STRINGSTRING
msh6 msh6 ENSACLP00000000444 ENSACLP00000000444 exd2 exd2 ENSACLP00000000986 ENSACLP00000000986 chtf18 chtf18 pole3 pole3 rad9b rad9b rev1 rev1 rfc4 rfc4 ENSACLP00000001994 ENSACLP00000001994 ENSACLP00000003108 ENSACLP00000003108 nars1 nars1 LOC113016318 LOC113016318 fancg fancg ENSACLP00000003814 ENSACLP00000003814 rfwd3 rfwd3 pole4 pole4 pms1 pms1 pold3 pold3 RTEL1 RTEL1 ENSACLP00000005074 ENSACLP00000005074 atrip atrip rfc3 rfc3 lig1 lig1 fbh1 fbh1 polk polk ENSACLP00000007188 ENSACLP00000007188 ENSACLP00000007406 ENSACLP00000007406 CLSPN CLSPN RPA1 RPA1 rad1 rad1 hltf hltf rmi2 rmi2 ENSACLP00000008384 ENSACLP00000008384 top3b top3b ENSACLP00000008753 ENSACLP00000008753 ENSACLP00000008921 ENSACLP00000008921 ENSACLP00000009181 ENSACLP00000009181 ENSACLP00000009352 ENSACLP00000009352 ENSACLP00000009703 ENSACLP00000009703 ENSACLP00000009741 ENSACLP00000009741 ENSACLP00000009814 ENSACLP00000009814 ENSACLP00000010589 ENSACLP00000010589 ENSACLP00000010605 ENSACLP00000010605 ENSACLP00000011020 ENSACLP00000011020 ENSACLP00000011862 ENSACLP00000011862 ENSACLP00000011868 ENSACLP00000011868 ankrd12 ankrd12 ube2t ube2t recql5 recql5 dna2 dna2 ENSACLP00000012686 ENSACLP00000012686 ENSACLP00000012793 ENSACLP00000012793 wdhd1 wdhd1 ENSACLP00000013446 ENSACLP00000013446 ENSACLP00000013582 ENSACLP00000013582 ENSACLP00000013892 ENSACLP00000013892 ENSACLP00000013990 ENSACLP00000013990 rad50 rad50 EME2 EME2 rfc2 rfc2 fancf fancf pcna pcna recql4 recql4 ENSACLP00000017593 ENSACLP00000017593 msh3 msh3 ifih1 ifih1 dscc1 dscc1 ENSACLP00000020445 ENSACLP00000020445 CENPS CENPS rad9a rad9a rbbp8 rbbp8 ENSACLP00000020901 ENSACLP00000020901 LOC113013471 LOC113013471 ENSACLP00000021167 ENSACLP00000021167 LOC113009323 LOC113009323 FAAP100 FAAP100 top3a top3a ENSACLP00000021854 ENSACLP00000021854 pms2 pms2 LOC113015000 LOC113015000 ENSACLP00000022421 ENSACLP00000022421 rfc1 rfc1 rpa3 rpa3 fancm fancm SMARCAL1 SMARCAL1 meiob meiob ENSACLP00000025028 ENSACLP00000025028 ENSACLP00000025034 ENSACLP00000025034 ENSACLP00000025050 ENSACLP00000025050 mad2l2 mad2l2 ercc4 ercc4 xrcc3 xrcc3 rad17 rad17 chtf8 chtf8 ercc1 ercc1 XRCC2 XRCC2 nbn nbn mus81 mus81 dmc1 dmc1 ENSACLP00000026746 ENSACLP00000026746 rmi1 rmi1 zdhhc16 zdhhc16 pold4 pold4 hus1 hus1 mre11 mre11 LOC113008023 LOC113008023 rev3l rev3l ENSACLP00000027714 ENSACLP00000027714 rhno1 rhno1 fen1 fen1 gen1 gen1 blm blm wrnip1 wrnip1 poli poli primpol primpol rad51 rad51 brip1 brip1 nutf2 nutf2 ENSACLP00000031218 ENSACLP00000031218 cdca7l cdca7l ENSACLP00000033842 ENSACLP00000033842 tdrd3 tdrd3 ENSACLP00000034214 ENSACLP00000034214 ENSACLP00000034298 ENSACLP00000034298 rfc5 rfc5 rad18 rad18 faap24 faap24 rad51d rad51d ENSACLP00000035598 ENSACLP00000035598 ercc5 ercc5 ENSACLP00000036091 ENSACLP00000036091 eme1 eme1 ENSACLP00000036837 ENSACLP00000036837 slx4 slx4 ankrd11 ankrd11 mdc1 mdc1 cenpx cenpx rad52 rad52 zranb3 zranb3 ENSACLP00000040663 ENSACLP00000040663 fanci fanci rpa2 rpa2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1441 aa)
ENSACLP00000000444Uncharacterized protein. (1863 aa)
exd2Exonuclease 3'-5' domain containing 2. (640 aa)
ENSACLP00000000986DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2036 aa)
chtf18AAA domain-containing protein. (922 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
rad9bRAD9 checkpoint clamp component B. (390 aa)
rev1REV1 DNA directed polymerase. (1390 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
ENSACLP00000001994ATPase family AAA domain containing 5a. (1510 aa)
ENSACLP00000003108DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (917 aa)
nars1Asparaginyl-tRNA synthetase. (559 aa)
