(24 nodes) Cul4-RING E3 ubiquitin ligase complex, and Protein deneddylation network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cops8	COP9 signalosome subunit 8. (191 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (891 aa)
	dcaf10	WD repeat domain 32. (533 aa)
	gps1	G protein pathway suppressor 1. (507 aa)
	dcaf6	Ddb1 and cul4 associated factor 6. (966 aa)
	COPS6	COP9 signalosome subunit 6. (346 aa)
	dcaf4	WD repeat domain 21. (510 aa)
	DDA1	DET1 and DDB1 associated 1. (100 aa)
	dcaf8	DDB1 and CUL4 associated factor 8. (616 aa)
	ddb1	Damage-specific DNA binding protein 1. (1140 aa)
	wdtc1	WD and tetratricopeptide repeats 1. (675 aa)
	ddb2	Damage-specific DNA binding protein 2. (543 aa)
	ercc8	Excision repair cross-complementation group 8. (424 aa)
	dcaf11	DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat LEC14B family. (546 aa)
	cops2	COP9 signalosome subunit 2. (443 aa)
	cops3	COP9 signalosome subunit 3. (428 aa)
	dtl	Denticleless E3 ubiquitin protein ligase homolog (Drosophila). (661 aa)
	ENSACLP00000034749	WD_REPEATS_REGION domain-containing protein. (132 aa)
	ENSACLP00000035328	Cullin 4A; Belongs to the cullin family. (760 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1472 aa)
	cops7a	COP9 constitutive photomorphogenic homolog subunit 7A. (268 aa)
	cops4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis). (406 aa)
	cops5	COP9 signalosome subunit 5. (334 aa)
	dcaf5	Ddb1 and cul4 associated factor 5. (801 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COPS6	DCAF1	ENSACLP00000005690	ENSACLP00000037035	COP9 signalosome subunit 6.	DDB1 and CUL4 associated factor 1.	0.557
COPS6	DDA1	ENSACLP00000005690	ENSACLP00000012072	COP9 signalosome subunit 6.	DET1 and DDB1 associated 1.	0.681
COPS6	ENSACLP00000034749	ENSACLP00000005690	ENSACLP00000034749	COP9 signalosome subunit 6.	WD_REPEATS_REGION domain-containing protein.	0.729
COPS6	ENSACLP00000035328	ENSACLP00000005690	ENSACLP00000035328	COP9 signalosome subunit 6.	Cullin 4A; Belongs to the cullin family.	0.945
COPS6	cops2	ENSACLP00000005690	ENSACLP00000024976	COP9 signalosome subunit 6.	COP9 signalosome subunit 2.	0.999
COPS6	cops3	ENSACLP00000005690	ENSACLP00000031366	COP9 signalosome subunit 6.	COP9 signalosome subunit 3.	0.999
COPS6	cops4	ENSACLP00000005690	ENSACLP00000037578	COP9 signalosome subunit 6.	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis).	0.999
COPS6	cops5	ENSACLP00000005690	ENSACLP00000038361	COP9 signalosome subunit 6.	COP9 signalosome subunit 5.	0.998
COPS6	cops7a	ENSACLP00000005690	ENSACLP00000037325	COP9 signalosome subunit 6.	COP9 constitutive photomorphogenic homolog subunit 7A.	0.994
COPS6	cops8	ENSACLP00000005690	ENSACLP00000000852	COP9 signalosome subunit 6.	COP9 signalosome subunit 8.	0.998
COPS6	cul4b	ENSACLP00000005690	ENSACLP00000001998	COP9 signalosome subunit 6.	Cullin 4B; Belongs to the cullin family.	0.945
COPS6	dcaf10	ENSACLP00000005690	ENSACLP00000002170	COP9 signalosome subunit 6.	WD repeat domain 32.	0.563
COPS6	dcaf11	ENSACLP00000005690	ENSACLP00000024409	COP9 signalosome subunit 6.	DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat LEC14B family.	0.925
COPS6	dcaf4	ENSACLP00000005690	ENSACLP00000009841	COP9 signalosome subunit 6.	WD repeat domain 21.	0.848
COPS6	dcaf5	ENSACLP00000005690	ENSACLP00000040359	COP9 signalosome subunit 6.	Ddb1 and cul4 associated factor 5.	0.672
COPS6	dcaf6	ENSACLP00000005690	ENSACLP00000004185	COP9 signalosome subunit 6.	Ddb1 and cul4 associated factor 6.	0.550
COPS6	dcaf8	ENSACLP00000005690	ENSACLP00000014214	COP9 signalosome subunit 6.	DDB1 and CUL4 associated factor 8.	0.635
COPS6	ddb1	ENSACLP00000005690	ENSACLP00000018313	COP9 signalosome subunit 6.	Damage-specific DNA binding protein 1.	0.941
COPS6	ddb2	ENSACLP00000005690	ENSACLP00000020982	COP9 signalosome subunit 6.	Damage-specific DNA binding protein 2.	0.942
COPS6	dtl	ENSACLP00000005690	ENSACLP00000034658	COP9 signalosome subunit 6.	Denticleless E3 ubiquitin protein ligase homolog (Drosophila).	0.729