENSACLP00000006475	ENSACLP00000012331	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.894
ENSACLP00000006475	LOC113015033	ENSACLP00000006475	ENSACLP00000001206	Uncharacterized protein.	Uncharacterized protein.	0.606
ENSACLP00000006475	LOC113015255	ENSACLP00000006475	ENSACLP00000001199	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.894
ENSACLP00000006475	LOC113029022	ENSACLP00000006475	ENSACLP00000039901	Uncharacterized protein.	Cystatin domain-containing protein; Belongs to the cystatin family.	0.455
ENSACLP00000006475	LOC113029402	ENSACLP00000006475	ENSACLP00000039881	Uncharacterized protein.	Cystatin domain-containing protein; Belongs to the cystatin family.	0.455