(46 nodes) Regulation of double-strand break repair via homologous recombination network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSACLP00000030513	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (469 aa)
	actr2	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
	shld2	Si:ch211-134m17.9. (753 aa)
	arid2	AT rich interactive domain 2 (ARID, RFX-like). (1702 aa)
	LOC113010023	Enhancer of polycomb homolog. (838 aa)
	ENSACLP00000002696	PWWP domain-containing protein. (110 aa)
	sirt6	Sirtuin 6. (351 aa)
	RTEL1	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1123 aa)
	timeless	Timeless circadian clock. (1249 aa)
	fbh1	F-box DNA helicase 1. (1077 aa)
	rmi2	RecQ mediated genome instability 2. (146 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2605 aa)
	ENSACLP00000008753	Uncharacterized protein. (436 aa)
	LOC113034173	Uncharacterized protein. (237 aa)
	ercc6	Excision repair cross-complementation group 6. (1439 aa)
	ENSACLP00000010589	Tumor protein p53 binding protein, 1. (1505 aa)
	recql5	RecQ helicase-like 5. (1018 aa)
	radx	RPA1 related single stranded DNA binding protein. (843 aa)
	ENSACLP00000015558	Helicase, POLQ like. (821 aa)
	LOC113029328	Enhancer of polycomb homolog. (845 aa)
	mrgbp	MRG/MORF4L binding protein. (220 aa)
	vps72	Vacuolar protein sorting 72 homolog a. (366 aa)
	LOC113018933	Zgc:101810; Belongs to the actin family. (394 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (852 aa)
	ENSACLP00000022849	Uncharacterized protein. (578 aa)
	ENSACLP00000022919	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (999 aa)
	ENSACLP00000022953	Pogo transposable element derived with ZNF domain b. (1877 aa)
	ENSACLP00000023083	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (2569 aa)
	terf2ip	Uncharacterized protein. (685 aa)
	parpbp	PARP1 binding protein. (587 aa)
	ENSACLP00000026809	Uncharacterized protein. (1222 aa)
	mms19	MMS19 homolog, cytosolic iron-sulfur assembly component. (1031 aa)
	wdr48	WD repeat domain 48b. (685 aa)
	spidr	Uncharacterized protein. (935 aa)
	ENSACLP00000027673	Uncharacterized protein. (76 aa)
	wrap53	WD repeat containing, antisense to TP53. (545 aa)
	ENSACLP00000028424	Uncharacterized protein. (79 aa)
	dmap1	DNA methyltransferase 1 associated protein 1. (481 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
	ENSACLP00000002677	LEDGF domain-containing protein. (309 aa)
	LOC113014662	Mab-21 domain-containing protein. (512 aa)
	ENSACLP00000033624	Bromo domain-containing protein. (257 aa)
	ENSACLP00000033646	Uncharacterized protein. (94 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (507 aa)
	yeats4	YEATS domain containing 4. (226 aa)
	ENSACLP00000002055	Structural maintenance of chromosomes flexible hinge domain containing 1. (1782 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000002055	SETD2	ENSACLP00000002055	ENSACLP00000008159	Structural maintenance of chromosomes flexible hinge domain containing 1.	SET domain containing 2, histone lysine methyltransferase.	0.407
ENSACLP00000002677	ENSACLP00000002696	ENSACLP00000002677	ENSACLP00000002696	LEDGF domain-containing protein.	PWWP domain-containing protein.	0.880
ENSACLP00000002677	kdm1a	ENSACLP00000002677	ENSACLP00000022320	LEDGF domain-containing protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.461
ENSACLP00000002696	ENSACLP00000002677	ENSACLP00000002696	ENSACLP00000002677	PWWP domain-containing protein.	LEDGF domain-containing protein.	0.880
ENSACLP00000002696	kdm1a	ENSACLP00000002696	ENSACLP00000022320	PWWP domain-containing protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.461
ENSACLP00000008753	ENSACLP00000015558	ENSACLP00000008753	ENSACLP00000015558	Uncharacterized protein.	Helicase, POLQ like.	0.571
ENSACLP00000008753	wdr48	ENSACLP00000008753	ENSACLP00000027363	Uncharacterized protein.	WD repeat domain 48b.	0.745
ENSACLP00000010589	ENSACLP00000022919	ENSACLP00000010589	ENSACLP00000022919	Tumor protein p53 binding protein, 1.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.584
ENSACLP00000010589	ENSACLP00000030513	ENSACLP00000010589	ENSACLP00000030513	Tumor protein p53 binding protein, 1.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.967
ENSACLP00000010589	LOC113034173	ENSACLP00000010589	ENSACLP00000009124	Tumor protein p53 binding protein, 1.	Uncharacterized protein.	0.475
ENSACLP00000010589	SETD2	ENSACLP00000010589	ENSACLP00000008159	Tumor protein p53 binding protein, 1.	SET domain containing 2, histone lysine methyltransferase.	0.416
ENSACLP00000010589	ercc6	ENSACLP00000010589	ENSACLP00000009687	Tumor protein p53 binding protein, 1.	Excision repair cross-complementation group 6.	0.458
ENSACLP00000010589	fbh1	ENSACLP00000010589	ENSACLP00000006307	Tumor protein p53 binding protein, 1.	F-box DNA helicase 1.	0.794
ENSACLP00000010589	kdm1a	ENSACLP00000010589	ENSACLP00000022320	Tumor protein p53 binding protein, 1.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.493
ENSACLP00000010589	pias4	ENSACLP00000010589	ENSACLP00000034184	Tumor protein p53 binding protein, 1.	Protein inhibitor of activated STAT, 4a.	0.809
ENSACLP00000010589	rad51	ENSACLP00000010589	ENSACLP00000030353	Tumor protein p53 binding protein, 1.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.818
ENSACLP00000010589	recql5	ENSACLP00000010589	ENSACLP00000012242	Tumor protein p53 binding protein, 1.	RecQ helicase-like 5.	0.791
ENSACLP00000010589	shld2	ENSACLP00000010589	ENSACLP00000004607	Tumor protein p53 binding protein, 1.	Si:ch211-134m17.9.	0.520
ENSACLP00000010589	sirt6	ENSACLP00000010589	ENSACLP00000004612	Tumor protein p53 binding protein, 1.	Sirtuin 6.	0.422
ENSACLP00000010589	timeless	ENSACLP00000010589	ENSACLP00000005627	Tumor protein p53 binding protein, 1.	Timeless circadian clock.	0.926