(88 nodes) Negative regulation of binding network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mitd1	MIT, microtubule interacting and transport, domain containing 1. (246 aa)
	sympk	Symplekin. (1221 aa)
	LOC113020037	Info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a. (576 aa)
	pln	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (53 aa)
	bag2	BCL2 associated athanogene 2. (208 aa)
	LOC113032369	Uncharacterized protein. (190 aa)
	LOC113024484	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	ENSACLP00000005889	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (540 aa)
	CTSZ	Cathepsin Z; Belongs to the peptidase C1 family. (303 aa)
	ENSACLP00000006235	Cathepsin Z; Belongs to the peptidase C1 family. (308 aa)
	bax	Uncharacterized protein. (205 aa)
	ENSACLP00000006475	Uncharacterized protein. (165 aa)
	LOC113026110	JunE proto-oncogene, AP-1 transcription factor subunit. (347 aa)
	pex19	Peroxisomal biogenesis factor 19. (291 aa)
	ENSACLP00000007775	Nuclear factor of activated T cells 4. (849 aa)
	il10	Interleukin 10. (182 aa)
	ENSACLP00000008485	SERPINE1 mRNA binding protein 1a. (375 aa)
	ENSACLP00000008556	Ankyrin repeat domain 33Aa. (270 aa)
	LOC113022671	MyoD family inhibitor. (300 aa)
	LOC113034543	Muscle segment homeobox 3. (255 aa)
	dpm1	Activity-dependent neuroprotector homeobox b. (1276 aa)
	dhrs7b	Dehydrogenase/reductase (SDR family) member 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (311 aa)
	efhb	EF-hand domain family, member B. (578 aa)
	LOC113010961	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (298 aa)
	ttbk2	Tau tubulin kinase 2a. (1239 aa)
	pdgfb	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (554 aa)
	ZNF462	Zinc finger protein 462. (2534 aa)
	msx1	Muscle segment homeobox 1a. (283 aa)
	LOC113021108	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (515 aa)
	ENSACLP00000017262	Uncharacterized protein. (312 aa)
	ENSACLP00000017301	Uncharacterized protein. (326 aa)
	LOC113010630	Uncharacterized protein. (345 aa)
	ENSACLP00000017439	Uncharacterized protein. (364 aa)
	ENSACLP00000017495	Uncharacterized protein. (376 aa)
	ENSACLP00000017541	Uncharacterized protein. (357 aa)
	ENSACLP00000018137	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (261 aa)
	styx	Serine/threonine/tyrosine interacting protein. (259 aa)
	ttbk1	Tau tubulin kinase 1a. (1286 aa)
	LOC113012897	Zgc:113363. (254 aa)
	LOC113033689	Hyaluronan binding protein 4. (357 aa)
	pcsk9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (669 aa)
	ENSACLP00000020797	Uncharacterized protein. (83 aa)
	e2f1	E2F transcription factor 1. (454 aa)
	LOC113023685	Low density lipoprotein receptor-related protein associated protein 1. (347 aa)
	ENSACLP00000021370	Low density lipoprotein receptor-related protein associated protein 1. (337 aa)
	ENSACLP00000021934	FERM domain-containing protein. (287 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (852 aa)
	LOC113035053	Dickkopf WNT signaling pathway inhibitor 1a. (253 aa)
	LOC113014242	Dystrobrevin binding protein 1b. (272 aa)
	znf593	Zinc finger protein 593. (129 aa)
	ercc4	Excision repair cross-complementation group 4. (899 aa)
	ENSACLP00000026925	Uncharacterized protein. (55 aa)
	btaf1	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated. (1856 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (202 aa)
	ddit3	DNA-damage-inducible transcript 3. (308 aa)
	LOC113027962	WAPL cohesin release factor b. (1213 aa)
	sorl1	Sortilin-related receptor, L(DLR class) A repeats containing. (2262 aa)
	ENSACLP00000029386	Uncharacterized protein. (2395 aa)
	ENSACLP00000029906	Inhibitor of DNA binding 1, HLH protein. (130 aa)
	LOC113029778	Ankyrin repeat domain 33ba. (534 aa)
	LOC113022894	GATA binding protein 1a. (424 aa)
	gnl3l	Guanine nucleotide binding protein-like 3 (nucleolar)-like. (566 aa)
	ENSACLP00000031455	Leucine-rich repeat kinase 2. (2416 aa)
	wapl	WAPL cohesin release factor a. (1171 aa)
	ENSACLP00000032614	Ankyrin repeat domain 33Bb. (490 aa)
	ENSACLP00000032642	Lymphoid enhancer-binding factor 1. (341 aa)
	ENSACLP00000032760	Zgc:100846. (455 aa)
	psme3ip1	Family with sequence similarity 192 member A. (271 aa)
