(13 nodes) Mixed, incl. SH2 adaptor protein C, SH2 domain, and Core histone H2A/H2B/H3/H4 network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113016116	SHC (Src homology 2 domain containing) transforming protein 2. (726 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1331 aa)
	ENSACLP00000006489	Son of sevenless homolog 1 (Drosophila). (1443 aa)
	SHC3	SHC adaptor protein 3. (661 aa)
	ENSACLP00000014200	Receptor protein-tyrosine kinase. (1407 aa)
	ENSACLP00000019486	Protein tyrosine phosphatase non-receptor type 11b. (547 aa)
	LOC113029559	Receptor protein-tyrosine kinase. (1175 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (600 aa)
	LOC113020258	Uncharacterized protein. (220 aa)
	gab2	GRB2-associated binding protein 2. (654 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
	gab1	GRB2-associated binding protein 1. (746 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000006489	ENSACLP00000014200	ENSACLP00000006489	ENSACLP00000014200	Son of sevenless homolog 1 (Drosophila).	Receptor protein-tyrosine kinase.	0.833
ENSACLP00000006489	ENSACLP00000019486	ENSACLP00000006489	ENSACLP00000019486	Son of sevenless homolog 1 (Drosophila).	Protein tyrosine phosphatase non-receptor type 11b.	0.934
ENSACLP00000006489	LOC113016116	ENSACLP00000006489	ENSACLP00000000682	Son of sevenless homolog 1 (Drosophila).	SHC (Src homology 2 domain containing) transforming protein 2.	0.884
ENSACLP00000006489	LOC113020258	ENSACLP00000006489	ENSACLP00000030912	Son of sevenless homolog 1 (Drosophila).	Uncharacterized protein.	0.920
ENSACLP00000006489	LOC113029559	ENSACLP00000006489	ENSACLP00000026696	Son of sevenless homolog 1 (Drosophila).	Receptor protein-tyrosine kinase.	0.941
ENSACLP00000006489	SHC3	ENSACLP00000006489	ENSACLP00000009889	Son of sevenless homolog 1 (Drosophila).	SHC adaptor protein 3.	0.901
ENSACLP00000006489	gab1	ENSACLP00000006489	ENSACLP00000037247	Son of sevenless homolog 1 (Drosophila).	GRB2-associated binding protein 1.	0.881
ENSACLP00000006489	gab2	ENSACLP00000006489	ENSACLP00000033920	Son of sevenless homolog 1 (Drosophila).	GRB2-associated binding protein 2.	0.878
ENSACLP00000006489	grb2	ENSACLP00000006489	ENSACLP00000027361	Son of sevenless homolog 1 (Drosophila).	Growth factor receptor-bound protein 2b.	0.991
ENSACLP00000006489	ptpn11	ENSACLP00000006489	ENSACLP00000036374	Son of sevenless homolog 1 (Drosophila).	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.934
ENSACLP00000006489	shc1	ENSACLP00000006489	ENSACLP00000027718	Son of sevenless homolog 1 (Drosophila).	SHC (Src homology 2 domain containing) transforming protein 1.	0.901
ENSACLP00000006489	sos2	ENSACLP00000006489	ENSACLP00000002674	Son of sevenless homolog 1 (Drosophila).	Son of sevenless homolog 2 (Drosophila).	0.818
ENSACLP00000014200	ENSACLP00000006489	ENSACLP00000014200	ENSACLP00000006489	Receptor protein-tyrosine kinase.	Son of sevenless homolog 1 (Drosophila).	0.833
ENSACLP00000014200	ENSACLP00000019486	ENSACLP00000014200	ENSACLP00000019486	Receptor protein-tyrosine kinase.	Protein tyrosine phosphatase non-receptor type 11b.	0.810
ENSACLP00000014200	LOC113016116	ENSACLP00000014200	ENSACLP00000000682	Receptor protein-tyrosine kinase.	SHC (Src homology 2 domain containing) transforming protein 2.	0.941
ENSACLP00000014200	LOC113020258	ENSACLP00000014200	ENSACLP00000030912	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.928
ENSACLP00000014200	SHC3	ENSACLP00000014200	ENSACLP00000009889	Receptor protein-tyrosine kinase.	SHC adaptor protein 3.	0.947
ENSACLP00000014200	gab1	ENSACLP00000014200	ENSACLP00000037247	Receptor protein-tyrosine kinase.	GRB2-associated binding protein 1.	0.743
ENSACLP00000014200	gab2	ENSACLP00000014200	ENSACLP00000033920	Receptor protein-tyrosine kinase.	GRB2-associated binding protein 2.	0.710
ENSACLP00000014200	grb2	ENSACLP00000014200	ENSACLP00000027361	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2b.	0.971