(58 nodes) Regulation of DNA biosynthetic process network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nox4	FAD-binding FR-type domain-containing protein. (559 aa)
	ing4	Inhibitor of growth protein. (249 aa)
	LOC113026054	Uncharacterized protein. (296 aa)
	chtf18	AAA domain-containing protein. (922 aa)
	ENSACLP00000001223	Uncharacterized protein. (496 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	map3k4	Mitogen-activated protein kinase kinase kinase 4. (1581 aa)
	exosc10	Exosome component 10. (890 aa)
	ENSACLP00000004087	Uncharacterized protein. (139 aa)
	gins3	GINS complex subunit 3. (211 aa)
	ENSACLP00000004131	TAN domain-containing protein. (177 aa)
	ENSACLP00000004294	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (524 aa)
	polg2	Polymerase (DNA directed), gamma 2, accessory subunit. (455 aa)
	ten1	TEN1 subunit of CST complex. (130 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (439 aa)
	ENSACLP00000008384	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2524 aa)
	cct3	T-complex protein 1 subunit gamma. (541 aa)
	nvl	Nuclear VCP like. (864 aa)
	gins2	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (180 aa)
	nat10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1035 aa)
	pdgfb	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (554 aa)
	parp4	Poly [ADP-ribose] polymerase. (1906 aa)
	gins4	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa)
	LOC113007501	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1199 aa)
	rfc2	Replication factor C (activator 1) 2. (356 aa)
	cct2	Chaperonin containing TCP1, subunit 2 (beta). (551 aa)
	ENSACLP00000016373	TERF1 (TRF1)-interacting nuclear factor 2. (522 aa)
	pnkp	Polynucleotide kinase 3'-phosphatase. (602 aa)
	ccdc174	Coiled-coil domain containing 174. (544 aa)
	rgcc	Regulator of cell cycle. (129 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1067 aa)
	LOC113021108	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (515 aa)
	pinx1	PIN2 (TERF1) interacting telomerase inhibitor 1. (377 aa)
	LOC113024563	HTH myb-type domain-containing protein. (706 aa)
	ENSACLP00000018225	TRF domain-containing protein. (535 aa)
	gfer	Sulfhydryl oxidase. (197 aa)
	mapkapk5	MAPK activated protein kinase 5. (471 aa)
	ing5	Inhibitor of growth protein. (240 aa)
	ENSACLP00000021335	Protection of telomeres 1 homolog. (696 aa)
	jade2	Jade family PHD finger 2. (930 aa)
	fbxo4	F-box protein 4. (396 aa)
	ENSACLP00000022217	Multiple endocrine neoplasia I. (629 aa)
	ENSACLP00000023026	Dyskeratosis congenita 1, dyskerin. (491 aa)
	xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5. (739 aa)
	ENSACLP00000025109	Uncharacterized protein. (413 aa)
	chtf8	CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (136 aa)
	wrap53	WD repeat containing, antisense to TP53. (545 aa)
	LOC113035495	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa)
	dcp2	Decapping mRNA 2. (391 aa)
	ENSACLP00000030513	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (469 aa)
	gnl3l	Guanine nucleotide binding protein-like 3 (nucleolar)-like. (566 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	grem1	Gremlin 1a, DAN family BMP antagonist. (179 aa)
	cct5	Chaperonin containing TCP1, subunit 5 (epsilon). (541 aa)
	nek2	NIMA-related kinase 2. (446 aa)
	NEK2	NIMA-related kinase 2. (425 aa)
	parp3	Poly [ADP-ribose] polymerase. (532 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000001223	ENSACLP00000016373	ENSACLP00000001223	ENSACLP00000016373	Uncharacterized protein.	TERF1 (TRF1)-interacting nuclear factor 2.	0.994
ENSACLP00000001223	ENSACLP00000018225	ENSACLP00000001223	ENSACLP00000018225	Uncharacterized protein.	TRF domain-containing protein.	0.970
ENSACLP00000001223	ENSACLP00000021335	ENSACLP00000001223	ENSACLP00000021335	Uncharacterized protein.	Protection of telomeres 1 homolog.	0.991
ENSACLP00000001223	ENSACLP00000023026	ENSACLP00000001223	ENSACLP00000023026	Uncharacterized protein.	Dyskeratosis congenita 1, dyskerin.	0.692
ENSACLP00000001223	LOC113024563	ENSACLP00000001223	ENSACLP00000018168	Uncharacterized protein.	HTH myb-type domain-containing protein.	0.970
ENSACLP00000001223	ten1	ENSACLP00000001223	ENSACLP00000004809	Uncharacterized protein.	TEN1 subunit of CST complex.	0.771
ENSACLP00000001223	wrap53	ENSACLP00000001223	ENSACLP00000027950	Uncharacterized protein.	WD repeat containing, antisense to TP53.	0.664
ENSACLP00000004087	ENSACLP00000004131	ENSACLP00000004087	ENSACLP00000004131	Uncharacterized protein.	TAN domain-containing protein.	0.690
ENSACLP00000004087	ENSACLP00000004294	ENSACLP00000004087	ENSACLP00000004294	Uncharacterized protein.	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.	0.407
ENSACLP00000004087	ENSACLP00000008384	ENSACLP00000004087	ENSACLP00000008384	Uncharacterized protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.993
ENSACLP00000004087	ENSACLP00000030513	ENSACLP00000004087	ENSACLP00000030513	Uncharacterized protein.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.938
ENSACLP00000004087	LOC113035495	ENSACLP00000004087	ENSACLP00000028068	Uncharacterized protein.	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.407
ENSACLP00000004087	rfc2	ENSACLP00000004087	ENSACLP00000015610	Uncharacterized protein.	Replication factor C (activator 1) 2.	0.845
ENSACLP00000004087	rfc3	ENSACLP00000004087	ENSACLP00000005448	Uncharacterized protein.	Replication factor C (activator 1) 3.	0.835
ENSACLP00000004087	rfc4	ENSACLP00000004087	ENSACLP00000001974	Uncharacterized protein.	Replication factor C (activator 1) 4.	0.845
ENSACLP00000004087	rfc5	ENSACLP00000004087	ENSACLP00000034324	Uncharacterized protein.	Replication factor C (activator 1) 5.	0.834
ENSACLP00000004087	xrcc5	ENSACLP00000004087	ENSACLP00000024019	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 5.	0.930
ENSACLP00000004131	ENSACLP00000004087	ENSACLP00000004131	ENSACLP00000004087	TAN domain-containing protein.	Uncharacterized protein.	0.690
ENSACLP00000004131	ENSACLP00000004294	ENSACLP00000004131	ENSACLP00000004294	TAN domain-containing protein.	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.	0.407
ENSACLP00000004131	ENSACLP00000008384	ENSACLP00000004131	ENSACLP00000008384	TAN domain-containing protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.994