LOC113016318SCY domain-containing protein. (125 aa)
fancgFA complementation group G. (622 aa)
ENSACLP00000003814DEXH (Asp-Glu-X-His) box polypeptide 58. (677 aa)
rfwd3Ring finger and WD repeat domain 3. (707 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
pms1PMS1 homolog 1, mismatch repair system component. (897 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (443 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1123 aa)
ENSACLP00000005074Reverse transcriptase domain-containing protein. (484 aa)
atripUncharacterized protein. (795 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
lig1DNA ligase. (1014 aa)
fbh1F-box DNA helicase 1. (1077 aa)
polkPolymerase (DNA directed) kappa. (875 aa)
ENSACLP00000007188DNA topoisomerase II binding protein 1. (1484 aa)
ENSACLP00000007406Exonuclease 1. (775 aa)
CLSPNClaspin. (1037 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (640 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
hltfHelicase-like transcription factor. (1001 aa)
rmi2RecQ mediated genome instability 2. (146 aa)
ENSACLP00000008384ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2524 aa)
top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (856 aa)
ENSACLP00000008753Uncharacterized protein. (436 aa)
ENSACLP00000008921BRCT domain-containing protein. (641 aa)
ENSACLP00000009181SLX1 homolog B, structure-specific endonuclease subunit. (151 aa)
ENSACLP00000009352SMC5-SMC6 complex localization factor 1. (723 aa)
ENSACLP00000009703Fanconi_A_N domain-containing protein. (1279 aa)
ENSACLP00000009741Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
ENSACLP00000009814AAA domain-containing protein. (866 aa)
ENSACLP00000010589Tumor protein p53 binding protein, 1. (1505 aa)
ENSACLP00000010605DNA polymerase. (1128 aa)
ENSACLP00000011020Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (383 aa)
ENSACLP00000011862MutS homolog 5. (525 aa)
ENSACLP00000011868Uncharacterized protein. (133 aa)
ankrd12Ankyrin repeat domain 12. (1950 aa)
ube2tUbiquitin-conjugating enzyme E2T (putative). (202 aa)
recql5RecQ helicase-like 5. (1018 aa)
dna2DNA replication helicase/nuclease 2. (1417 aa)
ENSACLP00000012686Zinc-hook domain-containing protein. (1074 aa)
ENSACLP00000012793Reverse transcriptase domain-containing protein. (457 aa)
wdhd1WD repeat and HMG-box DNA binding protein 1. (1134 aa)
ENSACLP00000013446Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1109 aa)
ENSACLP00000013582Uncharacterized protein. (1377 aa)
ENSACLP00000013892Zgc:110269. (354 aa)
ENSACLP00000013990Cell division cycle associated 7a. (468 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
EME2ERCC4 domain-containing protein. (462 aa)
rfc2Replication factor C (activator 1) 2. (356 aa)
fancfFA complementation group F. (343 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
recql4RecQ helicase-like 4. (1577 aa)
ENSACLP00000017593Polymerase (DNA directed), delta 2, regulatory subunit. (482 aa)
msh3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1115 aa)
ifih1Interferon induced with helicase C domain 1. (992 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
ENSACLP00000020445FA complementation group L. (337 aa)
CENPSCentromere protein S. (146 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa)
rbbp8Uncharacterized protein. (670 aa)
ENSACLP00000020901DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (499 aa)
LOC113013471RAD51 paralog C. (359 aa)
ENSACLP00000021167Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (163 aa)
LOC113009323Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