	ENSACLP00000033971	Tau tubulin kinase 2b. (420 aa)
	tdg	Thymine DNA glycosylase, tandem duplicate 1. (449 aa)
	LOC113026388	Thymine DNA glycosylase, tandem duplicate 2. (433 aa)
	ENSACLP00000034236	Remodeling and spacing factor 1b, tandem duplicate 1. (1246 aa)
	ENSACLP00000034312	Uncharacterized protein. (610 aa)
	LOC113027832	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b. (576 aa)
	nek2	NIMA-related kinase 2. (446 aa)
	NEK2	NIMA-related kinase 2. (425 aa)
	LOC113021701	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (165 aa)
	ENSACLP00000036146	Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family. (270 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (191 aa)
	TFAP4	Transcription factor AP-4. (330 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (825 aa)
	LOC113022550	Ankyrin repeat domain 33Ab. (480 aa)
	pex14	Peroxisomal biogenesis factor 14. (384 aa)
	GCA	Grancalcin. (311 aa)
	ENSACLP00000038448	Catenin, beta interacting protein 1. (79 aa)
	gtpbp4	GTP binding protein 4. (486 aa)
	dab2	DAB adaptor protein 2. (778 aa)
	LOC113020744	Transcription factor AP-4 (activating enhancer binding protein 4). (333 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000007775	LOC113022894	ENSACLP00000007775	ENSACLP00000031119	Nuclear factor of activated T cells 4.	GATA binding protein 1a.	0.825
ENSACLP00000018137	LOC113022894	ENSACLP00000018137	ENSACLP00000031119	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	GATA binding protein 1a.	0.465
ENSACLP00000018137	ddit3	ENSACLP00000018137	ENSACLP00000027832	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	DNA-damage-inducible transcript 3.	0.461
ENSACLP00000021370	sorl1	ENSACLP00000021370	ENSACLP00000029127	Low density lipoprotein receptor-related protein associated protein 1.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.867
ENSACLP00000032642	LOC113035053	ENSACLP00000032642	ENSACLP00000022426	Lymphoid enhancer-binding factor 1.	Dickkopf WNT signaling pathway inhibitor 1a.	0.506
ENSACLP00000032642	e2f1	ENSACLP00000032642	ENSACLP00000021156	Lymphoid enhancer-binding factor 1.	E2F transcription factor 1.	0.420
ENSACLP00000032642	msx1	ENSACLP00000032642	ENSACLP00000015584	Lymphoid enhancer-binding factor 1.	Muscle segment homeobox 1a.	0.518
ENSACLP00000034236	gnl3l	ENSACLP00000034236	ENSACLP00000031321	Remodeling and spacing factor 1b, tandem duplicate 1.	Guanine nucleotide binding protein-like 3 (nucleolar)-like.	0.422
ENSACLP00000034312	LOC113014242	ENSACLP00000034312	ENSACLP00000022538	Uncharacterized protein.	Dystrobrevin binding protein 1b.	0.538
ENSACLP00000036146	ercc4	ENSACLP00000036146	ENSACLP00000025304	Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family.	Excision repair cross-complementation group 4.	0.513
ENSACLP00000036146	il10	ENSACLP00000036146	ENSACLP00000008088	Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family.	Interleukin 10.	0.458
GCA	gnl3l	ENSACLP00000037877	ENSACLP00000031321	Grancalcin.	Guanine nucleotide binding protein-like 3 (nucleolar)-like.	0.475
HAND1	LOC113022894	ENSACLP00000036367	ENSACLP00000031119	Heart and neural crest derivatives expressed 1.	GATA binding protein 1a.	0.483
LOC113014242	ENSACLP00000034312	ENSACLP00000022538	ENSACLP00000034312	Dystrobrevin binding protein 1b.	Uncharacterized protein.	0.538
LOC113021108	sorl1	ENSACLP00000017151	ENSACLP00000029127	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.540
LOC113022894	ENSACLP00000007775	ENSACLP00000031119	ENSACLP00000007775	GATA binding protein 1a.	Nuclear factor of activated T cells 4.	0.825
LOC113022894	ENSACLP00000018137	ENSACLP00000031119	ENSACLP00000018137	GATA binding protein 1a.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.465
LOC113022894	HAND1	ENSACLP00000031119	ENSACLP00000036367	GATA binding protein 1a.	Heart and neural crest derivatives expressed 1.	0.483
LOC113022894	LOC113026110	ENSACLP00000031119	ENSACLP00000007182	GATA binding protein 1a.	JunE proto-oncogene, AP-1 transcription factor subunit.	0.465
LOC113023685	sorl1	ENSACLP00000021272	ENSACLP00000029127	Low density lipoprotein receptor-related protein associated protein 1.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.867