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ampd3 ampd3 LOC113013053 LOC113013053 ak4 ak4 NT5C3B NT5C3B adss1 adss1 gmps gmps LOC113022115 LOC113022115 nt5c3a nt5c3a LOC113011833 LOC113011833 ak7 ak7 LOC113034694 LOC113034694 LOC113024511 LOC113024511 LOC113036414 LOC113036414 ENSACLP00000008350 ENSACLP00000008350 ENSACLP00000009108 ENSACLP00000009108 ak5 ak5 aprt aprt LOC113024575 LOC113024575 adk adk adal adal ENSACLP00000012569 ENSACLP00000012569 ak8 ak8 ENSACLP00000013221 ENSACLP00000013221 NT5C3B-2 NT5C3B-2 ak1 ak1 LOC113030808 LOC113030808 ENSACLP00000016813 ENSACLP00000016813 ENSACLP00000017004 ENSACLP00000017004 ENSACLP00000017042 ENSACLP00000017042 ENSACLP00000017095 ENSACLP00000017095 ENSACLP00000017130 ENSACLP00000017130 LOC113018890 LOC113018890 LOC113014382 LOC113014382 ENSACLP00000019526 ENSACLP00000019526 pde1a pde1a LOC113015949 LOC113015949 ENSACLP00000022352 ENSACLP00000022352 gmpr gmpr ak9 ak9 ada ada ak6 ak6 pde1b pde1b ENSACLP00000027113 ENSACLP00000027113 ENSACLP00000027173 ENSACLP00000027173 ENSACLP00000027349 ENSACLP00000027349 impdh2 impdh2 LOC113025818 LOC113025818 ENSACLP00000028199 ENSACLP00000028199 LOC113023773 LOC113023773 LOC113009342 LOC113009342 atic atic NT5M NT5M ak2 ak2 ak3 ak3 LOC113026360 LOC113026360 LOC113008706 LOC113008706 LOC113009906 LOC113009906 LOC113006858 LOC113006858 LOC113034691 LOC113034691 LOC113022492 LOC113022492 hprt1 hprt1 LOC113006691 LOC113006691 ENSACLP00000036302 ENSACLP00000036302 gart gart LOC113026882 LOC113026882 cant1 cant1 ENSACLP00000038676 ENSACLP00000038676 LOC113026921 LOC113026921 LOC113006394 LOC113006394 ENSACLP00000041593 ENSACLP00000041593 ENSACLP00000041596 ENSACLP00000041596 ENSACLP00000041597 ENSACLP00000041597
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ampd3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (770 aa)
LOC113013053AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (830 aa)
ak4GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (226 aa)
NT5C3B5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (258 aa)
adss1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
gmpsGuanine monophosphate synthase. (690 aa)
LOC113022115Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (296 aa)
nt5c3a5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa)
LOC1130118335'-nucleotidase, cytosolic IAb. (371 aa)
ak7Adenylate kinase 7b. (692 aa)
LOC1130346945'-nucleotidase, cytosolic IIa. (558 aa)
LOC113024511Phosphodiesterase. (905 aa)
LOC113036414Zgc:174895. (200 aa)
ENSACLP00000008350Uncharacterized protein. (280 aa)
ENSACLP00000009108Adenosine kinase a. (208 aa)
ak5Adenylate kinase 5; Belongs to the adenylate kinase family. (564 aa)
aprtAdenine phosphoribosyltransferase. (181 aa)
LOC113024575Uncharacterized protein. (273 aa)
adkAdenosine kinase b. (357 aa)
adalAdenosine deaminase-like. (346 aa)
ENSACLP00000012569Phosphodiesterase. (490 aa)
ak8Adenylate kinase 8; Belongs to the adenylate kinase family. (461 aa)
ENSACLP00000013221Adenosine deaminase 2a. (470 aa)
NT5C3B-25'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (281 aa)
ak1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (211 aa)
LOC113030808Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (473 aa)
ENSACLP00000016813Phosphoribosylformylglycinamidine synthase. (1254 aa)
ENSACLP00000017004Adenylosuccinate lyase. (411 aa)
ENSACLP00000017042Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (460 aa)
ENSACLP00000017095Uncharacterized protein. (199 aa)
ENSACLP00000017130Adenylosuccinate lyase. (422 aa)
LOC113018890GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (348 aa)
LOC1130143825'-nucleotidase, cytosolic IAa. (387 aa)
ENSACLP00000019526AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (742 aa)
pde1aPhosphodiesterase. (811 aa)
LOC113015949AIRC domain-containing protein. (1025 aa)
ENSACLP00000022352Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
gmprGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
ak9Adenylate kinase 9. (1716 aa)
adaAdenosine deaminase. (425 aa)
ak6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (174 aa)
pde1bPhosphodiesterase. (518 aa)
ENSACLP00000027113Phosphodiesterase. (554 aa)
ENSACLP00000027173Uncharacterized protein. (167 aa)
ENSACLP000000273495'-nucleotidase, cytosolic IIb. (521 aa)
impdh2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (552 aa)
LOC1130258185'-nucleotidase, cytosolic II, like 1. (526 aa)
ENSACLP00000028199MYB binding protein (P160) 1a. (1006 aa)
LOC113023773Calcium activated nucleotidase 1b. (459 aa)
LOC113009342Adenosine deaminase 2b. (502 aa)
atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (591 aa)
NT5M5',3'-nucleotidase, mitochondrial. (229 aa)
ak2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (249 aa)
ak3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (223 aa)
LOC113026360AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (775 aa)
LOC113008706Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (611 aa)
LOC113009906Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (225 aa)
LOC113006858Phosphodiesterase. (801 aa)
LOC113034691Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (449 aa)
LOC113022492AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (947 aa)
hprt1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
LOC113006691Ectonucleotide pyrophosphatase/phosphodiesterase 1. (795 aa)
ENSACLP00000036302Leucine-rich repeats and guanylate kinase domain containing. (758 aa)
gartTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1017 aa)
LOC113026882Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (625 aa)
cant1Calcium activated nucleotidase 1a. (406 aa)
ENSACLP00000038676dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (145 aa)
LOC113026921Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (215 aa)
LOC113006394Adenylate kinase 7a. (697 aa)
ENSACLP00000041593Uncharacterized protein. (164 aa)
ENSACLP00000041596AIRC domain-containing protein. (450 aa)
ENSACLP00000041597AIRC domain-containing protein. (318 aa)
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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