(21 nodes) Cellular senescence network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSACLP00000003331	SMC_N domain-containing protein. (1078 aa)
	smc6	Si:dkey-119f1.1. (1088 aa)
	SRF	Serum response factor. (597 aa)
	CDKN2A	Cyclin dependent kinase inhibitor 2A. (131 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (715 aa)
	mnt	MAX network transcriptional repressor a. (600 aa)
	nsmce2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
	id2	Inhibitor of DNA binding 2a. (136 aa)
	spns1	Spinster homolog 1 (Drosophila). (506 aa)
	ENSACLP00000000444	Uncharacterized protein. (1863 aa)
	ecrg4	ECRG4 augurin precursor b. (143 aa)
	ENSACLP00000004637	Structural maintenance of chromosomes 6. (1100 aa)
	LOC113023510	MADS-box domain-containing protein. (517 aa)
	LOC113022663	Proline/arginine-rich end leucine-rich repeat protein. (379 aa)
	wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	LOC113030413	MAX network transcriptional repressor b. (602 aa)
	ENSACLP00000011398	T-box transcription factor 3b. (380 aa)
	becn1	Beclin 1, autophagy related. (447 aa)
	tbx3	T-box transcription factor 3a. (715 aa)
	mapkapk5	MAPK activated protein kinase 5. (471 aa)
	ENSACLP00000020797	Uncharacterized protein. (83 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDKN2A	ENSACLP00000000444	ENSACLP00000031360	ENSACLP00000000444	Cyclin dependent kinase inhibitor 2A.	Uncharacterized protein.	0.561
CDKN2A	becn1	ENSACLP00000031360	ENSACLP00000013630	Cyclin dependent kinase inhibitor 2A.	Beclin 1, autophagy related.	0.415
CDKN2A	sirt1	ENSACLP00000031360	ENSACLP00000030828	Cyclin dependent kinase inhibitor 2A.	Deacetylase sirtuin-type domain-containing protein.	0.430
ENSACLP00000000444	CDKN2A	ENSACLP00000000444	ENSACLP00000031360	Uncharacterized protein.	Cyclin dependent kinase inhibitor 2A.	0.561
ENSACLP00000000444	ENSACLP00000003331	ENSACLP00000000444	ENSACLP00000003331	Uncharacterized protein.	SMC_N domain-containing protein.	0.524
ENSACLP00000000444	ENSACLP00000004637	ENSACLP00000000444	ENSACLP00000004637	Uncharacterized protein.	Structural maintenance of chromosomes 6.	0.467
ENSACLP00000000444	smc6	ENSACLP00000000444	ENSACLP00000023970	Uncharacterized protein.	Si:dkey-119f1.1.	0.467
ENSACLP00000003331	ENSACLP00000000444	ENSACLP00000003331	ENSACLP00000000444	SMC_N domain-containing protein.	Uncharacterized protein.	0.524
ENSACLP00000003331	ENSACLP00000004637	ENSACLP00000003331	ENSACLP00000004637	SMC_N domain-containing protein.	Structural maintenance of chromosomes 6.	0.987
ENSACLP00000003331	nsmce2	ENSACLP00000003331	ENSACLP00000028367	SMC_N domain-containing protein.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.999
ENSACLP00000003331	sirt1	ENSACLP00000003331	ENSACLP00000030828	SMC_N domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.487
ENSACLP00000003331	smc6	ENSACLP00000003331	ENSACLP00000023970	SMC_N domain-containing protein.	Si:dkey-119f1.1.	0.987
ENSACLP00000004637	ENSACLP00000000444	ENSACLP00000004637	ENSACLP00000000444	Structural maintenance of chromosomes 6.	Uncharacterized protein.	0.467
ENSACLP00000004637	ENSACLP00000003331	ENSACLP00000004637	ENSACLP00000003331	Structural maintenance of chromosomes 6.	SMC_N domain-containing protein.	0.987
ENSACLP00000004637	nsmce2	ENSACLP00000004637	ENSACLP00000028367	Structural maintenance of chromosomes 6.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.983
ENSACLP00000011398	LOC113030413	ENSACLP00000011398	ENSACLP00000010635	T-box transcription factor 3b.	MAX network transcriptional repressor b.	0.444
ENSACLP00000011398	mnt	ENSACLP00000011398	ENSACLP00000030361	T-box transcription factor 3b.	MAX network transcriptional repressor a.	0.444
LOC113023510	SRF	ENSACLP00000006169	ENSACLP00000033145	MADS-box domain-containing protein.	Serum response factor.	0.852
LOC113030413	ENSACLP00000011398	ENSACLP00000010635	ENSACLP00000011398	MAX network transcriptional repressor b.	T-box transcription factor 3b.	0.444
LOC113030413	sirt1	ENSACLP00000010635	ENSACLP00000030828	MAX network transcriptional repressor b.	Deacetylase sirtuin-type domain-containing protein.	0.562