FAAP100FA core complex associated protein 100. (866 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1044 aa)
ENSACLP00000021854Reverse transcriptase domain-containing protein. (530 aa)
pms2PMS1 homolog 2, mismatch repair system component. (861 aa)
LOC113015000NTF2 domain-containing protein. (130 aa)
ENSACLP00000022421FA complementation group C. (497 aa)
rfc1Replication factor C subunit 1. (1161 aa)
rpa3Replication protein A3. (122 aa)
fancmUncharacterized protein. (2085 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (899 aa)
meiobMethionine sulfoxide reductase B1b. (567 aa)
ENSACLP00000025028AAA_23 domain-containing protein. (53 aa)
ENSACLP00000025034Uncharacterized protein. (116 aa)
ENSACLP00000025050Uncharacterized protein. (255 aa)
mad2l2Mitotic arrest deficient 2 like 2. (210 aa)
ercc4Excision repair cross-complementation group 4. (899 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (357 aa)
rad17RAD17 checkpoint clamp loader component. (630 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (136 aa)
ercc1Excision repair cross-complementation group 1. (352 aa)
XRCC2X-ray repair cross complementing 2. (302 aa)
nbnNibrin. (843 aa)
mus81MUS81 structure-specific endonuclease subunit. (650 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
ENSACLP00000026746Reverse transcriptase domain-containing protein. (693 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (679 aa)
zdhhc16Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (366 aa)
pold4Si:dkey-28b4.7. (121 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
LOC113008023BRCA1 associated RING domain 1. (813 aa)
rev3lREV3 like, DNA directed polymerase zeta catalytic subunit. (3016 aa)
ENSACLP00000027714Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (385 aa)
rhno1Uncharacterized protein. (295 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa)
gen1Uncharacterized protein. (893 aa)
blmBLM RecQ like helicase. (1392 aa)
wrnip1WRN helicase interacting protein 1. (603 aa)
poliPolymerase (DNA directed) iota. (720 aa)
primpolPrimase and polymerase (DNA-directed). (548 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
brip1BRCA1 interacting protein C-terminal helicase 1. (1223 aa)
nutf2Nuclear transport factor 2. (127 aa)
ENSACLP00000031218MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (735 aa)
cdca7lCell division cycle associated 7b. (410 aa)
ENSACLP00000033842DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (871 aa)
tdrd3Tudor domain containing 3. (780 aa)
ENSACLP00000034214DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11. (860 aa)
ENSACLP00000034298Reverse transcriptase domain-containing protein. (457 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
rad18RAD18 E3 ubiquitin protein ligase. (493 aa)
faap24FA core complex associated protein 24. (216 aa)
rad51dRAD51 paralog D. (333 aa)
ENSACLP00000035598FA complementation group D2. (1416 aa)
ercc5Excision repair cross-complementation group 5. (1115 aa)
ENSACLP00000036091MutL homolog 3 (E. coli). (1171 aa)
eme1Essential meiotic structure-specific endonuclease 1. (550 aa)
ENSACLP00000036837Uncharacterized protein. (101 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1727 aa)
ankrd11Ankyrin repeat domain 11. (2848 aa)
mdc1Uncharacterized protein. (2074 aa)
cenpxCentromere protein X. (81 aa)
rad52RAD52 homolog, DNA repair protein. (417 aa)
zranb3Zinc finger, RAN-binding domain containing 3. (1156 aa)
ENSACLP00000040663Reverse transcriptase domain-containing protein. (474 aa)
fanciFA complementation group I. (1325 aa)
rpa2Replication protein A2. (293 aa)
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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