(60 nodes) Peptide hormone binding network (Astatotilapia calliptera)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ednrb	Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (419 aa)
	ENSACLP00000022825	Guanylate cyclase. (1086 aa)
	gpr1	G protein-coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	pth2r	Parathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family. (551 aa)
	ENSACLP00000010737	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (428 aa)
	LOC113007272	Receptor activity modifying protein 1. (150 aa)
	ENSACLP00000005086	Uncharacterized protein. (120 aa)
	ENSACLP00000003812	Si:ch211-215j19.12; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (177 aa)
	ENSACLP00000003549	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (588 aa)
	slc40a1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (567 aa)
	GUCY2C	Guanylate cyclase. (1078 aa)
	c2cd2l	C2cd2 like. (690 aa)
	LOC113034140	Growth hormone receptor a. (643 aa)
	ENSACLP00000021262	Growth hormone releasing hormone receptor a; Belongs to the G-protein coupled receptor 2 family. (437 aa)
	ENSACLP00000021133	G_PROTEIN_RECEP_F2_3 domain-containing protein. (79 aa)
	ENSACLP00000021099	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family. (313 aa)
	LOC113010475	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family. (472 aa)
	lepr	Leptin receptor. (1181 aa)
	LOC113014959	Galanin receptor 1a; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	LOC113029441	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (442 aa)
	LOC113033733	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	ENSACLP00000016961	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (355 aa)
	LOC113016075	Fibronectin type-III domain-containing protein. (543 aa)
	LOC113016634	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily. (506 aa)
	ebi3	Epstein-Barr virus induced 3. (242 aa)
	LOC113019353	Parathyroid hormone 1 receptor b; Belongs to the G-protein coupled receptor 2 family. (561 aa)
	ENSACLP00000010190	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (366 aa)
	LOC113014284	Guanylate cyclase. (1067 aa)
	LOC113008369	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (447 aa)
	ENSACLP00000005347	Receptor (G protein-coupled) activity modifying protein 2. (239 aa)
	ENSACLP00000014140	Uncharacterized protein. (122 aa)
	CCKAR	Cholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (452 aa)
	LOC113026027	Guanylate cyclase. (1056 aa)
	LOC113016759	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (457 aa)
	LOC113016497	Si:dkey-1h24.2; Belongs to the G-protein coupled receptor 1 family. (445 aa)
	vipr1	Vasoactive intestinal peptide receptor 1b; Belongs to the G-protein coupled receptor 2 family. (442 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	ENSACLP00000037564	Guanylate cyclase. (1060 aa)
	ghrhr	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (413 aa)
	LOC113026813	Galanin receptor 1b; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	GLP2R	Glucagon like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family. (531 aa)
	LOC113033752	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (425 aa)
	LOC113009011	Growth hormone releasing hormone receptor b; Belongs to the G-protein coupled receptor 2 family. (469 aa)
	LOC113009010	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family. (446 aa)
	gcgr	Glucagon receptor a; Belongs to the G-protein coupled receptor 2 family. (525 aa)
	galr1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	LOC113028026	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (436 aa)
	ENSACLP00000032632	Glucagon receptor b; Belongs to the G-protein coupled receptor 2 family. (509 aa)
	LOC113027827	Uncharacterized protein. (201 aa)
	LOC113019459	Guanylate cyclase. (868 aa)
	LOC113027606	Guanylate cyclase. (1076 aa)
	LOC113010520	Vasoactive intestinal peptide receptor 1a; Belongs to the G-protein coupled receptor 2 family. (445 aa)
	ENSACLP00000028012	Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (424 aa)
	LOC113034567	Insulin-degrading enzyme; Belongs to the peptidase M16 family. (978 aa)
	LOC113034568	Insulin-degrading enzyme; Belongs to the peptidase M16 family. (978 aa)
	pth1r	Parathyroid hormone 1 receptor a; Belongs to the G-protein coupled receptor 2 family. (534 aa)
	vipr2	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (436 aa)
	ghr	Growth hormone receptor b. (591 aa)
	ENSACLP00000024964	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (456 aa)
	npr3	PDZ domain-containing protein. (830 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCKAR	LOC113008369	ENSACLP00000013076	ENSACLP00000006165	Cholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.851
CCKAR	LOC113016497	ENSACLP00000013076	ENSACLP00000040173	Cholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family.	Si:dkey-1h24.2; Belongs to the G-protein coupled receptor 1 family.	0.851
ENSACLP00000003549	slc40a1	ENSACLP00000003549	ENSACLP00000003057	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.851
ENSACLP00000003812	GUCY2C	ENSACLP00000003812	ENSACLP00000022386	Si:ch211-215j19.12; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase.	0.549
ENSACLP00000003812	LOC113027606	ENSACLP00000003812	ENSACLP00000028568	Si:ch211-215j19.12; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase.	0.553
ENSACLP00000005086	ENSACLP00000005347	ENSACLP00000005086	ENSACLP00000005347	Uncharacterized protein.	Receptor (G protein-coupled) activity modifying protein 2.	0.839
ENSACLP00000005086	ENSACLP00000010190	ENSACLP00000005086	ENSACLP00000010190	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.633
ENSACLP00000005086	ENSACLP00000016961	ENSACLP00000005086	ENSACLP00000016961	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.633
ENSACLP00000005086	ENSACLP00000021099	ENSACLP00000005086	ENSACLP00000021099	Uncharacterized protein.	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family.	0.633
ENSACLP00000005086	ENSACLP00000021133	ENSACLP00000005086	ENSACLP00000021133	Uncharacterized protein.	G_PROTEIN_RECEP_F2_3 domain-containing protein.	0.633
ENSACLP00000005086	ENSACLP00000021262	ENSACLP00000005086	ENSACLP00000021262	Uncharacterized protein.	Growth hormone releasing hormone receptor a; Belongs to the G-protein coupled receptor 2 family.	0.633
ENSACLP00000005086	ENSACLP00000024964	ENSACLP00000005086	ENSACLP00000024964	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.633
ENSACLP00000005086	ENSACLP00000028012	ENSACLP00000005086	ENSACLP00000028012	Uncharacterized protein.	Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family.	0.633
ENSACLP00000005086	ENSACLP00000032632	ENSACLP00000005086	ENSACLP00000032632	Uncharacterized protein.	Glucagon receptor b; Belongs to the G-protein coupled receptor 2 family.	0.633
ENSACLP00000005086	GLP2R	ENSACLP00000005086	ENSACLP00000035347	Uncharacterized protein.	Glucagon like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family.	0.633
ENSACLP00000005086	LOC113009010	ENSACLP00000005086	ENSACLP00000033773	Uncharacterized protein.	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	0.633
ENSACLP00000005086	LOC113009011	ENSACLP00000005086	ENSACLP00000033848	Uncharacterized protein.	Growth hormone releasing hormone receptor b; Belongs to the G-protein coupled receptor 2 family.	0.633
ENSACLP00000005086	LOC113010475	ENSACLP00000005086	ENSACLP00000021068	Uncharacterized protein.	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	0.633
ENSACLP00000005086	LOC113010520	ENSACLP00000005086	ENSACLP00000028522	Uncharacterized protein.	Vasoactive intestinal peptide receptor 1a; Belongs to the G-protein coupled receptor 2 family.	0.633
ENSACLP00000005086	LOC113016759	ENSACLP00000005086	ENSACLP00000040772	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.633