(8 nodes) Mitotic DNA replication checkpoint signaling network (Astatotilapia calliptera)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	ENSACLP00000007188	DNA topoisomerase II binding protein 1. (1484 aa)
	ticrr	Treslin_N domain-containing protein. (1869 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (602 aa)
	rad17	RAD17 checkpoint clamp loader component. (630 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (285 aa)
	ZNF830	Zinc finger protein 830. (352 aa)
	CLSPN	Claspin. (1037 aa)
	orc1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (899 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLSPN	ENSACLP00000007188	ENSACLP00000007596	ENSACLP00000007188	Claspin.	DNA topoisomerase II binding protein 1.	0.849
CLSPN	cdc6	ENSACLP00000007596	ENSACLP00000024317	Claspin.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.901
CLSPN	hus1	ENSACLP00000007596	ENSACLP00000027123	Claspin.	Checkpoint protein; Belongs to the HUS1 family.	0.577
CLSPN	orc1	ENSACLP00000007596	ENSACLP00000031746	Claspin.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.945
CLSPN	rad17	ENSACLP00000007596	ENSACLP00000025470	Claspin.	RAD17 checkpoint clamp loader component.	0.664
CLSPN	ticrr	ENSACLP00000007596	ENSACLP00000034337	Claspin.	Treslin_N domain-containing protein.	0.620
ENSACLP00000007188	CLSPN	ENSACLP00000007188	ENSACLP00000007596	DNA topoisomerase II binding protein 1.	Claspin.	0.849
ENSACLP00000007188	cdc6	ENSACLP00000007188	ENSACLP00000024317	DNA topoisomerase II binding protein 1.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.618
ENSACLP00000007188	hus1	ENSACLP00000007188	ENSACLP00000027123	DNA topoisomerase II binding protein 1.	Checkpoint protein; Belongs to the HUS1 family.	0.911
ENSACLP00000007188	rad17	ENSACLP00000007188	ENSACLP00000025470	DNA topoisomerase II binding protein 1.	RAD17 checkpoint clamp loader component.	0.935
ENSACLP00000007188	ticrr	ENSACLP00000007188	ENSACLP00000034337	DNA topoisomerase II binding protein 1.	Treslin_N domain-containing protein.	0.930
ZNF830	ticrr	ENSACLP00000029077	ENSACLP00000034337	Zinc finger protein 830.	Treslin_N domain-containing protein.	0.637
cdc6	CLSPN	ENSACLP00000024317	ENSACLP00000007596	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Claspin.	0.901
cdc6	ENSACLP00000007188	ENSACLP00000024317	ENSACLP00000007188	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	DNA topoisomerase II binding protein 1.	0.618
cdc6	orc1	ENSACLP00000024317	ENSACLP00000031746	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.999
cdc6	rad17	ENSACLP00000024317	ENSACLP00000025470	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	RAD17 checkpoint clamp loader component.	0.718
cdc6	ticrr	ENSACLP00000024317	ENSACLP00000034337	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Treslin_N domain-containing protein.	0.606
hus1	CLSPN	ENSACLP00000027123	ENSACLP00000007596	Checkpoint protein; Belongs to the HUS1 family.	Claspin.	0.577
hus1	ENSACLP00000007188	ENSACLP00000027123	ENSACLP00000007188	Checkpoint protein; Belongs to the HUS1 family.	DNA topoisomerase II binding protein 1.	0.911
hus1	rad17	ENSACLP00000027123	ENSACLP00000025470	Checkpoint protein; Belongs to the HUS1 family.	RAD17 checkpoint clamp loader component.	0.996