(27 nodes) CD4-positive, alpha-beta T cell activation network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSACLP00000018362	Serine/threonine-protein kinase TOR. (2384 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	ENSACLP00000001494	SAM and SH3 domain containing 3. (389 aa)
	LOC113029203	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (347 aa)
	cd83	Ig-like domain-containing protein. (225 aa)
	LOC113010677	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (482 aa)
	LOC113030442	Fibronectin type-III domain-containing protein. (344 aa)
	nkx2-3	NK2 homeobox 3. (344 aa)
	LOC113008336	IGv domain-containing protein. (234 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (576 aa)
	card11	Caspase recruitment domain family, member 11. (1162 aa)
	LOC113024686	Homeobox domain-containing protein. (358 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (123 aa)
	LOC113033540	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (449 aa)
	LOC113013680	E3 ubiquitin-protein ligase. (888 aa)
	LOC113031710	Uncharacterized protein. (726 aa)
	LOC113022832	Cadherin 27. (990 aa)
	LOC113021975	E3 ubiquitin-protein ligase. (864 aa)
	ENSACLP00000032642	Lymphoid enhancer-binding factor 1. (341 aa)
	LOC113025905	Ring finger and CCCH-type domains 2. (1153 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (379 aa)
	tbx21	T-box transcription factor 21. (621 aa)
	armc5	Armadillo repeat containing 5. (1236 aa)
	stoml2	Stomatin (EPB72)-like 2. (356 aa)
	LOC113007951	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1125 aa)
	LOC113025522	Prostaglandin E receptor 4 (subtype EP4) b. (449 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000001494	LOC113030442	ENSACLP00000001494	ENSACLP00000013910	SAM and SH3 domain containing 3.	Fibronectin type-III domain-containing protein.	0.454
ENSACLP00000032642	LOC113013680	ENSACLP00000032642	ENSACLP00000021012	Lymphoid enhancer-binding factor 1.	E3 ubiquitin-protein ligase.	0.454
ENSACLP00000032642	LOC113021975	ENSACLP00000032642	ENSACLP00000030682	Lymphoid enhancer-binding factor 1.	E3 ubiquitin-protein ligase.	0.454
ENSACLP00000032642	tbx21	ENSACLP00000032642	ENSACLP00000035633	Lymphoid enhancer-binding factor 1.	T-box transcription factor 21.	0.440
LOC113013680	ENSACLP00000032642	ENSACLP00000021012	ENSACLP00000032642	E3 ubiquitin-protein ligase.	Lymphoid enhancer-binding factor 1.	0.454
LOC113013680	LOC113021975	ENSACLP00000021012	ENSACLP00000030682	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.816
LOC113013680	ripk2	ENSACLP00000021012	ENSACLP00000015326	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.686
LOC113021975	ENSACLP00000032642	ENSACLP00000030682	ENSACLP00000032642	E3 ubiquitin-protein ligase.	Lymphoid enhancer-binding factor 1.	0.454
LOC113021975	LOC113013680	ENSACLP00000030682	ENSACLP00000021012	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.816
LOC113021975	ripk2	ENSACLP00000030682	ENSACLP00000015326	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.686
LOC113025905	rc3h1	ENSACLP00000034166	ENSACLP00000040084	Ring finger and CCCH-type domains 2.	Ring finger and CCCH-type domains 1b.	0.817
LOC113029203	LOC113030442	ENSACLP00000001945	ENSACLP00000013910	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	Fibronectin type-III domain-containing protein.	0.853
LOC113029203	LOC113031710	ENSACLP00000001945	ENSACLP00000026585	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	Uncharacterized protein.	0.887
LOC113030442	ENSACLP00000001494	ENSACLP00000013910	ENSACLP00000001494	Fibronectin type-III domain-containing protein.	SAM and SH3 domain containing 3.	0.454
LOC113030442	LOC113029203	ENSACLP00000013910	ENSACLP00000001945	Fibronectin type-III domain-containing protein.	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	0.853
LOC113030442	LOC113031710	ENSACLP00000013910	ENSACLP00000026585	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.854
LOC113031710	LOC113029203	ENSACLP00000026585	ENSACLP00000001945	Uncharacterized protein.	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	0.887
LOC113031710	LOC113030442	ENSACLP00000026585	ENSACLP00000013910	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.854
batf	tbx21	ENSACLP00000018645	ENSACLP00000035633	Basic leucine zipper transcription factor, ATF-like.	T-box transcription factor 21.	0.426
card11	ripk2	ENSACLP00000016311	ENSACLP00000015326	Caspase recruitment domain family, member 11.	Receptor-interacting serine-threonine kinase 2.	0.714