(13 nodes) Regulation of feeding behavior network (Astatotilapia calliptera)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113025266	Agouti domain-containing protein. (142 aa)
	LOC113029192	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	lepr	Leptin receptor. (1181 aa)
	ENSACLP00000003429	RWD domain-containing protein. (141 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1503 aa)
	LOC113022716	Vitamin D receptor b. (425 aa)
	ENSACLP00000016728	G protein-coupled receptor 171. (343 aa)
	ttc21b	Tetratricopeptide repeat domain 21B. (1318 aa)
	cfap20	Cilia and flagella associated protein 20. (194 aa)
	ENSACLP00000018508	Melanocortin 4 receptor. (315 aa)
	nmu	NMU domain-containing protein. (229 aa)
	spx	Spexin hormone. (120 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (113 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK4	ENSACLP00000003429	ENSACLP00000003454	ENSACLP00000003429	Eukaryotic translation initiation factor 2 alpha kinase 4.	RWD domain-containing protein.	0.865
ENSACLP00000003429	EIF2AK4	ENSACLP00000003429	ENSACLP00000003454	RWD domain-containing protein.	Eukaryotic translation initiation factor 2 alpha kinase 4.	0.865
ENSACLP00000018508	LOC113025266	ENSACLP00000018508	ENSACLP00000034926	Melanocortin 4 receptor.	Agouti domain-containing protein.	0.610
ENSACLP00000018508	lepr	ENSACLP00000018508	ENSACLP00000002988	Melanocortin 4 receptor.	Leptin receptor.	0.535
ENSACLP00000018508	nmu	ENSACLP00000018508	ENSACLP00000023017	Melanocortin 4 receptor.	NMU domain-containing protein.	0.451
ENSACLP00000018508	spx	ENSACLP00000018508	ENSACLP00000031703	Melanocortin 4 receptor.	Spexin hormone.	0.430
LOC113025266	ENSACLP00000018508	ENSACLP00000034926	ENSACLP00000018508	Agouti domain-containing protein.	Melanocortin 4 receptor.	0.610
LOC113025266	LOC113029192	ENSACLP00000034926	ENSACLP00000000633	Agouti domain-containing protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.411
LOC113025266	ins	ENSACLP00000034926	ENSACLP00000038798	Agouti domain-containing protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.411
LOC113025266	lepr	ENSACLP00000034926	ENSACLP00000002988	Agouti domain-containing protein.	Leptin receptor.	0.536
LOC113025266	spx	ENSACLP00000034926	ENSACLP00000031703	Agouti domain-containing protein.	Spexin hormone.	0.433
LOC113029192	LOC113025266	ENSACLP00000000633	ENSACLP00000034926	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Agouti domain-containing protein.	0.411
LOC113029192	spx	ENSACLP00000000633	ENSACLP00000031703	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Spexin hormone.	0.494
ins	LOC113025266	ENSACLP00000038798	ENSACLP00000034926	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Agouti domain-containing protein.	0.411
ins	spx	ENSACLP00000038798	ENSACLP00000031703	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Spexin hormone.	0.494
lepr	ENSACLP00000018508	ENSACLP00000002988	ENSACLP00000018508	Leptin receptor.	Melanocortin 4 receptor.	0.535
lepr	LOC113025266	ENSACLP00000002988	ENSACLP00000034926	Leptin receptor.	Agouti domain-containing protein.	0.536
nmu	ENSACLP00000018508	ENSACLP00000023017	ENSACLP00000018508	NMU domain-containing protein.	Melanocortin 4 receptor.	0.451
spx	ENSACLP00000018508	ENSACLP00000031703	ENSACLP00000018508	Spexin hormone.	Melanocortin 4 receptor.	0.430
spx	LOC113025266	ENSACLP00000031703	ENSACLP00000034926	Spexin hormone.	Agouti domain-containing protein.	0.433